CI114_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CI114_HUMAN
• UniProt AC: Q5T280
• Protein Name: Putative methyltransferase C9orf114 {ECO:0000305}
• Gene Name: SPOUT1 {ECO:0000312|HGNC:HGNC:26933}
• Organism: Homo sapiens (Human).
• Sequence Length: 376
• Subcellular Localization: Cytoplasm, cytoskeleton, spindle . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Associated with the outer kinetochore.
• Protein Description: Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. [PubMed: 20813266]
• Protein Sequence: MAERGRKRPCGPGEHGQRIEWRKWKQQKKEEKKKWKDLKLMKKLERQRAQEEQAKRLEEEEAAAEKEDRGRPYTLSVALPGSILDNAQSPELRTYLAGQIARACAIFCVDEIVVFDEEGQDAKTVEGEFTGVGKKGQACVQLARILQYLECPQYLRKAFFPKHQDLQFAGLLNPLDSPHHMRQDEESEFREGIVVDRPTRPGHGSFVNCGMKKEVKIDKNLEPGLRVTVRLNQQQHPDCKTYHGKVVSSQDPRTKAGLYWGYTVRLASCLSAVFAEAPFQDGYDLTIGTSERGSDVASAQLPNFRHALVVFGGLQGLEAGADADPNLEVAEPSVLFDLYVNTCPGQGSRTIRTEEAILISLAALQPGLIQAGARHT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Acetylation	KKKWKDLKLMKKLER HHHHHHHHHHHHHHH	57.58	30587365
66	Ubiquitination	EEEAAAEKEDRGRPY HHHHHHHHHHCCCCE	61.25	21906983
66	Acetylation	EEEAAAEKEDRGRPY HHHHHHHHHHCCCCE	61.25	26051181
82	Phosphorylation	LSVALPGSILDNAQS EEEECCCHHHHCCCC	20.31	17081983
123	Sumoylation	DEEGQDAKTVEGEFT CCCCCCCEEEEEEEE	62.48	-
134	Ubiquitination	GEFTGVGKKGQACVQ EEEECCCCHHHHHHH	51.85	29967540
134	Acetylation	GEFTGVGKKGQACVQ EEEECCCCHHHHHHH	51.85	25953088
135	Ubiquitination	EFTGVGKKGQACVQL EEECCCCHHHHHHHH	50.77	29967540
148	Ubiquitination	QLARILQYLECPQYL HHHHHHHHHHCHHHH	10.87	21963094
162	Ubiquitination	LRKAFFPKHQDLQFA HHHHHCCCCCCCCCC	49.06	29967540
177	Phosphorylation	GLLNPLDSPHHMRQD CCCCCCCCCCCCCCC	33.54	28555341
219	Ubiquitination	KKEVKIDKNLEPGLR CCEEECCCCCCCCCE	67.89	29967540
240	Ubiquitination	QQQHPDCKTYHGKVV CCCCCCCCEECEEEC	60.54	-
241	Phosphorylation	QQHPDCKTYHGKVVS CCCCCCCEECEEECC	27.38	-
242	Phosphorylation	QHPDCKTYHGKVVSS CCCCCCEECEEECCC	8.28	-
245	Ubiquitination	DCKTYHGKVVSSQDP CCCEECEEECCCCCC	26.59	29967540
294	Phosphorylation	IGTSERGSDVASAQL EECCCCCCCCHHHCC	34.82	20068231
298	Phosphorylation	ERGSDVASAQLPNFR CCCCCCHHHCCCCCC	19.18	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CI114_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CI114_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CI114_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NAF1_HUMAN	NAF1	physical	26472758
DKC1_HUMAN	DKC1	physical	26472758

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.