WBP11_MOUSE - dbPTM
WBP11_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WBP11_MOUSE
UniProt AC Q923D5
Protein Name WW domain-binding protein 11
Gene Name Wbp11
Organism Mus musculus (Mouse).
Sequence Length 641
Subcellular Localization Nucleus. Cytoplasm. Predominantly located in the nucleus with granular heterogeneous distribution. Excluded from nucleoli in interphase cells, distributed throughout cytoplasm in dividing cells. Colocalized with SC35 and U2B in the nucleus. In the cy
Protein Description Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity..
Protein Sequence MGRRSTSSTKSGKFMNPTDQARKEARKRELKKNKKQRMMVRAAVLKMKDPKQIIRDMEKLDEMEFNPVQQPQLNEKVLKDKRKKLRETFERILRLYEKENPDIYKELRKLEVEYEQKRAQLSQYFDAVKNAQHVEVESIPLPDMPHAPSNILIQDIPLPGAQPPSILKKTSAYGPPARAVSILPLLGHGVPRLPPGRKPPGPPPGPPPPQVLQMYGRKVGFALDLPPRRRDEDMLYSPELAQRGHDDDMSSTSEDDGYPEDMDQDKHDDSTEDSDTDRSDAESDGDEFGHREDSERDNTEEKKSGLSVRFADMPGKSRKKKKNMKELTPLQAMMLRMAGQEIPEEGREVEEFSEEEDADDSDDSEAEKQSQKQHKDDGHSDSTAAASSQQQAPPQSAPASQIQAPPMPGPPPLGPPPAPPLRPPGPPTGLPPGPPPGAPPFLRPPGMPGIRGPLPRLLPPGPPPGRPPGPPPGPPPGLPPGPPPRGPPPRLPPPAPPGIPPPRPGMMRPPLVPPLGPAPPGLFPPAPLPNPGVLSAPPSLIQRPKADDASAATIEKKATATISAKPQITNPKAEVTRFVPTALRVRRENKGATAVPQRRSEDDSAVPVAKAAPRSGPSVAVSVQTKDDVYEAFMKEMEGLL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13AcetylationTSSTKSGKFMNPTDQ
CCCCCCCCCCCHHHH		48.8323806337
171PhosphorylationPSILKKTSAYGPPAR
CHHHHHCCCCCCCCH		28.5122817900
181PhosphorylationGPPARAVSILPLLGH
CCCCHHHHHHHHCCC		19.8826824392
192MethylationLLGHGVPRLPPGRKP
HCCCCCCCCCCCCCC		58.37-
236PhosphorylationRRDEDMLYSPELAQR
CCCCCCCCCHHHHHC		18.6227742792
237PhosphorylationRDEDMLYSPELAQRG
CCCCCCCCHHHHHCC		14.1326824392
250PhosphorylationRGHDDDMSSTSEDDG
CCCCCCCCCCCCCCC		37.1429550500
251PhosphorylationGHDDDMSSTSEDDGY
CCCCCCCCCCCCCCC		29.3425521595
252PhosphorylationHDDDMSSTSEDDGYP
CCCCCCCCCCCCCCC		28.9125521595
253PhosphorylationDDDMSSTSEDDGYPE
CCCCCCCCCCCCCCC		40.7625195567
279PhosphorylationEDSDTDRSDAESDGD
CCCCCCHHHHHCCCC		43.94-
283PhosphorylationTDRSDAESDGDEFGH
CCHHHHHCCCCCCCC		48.9225195567
294PhosphorylationEFGHREDSERDNTEE
CCCCCCCCCCCCHHH		29.7628066266
299PhosphorylationEDSERDNTEEKKSGL
CCCCCCCHHHHHHCC		50.2228066266
316AcetylationRFADMPGKSRKKKKN
ECCCCCCCCCCCCCC		41.0123806337
325AcetylationRKKKKNMKELTPLQA
CCCCCCHHHCHHHHH		59.9922826441
328PhosphorylationKKNMKELTPLQAMML
CCCHHHCHHHHHHHH		24.0426745281
353PhosphorylationGREVEEFSEEEDADD
CCCHHHCCCCCCCCC		47.5925521595
361PhosphorylationEEEDADDSDDSEAEK
CCCCCCCCCCHHHHH		43.8125521595
364PhosphorylationDADDSDDSEAEKQSQ
CCCCCCCHHHHHHHH		43.6325521595
370PhosphorylationDSEAEKQSQKQHKDD
CHHHHHHHHHHHCCC		50.8722817900
565AcetylationATATISAKPQITNPK
HHCEEECCCCCCCCC		30.5723806337
593PhosphorylationRRENKGATAVPQRRS
HHHCCCCCCCCCCCC		36.5426026062
600PhosphorylationTAVPQRRSEDDSAVP
CCCCCCCCCCCCCCC		47.7926824392
604PhosphorylationQRRSEDDSAVPVAKA
CCCCCCCCCCCHHHC		43.4125266776
630PhosphorylationVQTKDDVYEAFMKEM
EECCHHHHHHHHHHH		14.4525159016
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of WBP11_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WBP11_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WBP11_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PP1A_MOUSEPpp1caphysical
14640981
VATB2_HUMANATP6V1B2physical
26496610
P4HA1_HUMANP4HA1physical
26496610
PDIA1_HUMANP4HBphysical
26496610
P4HA2_HUMANP4HA2physical
26496610
LRRF2_HUMANLRRFIP2physical
26496610
PQBP1_HUMANPQBP1physical
26496610
PRP8_HUMANPRPF8physical
26496610
PRP6_HUMANPRPF6physical
26496610
PRP31_HUMANPRPF31physical
26496610
LTV1_HUMANLTV1physical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WBP11_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-353, AND MASSSPECTROMETRY.
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237, AND MASSSPECTROMETRY.
"Identification of phosphoproteins and their phosphorylation sites inthe WEHI-231 B lymphoma cell line.";
Shu H., Chen S., Bi Q., Mumby M., Brekken D.L.;
Mol. Cell. Proteomics 3:279-286(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237, AND MASSSPECTROMETRY.

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