| UniProt ID | EIF3A_MOUSE | |
|---|---|---|
| UniProt AC | P23116 | |
| Protein Name | Eukaryotic translation initiation factor 3 subunit A {ECO:0000255|HAMAP-Rule:MF_03000} | |
| Gene Name | Eif3a | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1344 | |
| Subcellular Localization | Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Nucleus . Centrosomin-A is found in the centrosome. Centrosomin-B is found in the nucleus. | |
| Protein Description | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.. | |
| Protein Sequence | MPAYFQRPENALKRANEFLEVGKKQPALDVLYDVMKSKKHRTWQKIHEPIMLKYLELCVDLRKSHLAKEGLYQYKNICQQVNIKSLEDVVRAYLKLAEEKTEAAKEESQQMVLDIEDLDNIQTPESVLLSAVSGEDTQDRTDRLLLTPWVKFLWESYRQCLDLLRNNSRVERLYHDIAQQAFKFCLQYTRKAEFRKLCDNLRMHLSQIQRHHNQSTAINLNNPESQSMHLETRLVQLDSAISMELWQEAFKAVEDIHGLFSLSKKPPKPQLMANYYNKVSTVFWKSGNALFHASTLHRLYHLSREMRKNLTQEEMQRMSTRVLLATLSIPITPERTDIARLLDMDGIIVEKQRRLATLLGLQAPPTRIGLINDMVRFSVLQYVVPEVKDLYNWLEVEFNPLKLCERVTKVLNWVREQPEKEPELQQYVPQLQNNTILRLLQQVAQIYQSIEFSRLTSLVPFVDAFQLERAIVDAARHCDLQVRIDHTSRTLSFGSDLNYATREDAPVGPHLQSMPSEQIRNQLTAMSSVLAKALEVIRPAHILQEKEEQHQLAVNAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRVKDMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHSRLEDRKRQRKEERKITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELREYQERVKKLEEVERKKRQRELEIEERERRREEERRLGDDPLSRKDSRWGDRDSEGTWRKGPEADSEWRRGPPEKEWRRETRDDERPHRRDEDRLRRLGGDDEERESSLRPDDDRIPRRGLDDDRGPRRGPDEDRFSRRGTDDDRPSWRNADDDRPPRRIGDDDRGSWRHTDDDRPPRRGLDDERGSWRTADEDRGPRRGMDDDRGPRRGGADDERSSWRNADDDRGPRRGMDDDRGPRRGLDDDRGPWRNAAEDRISRRGADDDRGPWRNMDDDRVPRRGDDARPGPWRPFVKPGGWREKEKAREESWGPPRESRPSEEREWDRDKEKDRDNQDREENDKDLERDRDRERDGDREDRFRRPRDEGGWRRGPAEESSSWRDSSRRDDRDREDRRRDRDDRRDLRDLRDRRDLRDDRDRRGPPLRSEREEASSWRRTDDRKDDRTEERDPPRRVPPPALSRDREREREREGEKEKASWRAEKDRESLRRTKNETDEDGWTTVRR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MPAYFQRPENA ----CCCCCCCHHHH | 15.80 | 25367039 | |
| 13 | Acetylation | QRPENALKRANEFLE CCHHHHHHHHHHHHH | 47.24 | 7623861 | |
| 23 | Ubiquitination | NEFLEVGKKQPALDV HHHHHHCCCCCHHHH | 54.10 | 22790023 | |
| 24 | Ubiquitination | EFLEVGKKQPALDVL HHHHHCCCCCHHHHH | 56.43 | 22790023 | |
| 32 | Phosphorylation | QPALDVLYDVMKSKK CCHHHHHHHHHHHCC | 13.31 | 22817900 | |
| 45 | Ubiquitination | KKHRTWQKIHEPIML CCCCCHHHCCHHHHH | 37.28 | 22790023 | |
| 68 | Acetylation | LRKSHLAKEGLYQYK HHHHHHHHHHHHHHH | 59.69 | 22826441 | |
| 68 | Ubiquitination | LRKSHLAKEGLYQYK HHHHHHHHHHHHHHH | 59.69 | - | |
| 68 | Malonylation | LRKSHLAKEGLYQYK HHHHHHHHHHHHHHH | 59.69 | 26320211 | |
| 72 | Phosphorylation | HLAKEGLYQYKNICQ HHHHHHHHHHHHHHH | 22.21 | 22345495 | |
| 74 | Phosphorylation | AKEGLYQYKNICQQV HHHHHHHHHHHHHHC | 7.76 | 25367039 | |
| 75 | Ubiquitination | KEGLYQYKNICQQVN HHHHHHHHHHHHHCC | 25.06 | 22790023 | |
| 133 | Phosphorylation | SVLLSAVSGEDTQDR HHHHHHHCCCCCCCC | 35.86 | 25338131 | |
| 183 | Acetylation | DIAQQAFKFCLQYTR HHHHHHHHHHHHHHH | 37.88 | 30985897 | |
| 196 | Malonylation | TRKAEFRKLCDNLRM HHHHHHHHHHHHHHH | 59.81 | 26320211 | |
| 275 | Phosphorylation | KPQLMANYYNKVSTV CCCCCHHHHHHCEEE | 10.01 | - | |
| 276 | Phosphorylation | PQLMANYYNKVSTVF CCCCHHHHHHCEEEE | 14.33 | - | |
| 300 | Phosphorylation | ASTLHRLYHLSREMR HHHHHHHHHHCHHHH | 10.73 | - | |
| 303 | Phosphorylation | LHRLYHLSREMRKNL HHHHHHHCHHHHHCC | 16.94 | - | |
| 308 | Malonylation | HLSREMRKNLTQEEM HHCHHHHHCCCHHHH | 55.81 | 26320211 | |
| 308 | Ubiquitination | HLSREMRKNLTQEEM HHCHHHHHCCCHHHH | 55.81 | - | |
| 319 | Phosphorylation | QEEMQRMSTRVLLAT HHHHHHHHHHHHHHH | 18.43 | 24719451 | |
| 320 | Phosphorylation | EEMQRMSTRVLLATL HHHHHHHHHHHHHHH | 18.56 | 25777480 | |
| 326 | Phosphorylation | STRVLLATLSIPITP HHHHHHHHHCCCCCC | 22.47 | 24719451 | |
| 328 | Phosphorylation | RVLLATLSIPITPER HHHHHHHCCCCCCCC | 23.20 | 24719451 | |
| 332 | Phosphorylation | ATLSIPITPERTDIA HHHCCCCCCCCCCHH | 17.47 | 18779572 | |
| 336 | Phosphorylation | IPITPERTDIARLLD CCCCCCCCCHHHHHC | 30.05 | 18779572 | |
| 351 | Ubiquitination | MDGIIVEKQRRLATL CCCCHHHHHHHHHHH | 37.91 | 22790023 | |
| 382 | Phosphorylation | VRFSVLQYVVPEVKD HHHHHHHHHCHHHHH | 10.15 | 22817900 | |
| 402 | Ubiquitination | EVEFNPLKLCERVTK CCCCCHHHHHHHHHH | 52.96 | - | |
| 409 | Ubiquitination | KLCERVTKVLNWVRE HHHHHHHHHHHHHHH | 41.70 | 22790023 | |
| 409 | Acetylation | KLCERVTKVLNWVRE HHHHHHHHHHHHHHH | 41.70 | 22826441 | |
| 420 | Ubiquitination | WVREQPEKEPELQQY HHHHCCCCCHHHHHH | 82.39 | 22790023 | |
| 478 | S-nitrosylation | IVDAARHCDLQVRID HHHHHHHCCEEEEEE | 4.68 | 20925432 | |
| 478 | S-nitrosocysteine | IVDAARHCDLQVRID HHHHHHHCCEEEEEE | 4.68 | - | |
| 490 | Phosphorylation | RIDHTSRTLSFGSDL EEECCCCCEECCCCC | 26.90 | 25777480 | |
| 492 | Phosphorylation | DHTSRTLSFGSDLNY ECCCCCEECCCCCCC | 27.27 | 28507225 | |
| 495 | Phosphorylation | SRTLSFGSDLNYATR CCCEECCCCCCCCCC | 36.59 | 25777480 | |
| 499 | Phosphorylation | SFGSDLNYATREDAP ECCCCCCCCCCCCCC | 19.35 | 25777480 | |
| 501 | Phosphorylation | GSDLNYATREDAPVG CCCCCCCCCCCCCCC | 25.00 | 25777480 | |
| 524 | Phosphorylation | EQIRNQLTAMSSVLA HHHHHHHHHHHHHHH | 15.56 | 28059163 | |
| 528 | Phosphorylation | NQLTAMSSVLAKALE HHHHHHHHHHHHHHH | 14.20 | 29514104 | |
| 532 | Ubiquitination | AMSSVLAKALEVIRP HHHHHHHHHHHHHCH | 49.71 | - | |
| 559 | Acetylation | LAVNAYLKNSRKEHQ HHHHHHHHHCHHHHH | 39.95 | 23236377 | |
| 559 | Malonylation | LAVNAYLKNSRKEHQ HHHHHHHHHCHHHHH | 39.95 | 26320211 | |
| 559 | Ubiquitination | LAVNAYLKNSRKEHQ HHHHHHHHHCHHHHH | 39.95 | - | |
| 574 | Phosphorylation | RILARRQTIEERKER HHHHHHHHHHHHHHH | 28.66 | 22324799 | |
| 579 | Ubiquitination | RQTIEERKERLESLN HHHHHHHHHHHHHCC | 50.93 | 22790023 | |
| 584 | Phosphorylation | ERKERLESLNIQREK HHHHHHHHCCHHHHH | 31.16 | 25521595 | |
| 591 | Ubiquitination | SLNIQREKEELEQRE HCCHHHHHHHHHHHH | 59.69 | 22790023 | |
| 603 | Malonylation | QREAELQKVRKAEEE HHHHHHHHHHHHHHH | 57.54 | 26320211 | |
| 603 | Ubiquitination | QREAELQKVRKAEEE HHHHHHHHHHHHHHH | 57.54 | - | |
| 632 | Malonylation | LQEHEQIKKKTVRER HHHHHHHHHHHHHHH | 48.16 | 26320211 | |
| 651 | Ubiquitination | KKTELGAKAFKDIDI HHCHHHHHHCCCCCH | 53.19 | 22790023 | |
| 654 | Ubiquitination | ELGAKAFKDIDIEDL HHHHHHCCCCCHHHH | 59.64 | - | |
| 672 | Ubiquitination | DPDFIMAKQVEQLEK CHHHHHHHHHHHHHH | 37.18 | - | |
| 694 | Ubiquitination | RLKNQEKKIDYFERA HHHHHHHHHHHHHHH | 39.80 | - | |
| 694 | Malonylation | RLKNQEKKIDYFERA HHHHHHHHHHHHHHH | 39.80 | 26320211 | |
| 711 | Ubiquitination | LEEIPLIKSAYEEQR HHHCCCCHHHHHHHC | 36.39 | 22790023 | |
| 770 | Phosphorylation | RLKAARQSVYEEKLK HHHHHHHHHHHHHHH | 22.55 | 25367039 | |
| 772 | Phosphorylation | KAARQSVYEEKLKQF HHHHHHHHHHHHHHH | 24.50 | 25367039 | |
| 775 | Acetylation | RQSVYEEKLKQFEER HHHHHHHHHHHHHHH | 49.39 | 23954790 | |
| 775 | Ubiquitination | RQSVYEEKLKQFEER HHHHHHHHHHHHHHH | 49.39 | 22790023 | |
| 777 | Ubiquitination | SVYEEKLKQFEERLA HHHHHHHHHHHHHHH | 65.10 | - | |
| 824 | Ubiquitination | RAEEQMLKEREERER HHHHHHHHHHHHHHH | 49.75 | 22790023 | |
| 888 | Phosphorylation | DPLSRKDSRWGDRDS CCCCCCCCCCCCCCC | 32.73 | 29514104 | |
| 895 | Phosphorylation | SRWGDRDSEGTWRKG CCCCCCCCCCCCCCC | 38.53 | 26525534 | |
| 948 | Phosphorylation | GDDEERESSLRPDDD CCHHHHHHHCCCCCC | 40.68 | 28066266 | |
| 949 | Phosphorylation | DDEERESSLRPDDDR CHHHHHHHCCCCCCC | 24.52 | 24719451 | |
| 978 | Phosphorylation | GPDEDRFSRRGTDDD CCCCCCCCCCCCCCC | 23.20 | 25266776 | |
| 982 | Phosphorylation | DRFSRRGTDDDRPSW CCCCCCCCCCCCCCC | 34.15 | 23684622 | |
| 988 | Phosphorylation | GTDDDRPSWRNADDD CCCCCCCCCCCCCCC | 39.29 | 25521595 | |
| 1008 | Phosphorylation | IGDDDRGSWRHTDDD CCCCCCCCCCCCCCC | 23.10 | 23684622 | |
| 1028 | Phosphorylation | GLDDERGSWRTADED CCCCCCCCCCCCCCC | 21.43 | 28066266 | |
| 1059 | Phosphorylation | GADDERSSWRNADDD CCCCCCHHCCCCCCC | 35.95 | 18779572 | |
| 1099 | Phosphorylation | NAAEDRISRRGADDD HHHHHHHHHCCCCCC | 19.47 | 26824392 | |
| 1149 | Phosphorylation | KEKAREESWGPPRES HHHHHHHHCCCCCCC | 32.36 | 26824392 | |
| 1156 | Phosphorylation | SWGPPRESRPSEERE HCCCCCCCCCHHHHC | 51.26 | 28066266 | |
| 1159 | Phosphorylation | PPRESRPSEEREWDR CCCCCCCHHHHCCHH | 51.48 | 28066266 | |
| 1217 | Phosphorylation | RRGPAEESSSWRDSS CCCCCCCCCCCCCCC | 22.60 | 26060331 | |
| 1218 | Phosphorylation | RGPAEESSSWRDSSR CCCCCCCCCCCCCCC | 36.88 | 26060331 | |
| 1219 | Phosphorylation | GPAEESSSWRDSSRR CCCCCCCCCCCCCCC | 35.10 | 26060331 | |
| 1223 | Phosphorylation | ESSSWRDSSRRDDRD CCCCCCCCCCCCCCC | 19.71 | 29899451 | |
| 1224 | Phosphorylation | SSSWRDSSRRDDRDR CCCCCCCCCCCCCCH | 35.31 | 29514104 | |
| 1277 | Phosphorylation | EASSWRRTDDRKDDR HHHHHCCCCCCCCCC | 33.41 | 29899451 | |
| 1285 | Phosphorylation | DDRKDDRTEERDPPR CCCCCCCCCCCCCCC | 49.55 | 25521595 | |
| 1300 | Phosphorylation | RVPPPALSRDRERER CCCCCCCCCHHHHHH | 33.95 | 26824392 | |
| 1326 | Phosphorylation | RAEKDRESLRRTKNE HHHHHHHHHHHHCCC | 28.24 | 25266776 | |
| 1334 | Phosphorylation | LRRTKNETDEDGWTT HHHHCCCCCCCCCCC | 54.83 | 26525534 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EIF3A_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EIF3A_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EIF3A_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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