EIF2A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EIF2A_MOUSE
• UniProt AC: Q8BJW6
• Protein Name: Eukaryotic translation initiation factor 2A
• Gene Name: Eif2a
• Organism: Mus musculus (Mouse).
• Sequence Length: 581
• Protein Description: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner..
• Protein Sequence: MAPSTPLLTVRGSEGLYMVNGPPHFTESTVLPRESGRNCKVYTFSKDGTLFAWSNGEKVNIINVANKGLLHSFDLPKAVCLEFSPNNTVLATWQPYTTSKDGTAGTPNLQLYDMKTGACLKSFIQKKMQNWCPSWSDDEIICARNVNNEVHFFENNNFNTIANKLHLQKVNDFNLSPGTQPYKVAVYVPGSKGAPSFVRLYQYPNFAGPQAALANKSFFKADKVTMLWNKKATAVLVIASTEVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKATVFNLKCDPVFDFGTGPRNAAFYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSLLHKYDVPSNGELWQVSWQPFLDGIFPAKTIKYQAVPSEVPSEEPKVATAYRPPALRNKPVTNSKLHEEEPPQNMKPHPGSDKPLSKTALKNQRKHEAKKAAKQEARSDAAPTPVPQSAPRNTVTQSASGDPEVDKKIKNLKKKLKAIEQLKEQAAAGKQLEKNQLEKIQKETALLQELEDLELGV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MAPSTPLL -------CCCCCCEE	12.81	-
2	Acetylation	------MAPSTPLLT ------CCCCCCEEE	13.52	-
4	Phosphorylation	----MAPSTPLLTVR ----CCCCCCEEEEE	32.87	26643407
5	Phosphorylation	---MAPSTPLLTVRG ---CCCCCCEEEEEC	19.52	29514104
9	Phosphorylation	APSTPLLTVRGSEGL CCCCCEEEEECCCCE	18.81	19854140
40	Malonylation	RESGRNCKVYTFSKD CCCCCCCEEEEECCC	41.65	26320211
40	Ubiquitination	RESGRNCKVYTFSKD CCCCCCCEEEEECCC	41.65	-
103	Phosphorylation	YTTSKDGTAGTPNLQ EEECCCCCCCCCCEE	31.86	26643407
106	Phosphorylation	SKDGTAGTPNLQLYD CCCCCCCCCCEEEEE	13.41	25521595
136	Phosphorylation	QNWCPSWSDDEIICA HHCCCCCCCCCEEEE	39.25	26525534
169	Ubiquitination	ANKLHLQKVNDFNLS HHHHHCEECCCCCCC	49.74	-
169	Malonylation	ANKLHLQKVNDFNLS HHHHHCEECCCCCCC	49.74	26320211
176	Phosphorylation	KVNDFNLSPGTQPYK ECCCCCCCCCCCCEE	23.53	26643407
179	Phosphorylation	DFNLSPGTQPYKVAV CCCCCCCCCCEEEEE	29.74	26643407
182	Phosphorylation	LSPGTQPYKVAVYVP CCCCCCCEEEEEECC	14.31	26643407
187	Phosphorylation	QPYKVAVYVPGSKGA CCEEEEEECCCCCCC	7.38	26643407
191	Phosphorylation	VAVYVPGSKGAPSFV EEEECCCCCCCCCEE	23.11	26643407
192	Ubiquitination	AVYVPGSKGAPSFVR EEECCCCCCCCCEEE	66.07	-
192	Malonylation	AVYVPGSKGAPSFVR EEECCCCCCCCCEEE	66.07	26320211
196	Phosphorylation	PGSKGAPSFVRLYQY CCCCCCCCEEEEECC	35.52	26643407
201	Phosphorylation	APSFVRLYQYPNFAG CCCEEEEECCCCCCC	8.74	29899451
203	Phosphorylation	SFVRLYQYPNFAGPQ CEEEEECCCCCCCHH	6.13	29899451
250	Phosphorylation	VDKTGASYYGEQTLH CCCCCCCCCCEEEEE	18.24	22817900
347	Acetylation	QMEVWDVKNYKLISK EEEEEECCCCEEECC	52.68	23954790
362	Phosphorylation	PVASDSTYFAWCPDG CCCCCCCEEEECCCC	8.68	22817900
377	S-nitrosocysteine	EHILTATCAPRLRVN CEEEEEEECCEEEEC	4.56	-
377	S-nitrosylation	EHILTATCAPRLRVN CEEEEEEECCEEEEC	4.56	20925432
427	Ubiquitination	IFPAKTIKYQAVPSE CCCCCEEEEEECCCC	36.22	-
427	Malonylation	IFPAKTIKYQAVPSE CCCCCEEEEEECCCC	36.22	26320211
428	Phosphorylation	FPAKTIKYQAVPSEV CCCCEEEEEECCCCC	9.61	29514104
446	Phosphorylation	EPKVATAYRPPALRN CCCCEECCCCHHHHC	21.21	29514104
503	Phosphorylation	AAKQEARSDAAPTPV HHHHHHHHCCCCCCC	38.35	25619855
508	Phosphorylation	ARSDAAPTPVPQSAP HHHCCCCCCCCCCCC	31.99	25521595
513	Phosphorylation	APTPVPQSAPRNTVT CCCCCCCCCCCCCCC	33.88	28066266
520	Phosphorylation	SAPRNTVTQSASGDP CCCCCCCCCCCCCCH	18.11	30635358
522	Phosphorylation	PRNTVTQSASGDPEV CCCCCCCCCCCCHHH	18.29	25266776
524	Phosphorylation	NTVTQSASGDPEVDK CCCCCCCCCCHHHHH	49.31	27841257
563	Malonylation	LEKNQLEKIQKETAL HHHHHHHHHHHHHHH	60.06	26320211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EIF2A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EIF2A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EIF2A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MAP2_MOUSE	Metap2	physical	15544353

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.