dbPTM

SYGP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SYGP1_MOUSE
UniProt AC	F6SEU4
Protein Name	Ras/Rap GTPase-activating protein SynGAP
Gene Name	Syngap1
Organism	Mus musculus (Mouse).
Sequence Length	1340
Subcellular Localization	Membrane Peripheral membrane protein. Cell junction, synapse. Mostly in excitatory glutamatergic synapses (By similarity). receptor activation or SYNGAP1/MPDZ complex disruption. Phosphorylation by PLK2 promotes its activity (By similarity)..
Protein Description	Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity)..
Protein Sequence	MSRSRASIHRGSIPAMSYAPFRDVRGPPMHRTQYVHSPYDRPGWNPRFCIISGNQLLMLDEDEIHPLLIRDRRSESSRNKLLRRTVSVPVEGRPHGEHEYHLGRSRRKSVPGGKQYSMEAAPAAPFRPSQGFLSRRLKSSIKRTKSQPKLDRTSSFRQILPRFRSADHDRARLMQSFKESHSHESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEFCFEVTTSSGTKCFACRSAAERDKWIENLQRAVKPNKDNSRRVDNVLKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSASGDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRMLCAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTASSLAEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAERGREDIADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSMQQFLYEISNLDTLTNSSSFEGYIDLGRELSTLHALLWEVLPQLSKEALLKLGPLPRLLNDISTALRNPNIQRQPSRQSERTRSQPMVLRGPSAEMQGYMMRDLNSSIDLQSFMARGLNSSMDMARLPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKMLSVNKSVSMLDLQGDGPGGRLNSSSVSNLAAVGDLLHSSQASLTAALGLRPAPAGRLSQGSGSSITAAGMRLSQMGVTTDGVPAQQLRIPLSFQNPLFHMAADGPGPPAGHGGSSGHGPPSSHHHHHHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEFGPSGTDFTRRQLSLQDSLQHMLSPPQITIGPQRPAPSGPGGGSGGGSGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPARPRQQSLSKEGSIGGSGGSGGGGGGGLKPSITKQHSQTPSTLNPTMPASERTVAWVSNMPHLSADIESAHIEREEYKLKEYSKSMDESRLDRVKEYEEEIHSLKERLHMSNRKLEEYERRLLSQEEQTSKILMQYQARLEQSEKRLRQQQVEKDSQIKSIIGRLMLVEEELRRDHPAMAEPLPEPKKRLLDAQERQLPPLGPTNPRVTLAPPWNGLAPPAPPPPPRLQITENGEFRNTADH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MSRSRASIHRG ----CCCCCHHHCCC	41.30	29899451
7	Phosphorylation	-MSRSRASIHRGSIP -CCCCCHHHCCCCCC	20.16	29899451
12	Phosphorylation	RASIHRGSIPAMSYA CHHHCCCCCCCHHCC	25.92	19060867
17	Phosphorylation	RGSIPAMSYAPFRDV CCCCCCHHCCCCCCC	21.90	29899451
18	Phosphorylation	GSIPAMSYAPFRDVR CCCCCHHCCCCCCCC	12.76	-
28	Ubiquitination	FRDVRGPPMHRTQYV CCCCCCCCCCCCCCC	33.75	27667366
34	Phosphorylation	PPMHRTQYVHSPYDR CCCCCCCCCCCCCCC	10.26	29899451
37	Phosphorylation	HRTQYVHSPYDRPGW CCCCCCCCCCCCCCC	18.34	29899451
38	Ubiquitination	RTQYVHSPYDRPGWN CCCCCCCCCCCCCCC	21.84	27667366
39	Phosphorylation	TQYVHSPYDRPGWNP CCCCCCCCCCCCCCC	27.83	29899451
55	Ubiquitination	FCIISGNQLLMLDED EEEEECCEEEEECHH	39.23	27667366
85	Phosphorylation	RNKLLRRTVSVPVEG HHHHHHEEEECCCCC	15.65	29899451
86	Ubiquitination	NKLLRRTVSVPVEGR HHHHHEEEECCCCCC	5.28	27667366
87	Phosphorylation	KLLRRTVSVPVEGRP HHHHEEEECCCCCCC	21.79	22324799
93	Methylation	VSVPVEGRPHGEHEY EECCCCCCCCCCCCE	13.41	16189349
100	Phosphorylation	RPHGEHEYHLGRSRR CCCCCCCEECCCCCC	12.30	29899451
104	Methylation	EHEYHLGRSRRKSVP CCCEECCCCCCCCCC	33.09	16189355
105	Phosphorylation	HEYHLGRSRRKSVPG CCEECCCCCCCCCCC	34.34	-
108	Ubiquitination	HLGRSRRKSVPGGKQ ECCCCCCCCCCCCCC	55.48	27667366
109	Phosphorylation	LGRSRRKSVPGGKQY CCCCCCCCCCCCCCC	31.56	20415495
114	Ubiquitination	RKSVPGGKQYSMEAA CCCCCCCCCCCCCCC	52.56	27667366
116	Phosphorylation	SVPGGKQYSMEAAPA CCCCCCCCCCCCCCC	17.30	19060867
117	Phosphorylation	VPGGKQYSMEAAPAA CCCCCCCCCCCCCCC	13.98	19060867
129	Phosphorylation	PAAPFRPSQGFLSRR CCCCCCCCCCHHHHH	38.38	29899451
134	Phosphorylation	RPSQGFLSRRLKSSI CCCCCHHHHHHHHHH	17.06	29899451
146	Phosphorylation	SSIKRTKSQPKLDRT HHHHHHCCCCCCCCC	51.61	28382018
153	Phosphorylation	SQPKLDRTSSFRQIL CCCCCCCCHHHHHHH	28.52	29899451
154	Phosphorylation	QPKLDRTSSFRQILP CCCCCCCHHHHHHHH	28.51	29899451
155	Phosphorylation	PKLDRTSSFRQILPR CCCCCCHHHHHHHHH	24.68	29899451
165	Phosphorylation	QILPRFRSADHDRAR HHHHHHHCCCHHHHH	35.02	22324799
176	Phosphorylation	DRARLMQSFKESHSH HHHHHHHHHHHCCCC	25.07	21183079
191	Ubiquitination	ESLLSPSSAAEALEL CCCCCHHHHHHHHHC	34.58	27667366
241	Ubiquitination	RSAAERDKWIENLQR CCHHHHHHHHHHHHH	57.18	-
300	Phosphorylation	RTTSKPRSASGDTVF CCCCCCCCCCCCEEE	35.00	20415495
302	Phosphorylation	TSKPRSASGDTVFWG CCCCCCCCCCEEEEC	38.15	19060867
339	Ubiquitination	DKKRKKDKAGYVGLV CCCCCCCCCCCEEEE	53.22	22790023
342	Phosphorylation	RKKDKAGYVGLVTVP CCCCCCCCEEEEEHH	9.01	20415495
366	Phosphorylation	TEQWYPVTLPTGSGG CCCEEEEEECCCCCC	23.63	20415495
369	Phosphorylation	WYPVTLPTGSGGSGG EEEEEECCCCCCCCC	47.28	21183079
371	Phosphorylation	PVTLPTGSGGSGGMG EEEECCCCCCCCCCC	42.32	20047950
374	Phosphorylation	LPTGSGGSGGMGSGG ECCCCCCCCCCCCCC	35.38	19060867
375	Ubiquitination	PTGSGGSGGMGSGGG CCCCCCCCCCCCCCC	33.12	27667366
379	Phosphorylation	GGSGGMGSGGGGGSG CCCCCCCCCCCCCCC	25.93	19060867
385	Phosphorylation	GSGGGGGSGGGSGGK CCCCCCCCCCCCCCC	37.22	19060867
389	Phosphorylation	GGGSGGGSGGKGKGG CCCCCCCCCCCCCCC	47.88	19060867
406	Ubiquitination	AVRLKARYQTMSILP CCHHHHHHHHHCCCC	17.13	27667366
416	Ubiquitination	MSILPMELYKEFAEY HCCCCHHHHHHHHHH	6.35	27667366
433	Ubiquitination	NHYRMLCAVLEPALN HHHHHHHHHHHHHHC	12.64	27667366
449	Phosphorylation	KGKEEVASALVHILQ CCHHHHHHHHHHHHH	27.58	-
464	Ubiquitination	STGKAKDFLSDMAMS HCCCHHHHHHHHHHH	7.48	27667366
466	Phosphorylation	GKAKDFLSDMAMSEV CCHHHHHHHHHHHHH	25.90	-
467	Ubiquitination	KAKDFLSDMAMSEVD CHHHHHHHHHHHHHH	30.89	27667366
478	Ubiquitination	SEVDRFMEREHLIFR HHHHHHHHHHHHHHH	52.81	27667366
492	Ubiquitination	RENTLATKAIEEYMR HHCHHHHHHHHHHHH	41.58	22790023
507	Ubiquitination	LIGQKYLKDAIGEFI HHCHHHHHHHHHHHH	41.86	22790023
525	Ubiquitination	YESEENCEVDPIKCT HHCCCCCCCCCCCCC	62.63	27667366
534	Phosphorylation	DPIKCTASSLAEHQA CCCCCCHHHHHHHHH	14.02	29899451
535	Phosphorylation	PIKCTASSLAEHQAN CCCCCHHHHHHHHHH	29.18	19060867
571	Phosphorylation	ELKEVFASWRLRCAE HHHHHHHHHHHHHHH	10.98	21183079
574	Ubiquitination	EVFASWRLRCAERGR HHHHHHHHHHHHHCC	4.25	27667366
580	Ubiquitination	RLRCAERGREDIADR HHHHHHHCCHHHHHH	28.91	27667366
593	Ubiquitination	DRLISASLFLRFLCP HHHHHHHHHHHHHHH	4.72	27667366
624	Ubiquitination	EQTSRTLTLIAKVIQ HHHHHHHHHHHHHHH	18.59	27667366
634	Ubiquitination	AKVIQNLANFSKFTS HHHHHHHHCHHHCCC	23.67	27667366
638	Ubiquitination	QNLANFSKFTSKEDF HHHHCHHHCCCHHHH	48.82	22790023
651	Ubiquitination	DFLGFMNEFLELEWG HHHHHHHHHHHCCCH	39.56	27667366
655	Ubiquitination	FMNEFLELEWGSMQQ HHHHHHHCCCHHHHH	7.94	27667366
676	Ubiquitination	NLDTLTNSSSFEGYI CCCHHCCCCCCCCCH	23.32	27667366
682	Ubiquitination	NSSSFEGYIDLGREL CCCCCCCCHHHHHHH	5.53	27667366
707	Ubiquitination	LPQLSKEALLKLGPL HHHCCHHHHHHHCCH	23.18	27667366
710	Ubiquitination	LSKEALLKLGPLPRL CCHHHHHHHCCHHHH	52.85	22790023
717	Ubiquitination	KLGPLPRLLNDISTA HHCCHHHHHHHHHHH	5.04	27667366
722	Phosphorylation	PRLLNDISTALRNPN HHHHHHHHHHHHCCC	15.53	29233185
723	Phosphorylation	RLLNDISTALRNPNI HHHHHHHHHHHCCCC	30.00	20415495
734	Ubiquitination	NPNIQRQPSRQSERT CCCCCCCCCCCCHHH	33.40	27667366
735	Phosphorylation	PNIQRQPSRQSERTR CCCCCCCCCCCHHHC	34.31	29899451
743	Phosphorylation	RQSERTRSQPMVLRG CCCHHHCCCCEEECC	37.71	-
752	Phosphorylation	PMVLRGPSAEMQGYM CEEECCCCHHHCHHH	39.42	25521595
758	Phosphorylation	PSAEMQGYMMRDLNS CCHHHCHHHHCCCCC	3.20	29899451
765	Phosphorylation	YMMRDLNSSIDLQSF HHHCCCCCCCCHHHH	35.65	22324799
765	Ubiquitination	YMMRDLNSSIDLQSF HHHCCCCCCCCHHHH	35.65	27667366
766	Phosphorylation	MMRDLNSSIDLQSFM HHCCCCCCCCHHHHH	21.03	22324799
779	Phosphorylation	FMARGLNSSMDMARL HHHHCCCCCCCHHCC	31.89	22324799
779	Ubiquitination	FMARGLNSSMDMARL HHHHCCCCCCCHHCC	31.89	27667366
780	Phosphorylation	MARGLNSSMDMARLP HHHCCCCCCCHHCCC	20.09	22324799
788	Phosphorylation	MDMARLPSPTKEKPP CCHHCCCCCCCCCCC	50.20	22324799
790	Phosphorylation	MARLPSPTKEKPPPP HHCCCCCCCCCCCCC	57.06	29899451
793	Ubiquitination	LPSPTKEKPPPPPPG CCCCCCCCCCCCCCC	65.46	22790023
807	Phosphorylation	GGGKDLFYVSRPPLA CCCCCCEEECCCCCC	12.57	28059163
810	Dimethylation	KDLFYVSRPPLARSS CCCEEECCCCCCCCC	27.15	-
810	Methylation	KDLFYVSRPPLARSS CCCEEECCCCCCCCC	27.15	54541637
816	Phosphorylation	SRPPLARSSPAYCTS CCCCCCCCCCCCCCC	34.76	25521595
817	Phosphorylation	RPPLARSSPAYCTSS CCCCCCCCCCCCCCC	14.16	25521595
820	Phosphorylation	LARSSPAYCTSSSDI CCCCCCCCCCCCCCC	10.31	25521595
822	Phosphorylation	RSSPAYCTSSSDITE CCCCCCCCCCCCCCC	20.97	25521595
823	Phosphorylation	SSPAYCTSSSDITEP CCCCCCCCCCCCCCH	25.04	25521595
824	Phosphorylation	SPAYCTSSSDITEPE CCCCCCCCCCCCCHH	17.55	25521595
825	Phosphorylation	PAYCTSSSDITEPEQ CCCCCCCCCCCCHHH	32.57	25521595
828	Phosphorylation	CTSSSDITEPEQKML CCCCCCCCCHHHHHH	50.94	25521595
833	Ubiquitination	DITEPEQKMLSVNKS CCCCHHHHHHHCCCC	39.90	-
836	Phosphorylation	EPEQKMLSVNKSVSM CHHHHHHHCCCCEEE	21.83	29899451
839	Ubiquitination	QKMLSVNKSVSMLDL HHHHHCCCCEEEEEC	50.51	22790023
840	Phosphorylation	KMLSVNKSVSMLDLQ HHHHCCCCEEEEECC	17.77	22324799
842	Phosphorylation	LSVNKSVSMLDLQGD HHCCCCEEEEECCCC	22.25	22324799
857	Phosphorylation	GPGGRLNSSSVSNLA CCCCCCCCCHHCHHH	28.69	-
858	Phosphorylation	PGGRLNSSSVSNLAA CCCCCCCCHHCHHHH	33.41	29899451
861	Phosphorylation	RLNSSSVSNLAAVGD CCCCCHHCHHHHHHH	28.24	29899451
872	Phosphorylation	AVGDLLHSSQASLTA HHHHHHHHCHHHHHH	24.90	19060867
873	Phosphorylation	VGDLLHSSQASLTAA HHHHHHHCHHHHHHH	21.01	19060867
876	Phosphorylation	LLHSSQASLTAALGL HHHHCHHHHHHHHCC	20.72	19060867
878	Phosphorylation	HSSQASLTAALGLRP HHCHHHHHHHHCCCC	13.85	29899451
892	O-linked_Glycosylation	PAPAGRLSQGSGSSI CCCCCCCCCCCCCCC	31.00	6729327
892	Phosphorylation	PAPAGRLSQGSGSSI CCCCCCCCCCCCCCC	31.00	25521595
895	Phosphorylation	AGRLSQGSGSSITAA CCCCCCCCCCCCCHH	28.06	25521595
897	Phosphorylation	RLSQGSGSSITAAGM CCCCCCCCCCCHHHH	21.92	22324799
898	Phosphorylation	LSQGSGSSITAAGMR CCCCCCCCCCHHHHC	27.73	22324799
900	Phosphorylation	QGSGSSITAAGMRLS CCCCCCCCHHHHCHH	16.65	22324799
907	Phosphorylation	TAAGMRLSQMGVTTD CHHHHCHHHCCCCCC	14.04	19060867
912	Phosphorylation	RLSQMGVTTDGVPAQ CHHHCCCCCCCCCHH	17.28	20415495
913	Phosphorylation	LSQMGVTTDGVPAQQ HHHCCCCCCCCCHHH	28.49	29899451
952	Ubiquitination	HGGSSGHGPPSSHHH CCCCCCCCCCCCCCC	39.06	27667366
963	Ubiquitination	SHHHHHHHHHHRGGE CCCCCCCCCCCCCCC	20.02	27667366
982	Phosphorylation	TFAPFHGYSKSEDLS CCCCCCCCCCCCCCC	12.35	29899451
983	O-linked_Glycosylation	FAPFHGYSKSEDLSS CCCCCCCCCCCCCCC	34.01	204022745
983	Phosphorylation	FAPFHGYSKSEDLSS CCCCCCCCCCCCCCC	34.01	-
983	Ubiquitination	FAPFHGYSKSEDLSS CCCCCCCCCCCCCCC	34.01	27667366
985	Phosphorylation	PFHGYSKSEDLSSGV CCCCCCCCCCCCCCC	30.33	19060867
989	Phosphorylation	YSKSEDLSSGVPKPP CCCCCCCCCCCCCCC	37.05	22807455
990	Phosphorylation	SKSEDLSSGVPKPPA CCCCCCCCCCCCCCH	51.62	21082442
993	Ubiquitination	EDLSSGVPKPPAASI CCCCCCCCCCCHHHH	47.14	27667366
994	Ubiquitination	DLSSGVPKPPAASIL CCCCCCCCCCHHHHH	62.32	27667366
1003	Phosphorylation	PAASILHSHSYSDEF CHHHHHHCCCCCCCC	15.64	19060867
1004	Ubiquitination	AASILHSHSYSDEFG HHHHHHCCCCCCCCC	21.73	27667366
1005	Phosphorylation	ASILHSHSYSDEFGP HHHHHCCCCCCCCCC	29.37	19060867
1006	Phosphorylation	SILHSHSYSDEFGPS HHHHCCCCCCCCCCC	18.08	19060867
1007	Phosphorylation	ILHSHSYSDEFGPSG HHHCCCCCCCCCCCC	33.41	29899451
1010	Ubiquitination	SHSYSDEFGPSGTDF CCCCCCCCCCCCCHH	24.38	27667366
1021	Ubiquitination	GTDFTRRQLSLQDSL CCHHHHHHHCHHHHH	31.92	27667366
1023	Phosphorylation	DFTRRQLSLQDSLQH HHHHHHHCHHHHHHH	18.69	21183079
1027	Phosphorylation	RQLSLQDSLQHMLSP HHHCHHHHHHHHHCC	19.57	20415495
1033	Phosphorylation	DSLQHMLSPPQITIG HHHHHHHCCCCEEEC	27.27	20415495
1041	Ubiquitination	PPQITIGPQRPAPSG CCCEEECCCCCCCCC	24.13	27667366
1047	Phosphorylation	GPQRPAPSGPGGGSG CCCCCCCCCCCCCCC	60.78	20415495
1051	Ubiquitination	PAPSGPGGGSGGGSG CCCCCCCCCCCCCCC	30.17	27667366
1052	Ubiquitination	APSGPGGGSGGGSGG CCCCCCCCCCCCCCC	29.09	27667366
1053	Phosphorylation	PSGPGGGSGGGSGGG CCCCCCCCCCCCCCC	37.22	20415495
1055	Ubiquitination	GPGGGSGGGSGGGQP CCCCCCCCCCCCCCC	28.88	27667366
1057	Phosphorylation	GGGSGGGSGGGQPPP CCCCCCCCCCCCCCC	37.22	20415495
1059	Ubiquitination	GSGGGSGGGQPPPLQ CCCCCCCCCCCCCCC	33.01	27667366
1065	Ubiquitination	GGGQPPPLQRGKSQQ CCCCCCCCCCCCCCE	7.18	27667366
1066	Ubiquitination	GGQPPPLQRGKSQQL CCCCCCCCCCCCCEE	58.83	27667366
1068	Ubiquitination	QPPPLQRGKSQQLTV CCCCCCCCCCCEEEE	22.47	27667366
1069	Ubiquitination	PPPLQRGKSQQLTVS CCCCCCCCCCEEEEE	47.48	27667366
1070	Phosphorylation	PPLQRGKSQQLTVSA CCCCCCCCCEEEEEE	26.44	22324799
1074	Phosphorylation	RGKSQQLTVSAAQKP CCCCCEEEEEECCCC	14.21	22807455
1076	Phosphorylation	KSQQLTVSAAQKPRP CCCEEEEEECCCCCC	16.80	29899451
1080	Ubiquitination	LTVSAAQKPRPSSGN EEEEECCCCCCCCCC	37.96	27667366
1090	Ubiquitination	PSSGNLLQSPEPSYG CCCCCCCCCCCCCCC	61.17	27667366
1096	Ubiquitination	LQSPEPSYGPARPRQ CCCCCCCCCCCCCCC	37.53	27667366
1099	Ubiquitination	PEPSYGPARPRQQSL CCCCCCCCCCCCCCC	29.73	27667366
1100	Ubiquitination	EPSYGPARPRQQSLS CCCCCCCCCCCCCCC	30.02	27667366
1105	Phosphorylation	PARPRQQSLSKEGSI CCCCCCCCCCCCCCC	26.69	19060867
1106	Ubiquitination	ARPRQQSLSKEGSIG CCCCCCCCCCCCCCC	8.03	27667366
1108	Ubiquitination	PRQQSLSKEGSIGGS CCCCCCCCCCCCCCC	71.97	22790023
1111	Phosphorylation	QSLSKEGSIGGSGGS CCCCCCCCCCCCCCC	21.10	19060867
1113	Ubiquitination	LSKEGSIGGSGGSGG CCCCCCCCCCCCCCC	26.38	27667366
1115	Phosphorylation	KEGSIGGSGGSGGGG CCCCCCCCCCCCCCC	34.46	20415495
1117	Ubiquitination	GSIGGSGGSGGGGGG CCCCCCCCCCCCCCC	25.47	27667366
1118	Phosphorylation	SIGGSGGSGGGGGGG CCCCCCCCCCCCCCC	37.48	20415495
1123	Ubiquitination	GGSGGGGGGGLKPSI CCCCCCCCCCCCCCC	30.21	27667366
1127	Ubiquitination	GGGGGGLKPSITKQH CCCCCCCCCCCCCCC	39.74	27667366
1131	O-linked_Glycosylation	GGLKPSITKQHSQTP CCCCCCCCCCCCCCC	29.05	55414131
1135	O-linked_Glycosylation	PSITKQHSQTPSTLN CCCCCCCCCCCCCCC	33.00	6729357
1135	Phosphorylation	PSITKQHSQTPSTLN CCCCCCCCCCCCCCC	33.00	29899451
1137	O-linked_Glycosylation	ITKQHSQTPSTLNPT CCCCCCCCCCCCCCC	23.40	8510577
1137	Phosphorylation	ITKQHSQTPSTLNPT CCCCCCCCCCCCCCC	23.40	29899451
1139	O-linked_Glycosylation	KQHSQTPSTLNPTMP CCCCCCCCCCCCCCC	49.25	8510597
1139	Phosphorylation	KQHSQTPSTLNPTMP CCCCCCCCCCCCCCC	49.25	20415495
1140	O-linked_Glycosylation	QHSQTPSTLNPTMPA CCCCCCCCCCCCCCC	31.58	8510591
1140	Phosphorylation	QHSQTPSTLNPTMPA CCCCCCCCCCCCCCC	31.58	21183079
1140	Ubiquitination	QHSQTPSTLNPTMPA CCCCCCCCCCCCCCC	31.58	27667366
1144	Phosphorylation	TPSTLNPTMPASERT CCCCCCCCCCCCHHH	34.41	20415495
1148	O-linked_Glycosylation	LNPTMPASERTVAWV CCCCCCCCHHHEEHH	23.03	68708487
1148	Phosphorylation	LNPTMPASERTVAWV CCCCCCCCHHHEEHH	23.03	20415495
1148	Ubiquitination	LNPTMPASERTVAWV CCCCCCCCHHHEEHH	23.03	27667366
1154	Ubiquitination	ASERTVAWVSNMPHL CCHHHEEHHHCCCCC	6.96	27667366
1156	Phosphorylation	ERTVAWVSNMPHLSA HHHEEHHHCCCCCCC	19.40	20415495
1162	Phosphorylation	VSNMPHLSADIESAH HHCCCCCCCCHHHHH	22.36	21930439
1162	Ubiquitination	VSNMPHLSADIESAH HHCCCCCCCCHHHHH	22.36	27667366
1167	Phosphorylation	HLSADIESAHIEREE CCCCCHHHHHHHHHH	26.02	19060867
1168	Ubiquitination	LSADIESAHIEREEY CCCCHHHHHHHHHHH	8.55	27667366
1171	Ubiquitination	DIESAHIEREEYKLK CHHHHHHHHHHHHHH	44.14	27667366
1176	Ubiquitination	HIEREEYKLKEYSKS HHHHHHHHHHHHHHH	57.26	27667366
1181	Ubiquitination	EYKLKEYSKSMDESR HHHHHHHHHHCCHHH	21.24	27667366
1182	Ubiquitination	YKLKEYSKSMDESRL HHHHHHHHHCCHHHH	49.23	27667366
1183	Phosphorylation	KLKEYSKSMDESRLD HHHHHHHHCCHHHHH	26.06	29899451
1193	Ubiquitination	ESRLDRVKEYEEEIH HHHHHHHHHHHHHHH	56.31	22790023
1195	Phosphorylation	RLDRVKEYEEEIHSL HHHHHHHHHHHHHHH	23.95	20415495
1198	Ubiquitination	RVKEYEEEIHSLKER HHHHHHHHHHHHHHH	33.78	27667366
1201	Phosphorylation	EYEEEIHSLKERLHM HHHHHHHHHHHHHHH	46.96	25521595
1222	Phosphorylation	EYERRLLSQEEQTSK HHHHHHHCHHHHHHH	39.89	20415495
1229	Ubiquitination	SQEEQTSKILMQYQA CHHHHHHHHHHHHHH	43.15	22790023
1243	Ubiquitination	ARLEQSEKRLRQQQV HHHHHHHHHHHHHHH	63.08	27667366
1255	Ubiquitination	QQVEKDSQIKSIIGR HHHHHHHHHHHHHHH	58.21	27667366
1257	Ubiquitination	VEKDSQIKSIIGRLM HHHHHHHHHHHHHHH	28.15	22790023
1258	Phosphorylation	EKDSQIKSIIGRLML HHHHHHHHHHHHHHH	22.52	-
1285	Ubiquitination	AEPLPEPKKRLLDAQ CCCCCCHHHHHHHHH	49.19	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
379	S	Phosphorylation	Kinase	PLK2	P53351	Uniprot
385	S	Phosphorylation	Kinase	PLK2	P53351	Uniprot
449	S	Phosphorylation	Kinase	PLK2	P53351	Uniprot
466	S	Phosphorylation	Kinase	PLK2	P53351	Uniprot
743	S	Phosphorylation	Kinase	CDK5	P49615	PSP
752	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
766	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
780	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
788	S	Phosphorylation	Kinase	CDK5	P49615	PSP
790	T	Phosphorylation	Kinase	CDK5	P49615	PSP
817	S	Phosphorylation	Kinase	CDK5	P49615	PSP
836	S	Phosphorylation	Kinase	PLK2	P53351	Uniprot
840	S	Phosphorylation	Kinase	PLK2	P53351	Uniprot
842	S	Phosphorylation	Kinase	PLK2	P53351	Uniprot
857	S	Phosphorylation	Kinase	CDK5	P49615	PSP
1105	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
1107	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
1111	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
1135	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
1162	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
1222	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SYGP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SYGP1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DLG2_MOUSE	Dlg2	physical	27507650
UBR5_MOUSE	Ubr5	physical	27507650
NMDE2_MOUSE	Grin2b	physical	27507650
NMDZ1_MOUSE	Grin1	physical	27507650
DLGP1_MOUSE	Dlgap1	physical	27507650
KCC2A_MOUSE	Camk2a	physical	27507650
MYO5A_MOUSE	Myo5a	physical	27507650
ANS1B_MOUSE	Anks1b	physical	27507650
NMDE1_MOUSE	Grin2a	physical	27507650
IQEC2_MOUSE	Iqsec2	physical	27507650
KCC2B_MOUSE	Camk2b	physical	27507650
DLG1_MOUSE	Dlg1	physical	27507650
1433Z_MOUSE	Ywhaz	physical	27507650
DLG3_MOUSE	Dlg3	physical	27507650
IQEC1_MOUSE	Iqsec1	physical	27507650
1433G_MOUSE	Ywhag	physical	27507650
1433E_MOUSE	Ywhae	physical	27507650
DPYL2_MOUSE	Dpysl2	physical	27507650
SYN1_MOUSE	Syn1	physical	27507650
SPTB2_MOUSE	Sptbn1	physical	27507650
DLGP2_MOUSE	Dlgap2	physical	27507650
SHAN3_MOUSE	Shank3	physical	27507650
BEGIN_MOUSE	Begain	physical	27507650
RAB3A_MOUSE	Rab3a	physical	27507650
1433F_MOUSE	Ywhah	physical	27507650
BTBD9_MOUSE	Btbd9	physical	27507650
GUAD_MOUSE	Gda	physical	27507650
GNAO_MOUSE	Gnao1	physical	27507650
NMDE4_MOUSE	Grin2d	physical	27507650
GLNA_MOUSE	Glul	physical	27507650
DYHC1_MOUSE	Dync1h1	physical	27507650
CNTP1_MOUSE	Cntnap1	physical	27507650
LRRC7_MOUSE	Lrrc7	physical	27507650
ADA22_MOUSE	Adam22	physical	27507650
FBX2_MOUSE	Fbxo2	physical	27507650
SHAN2_MOUSE	Shank2	physical	27507650
ABLM1_MOUSE	Ablim1	physical	27507650
DLGP3_MOUSE	Dlgap3	physical	27507650
AGRB2_MOUSE	Bai2	physical	27507650
DLGP4_MOUSE	Dlgap4	physical	27507650
RAB3C_MOUSE	Rab3c	physical	27507650
ARF3_MOUSE	Arf3	physical	27507650
SHAN1_MOUSE	Shank1	physical	27507650
CNKR2_MOUSE	Cnksr2	physical	27507650
EAA1_MOUSE	Slc1a3	physical	27507650
RAB1A_MOUSE	Rab1	physical	27507650
CYFP2_MOUSE	Cyfip2	physical	27507650
KPCG_MOUSE	Prkcg	physical	27507650
ADAM9_MOUSE	Adam9	physical	27507650
GRIA1_MOUSE	Gria1	physical	27507650
GRIA2_MOUSE	Gria2	physical	27507650
GRIA3_MOUSE	Gria3	physical	27507650
DEND_MOUSE	Ddn	physical	27507650
KCJ10_MOUSE	Kcnj10	physical	27507650
CTNB1_MOUSE	Ctnnb1	physical	27507650
PRAF2_MOUSE	Praf2	physical	27507650
KPCE_MOUSE	Prkce	physical	27507650
BASP1_MOUSE	Basp1	physical	27507650
RAB2A_MOUSE	Rab2a	physical	27507650
ARF5_MOUSE	Arf5	physical	27507650
CNRP1_MOUSE	Cnrip1	physical	27507650
E41L2_MOUSE	Epb4.1l2	physical	27507650
ANK2_MOUSE	Ank2	physical	27507650
HOME1_MOUSE	Homer1	physical	27507650
KCNA4_MOUSE	Kcna4	physical	27507650
KALRN_MOUSE	Kalrn	physical	27507650
AGAP2_MOUSE	Agap2	physical	27507650
BAIP2_MOUSE	Baiap2	physical	27507650
KCAB2_MOUSE	Kcnab2	physical	27507650
CCG2_MOUSE	Cacng2	physical	27507650
CACB2_MOUSE	Cacnb2	physical	27507650
DGKZ_MOUSE	Dgkz	physical	27507650
PLCL1_MOUSE	Plcl1	physical	27507650
CUL3_MOUSE	Cul3	physical	27507650
AAK1_MOUSE	Aak1	physical	28706196
ABLM1_MOUSE	Ablim1	physical	28706196
ADA22_MOUSE	Adam22	physical	28706196
ADAM9_MOUSE	Adam9	physical	28706196
ARBK2_MOUSE	Adrbk2	physical	28706196
AGAP1_MOUSE	Agap1	physical	28706196
AGAP2_MOUSE	Agap2	physical	28706196
AMPH_MOUSE	Amph	physical	28706196
ANK2_MOUSE	Ank2	physical	28706196
ANS1B_MOUSE	Anks1b	physical	28706196
ARC_MOUSE	Arc	physical	28706196
ARF3_MOUSE	Arf3	physical	28706196
ARF5_MOUSE	Arf5	physical	28706196
RHG32_MOUSE	Arhgap32	physical	28706196
RHG39_MOUSE	Arhgap39	physical	28706196
ASAP2_MOUSE	Asap2	physical	28706196
AGRB2_MOUSE	Bai2	physical	28706196
BAIP2_MOUSE	Baiap2	physical	28706196
BASP1_MOUSE	Basp1	physical	28706196
BEGIN_MOUSE	Begain	physical	28706196
BTBD9_MOUSE	Btbd9	physical	28706196
CACB2_MOUSE	Cacnb2	physical	28706196
CCG2_MOUSE	Cacng2	physical	28706196
KCC2A_MOUSE	Camk2a	physical	28706196
KCC2B_MOUSE	Camk2b	physical	28706196
CAND1_MOUSE	Cand1	physical	28706196
CNRP1_MOUSE	Cnrip1	physical	28706196
CNTP1_MOUSE	Cntnap1	physical	28706196
CUL3_MOUSE	Cul3	physical	28706196
CYFP1_MOUSE	Cyfip1	physical	28706196
CYFP2_MOUSE	Cyfip2	physical	28706196
DREB_MOUSE	Dbn1	physical	28706196
DEND_MOUSE	Ddn	physical	28706196
DGKZ_MOUSE	Dgkz	physical	28706196
DLG1_MOUSE	Dlg1	physical	28706196
DLG2_MOUSE	Dlg2	physical	28706196
DLG3_MOUSE	Dlg3	physical	28706196
DLG4_MOUSE	Dlg4	physical	28706196
DLGP1_MOUSE	Dlgap1	physical	28706196
DLGP2_MOUSE	Dlgap2	physical	28706196
DLGP3_MOUSE	Dlgap3	physical	28706196
DLGP4_MOUSE	Dlgap4	physical	28706196
DYN1_MOUSE	Dnm1	physical	28706196
DNM1L_MOUSE	Dnm1l	physical	28706196
DPYL2_MOUSE	Dpysl2	physical	28706196
DYHC1_MOUSE	Dync1h1	physical	28706196
E41L2_MOUSE	Epb4.1l2	physical	28706196
FA81A_MOUSE	Fam81a	physical	28706196
FBX2_MOUSE	Fbxo2	physical	28706196
GUAD_MOUSE	Gda	physical	28706196
GDIB_MOUSE	Gdi2	physical	28706196
GIT1_MOUSE	Git1	physical	28706196
GLNA_MOUSE	Glul	physical	28706196
GNAO_MOUSE	Gnao1	physical	28706196
GNAS2_MOUSE	Gnas	physical	28706196
ALEX_MOUSE	Gnas	physical	28706196
GNAS1_MOUSE	Gnas	physical	28706196
GNAS3_MOUSE	Gnas	physical	28706196
GNAZ_MOUSE	Gnaz	physical	28706196
GBB1_MOUSE	Gnb1	physical	28706196
GBB2_MOUSE	Gnb2	physical	28706196
GRIA1_MOUSE	Gria1	physical	28706196
GRIA2_MOUSE	Gria2	physical	28706196
GRIA3_MOUSE	Gria3	physical	28706196
NMDZ1_MOUSE	Grin1	physical	28706196
NMDE1_MOUSE	Grin2a	physical	28706196
NMDE2_MOUSE	Grin2b	physical	28706196
NMDE4_MOUSE	Grin2d	physical	28706196
GRM5_MOUSE	Grm5	physical	28706196
GSK3B_MOUSE	Gsk3b	physical	28706196
HOME1_MOUSE	Homer1	physical	28706196
IQGA1_MOUSE	Iqgap1	physical	28706196
IQGA2_MOUSE	Iqgap2	physical	28706196
IQEC1_MOUSE	Iqsec1	physical	28706196
IQEC2_MOUSE	Iqsec2	physical	28706196
IP3KA_MOUSE	Itpka	physical	28706196
KALRN_MOUSE	Kalrn	physical	28706196
KBTBB_MOUSE	Kbtbd11	physical	28706196
KCNA4_MOUSE	Kcna4	physical	28706196
KCAB2_MOUSE	Kcnab2	physical	28706196
KCNB2_MOUSE	Kcnb2	physical	28706196
KCJ10_MOUSE	Kcnj10	physical	28706196
LRRC7_MOUSE	Lrrc7	physical	28706196
MP2K1_MOUSE	Map2k1	physical	28706196
MK01_MOUSE	Mapk1	physical	28706196
MK03_MOUSE	Mapk3	physical	28706196
MTOR_MOUSE	Mtor	physical	28706196
NBEA_MOUSE	Nbea	physical	28706196
NCAM1_MOUSE	Ncam1	physical	28706196
NCAN_MOUSE	Ncan	physical	28706196
NTRK3_MOUSE	Ntrk3	physical	28706196
OPA1_MOUSE	Opa1	physical	28706196
PITM2_MOUSE	Pitpnm2	physical	28706196
PLCL1_MOUSE	Plcl1	physical	28706196
PRAF2_MOUSE	Praf2	physical	28706196
KPCE_MOUSE	Prkce	physical	28706196
KPCG_MOUSE	Prkcg	physical	28706196
FAK2_MOUSE	Ptk2b	physical	28706196
PURA_MOUSE	Pura	physical	28706196
RAB10_MOUSE	Rab10	physical	28706196
RAB2A_MOUSE	Rab2a	physical	28706196
RAB3A_MOUSE	Rab3a	physical	28706196
RAB3C_MOUSE	Rab3c	physical	28706196
RASL1_MOUSE	Rasal1	physical	28706196
SHAN1_MOUSE	Shank1	physical	28706196
SHAN2_MOUSE	Shank2	physical	28706196
SHAN3_MOUSE	Shank3	physical	28706196
SHSA6_MOUSE	Shisa6	physical	28706196
EAA1_MOUSE	Slc1a3	physical	28706196
SRBS1_MOUSE	Sorbs1	physical	28706196
SRBS2_MOUSE	Sorbs2	physical	28706196
SPTB2_MOUSE	Sptbn1	physical	28706196
SRGP2_MOUSE	Srgap2	physical	28706196
STIP1_MOUSE	Stip1	physical	28706196
STRN_MOUSE	Strn	physical	28706196
UBR5_MOUSE	Ubr5	physical	28706196
WDR7_MOUSE	Wdr7	physical	28706196
1433E_MOUSE	Ywhae	physical	28706196
1433G_MOUSE	Ywhag	physical	28706196
1433F_MOUSE	Ywhah	physical	28706196
1433Z_MOUSE	Ywhaz	physical	28706196
ABLM1_MOUSE	Ablim1	physical	28671696
ADA22_MOUSE	Adam22	physical	28671696
ADAM9_MOUSE	Adam9	physical	28671696
AGAP2_MOUSE	Agap2	physical	28671696
ANK2_MOUSE	Ank2	physical	28671696
ANS1B_MOUSE	Anks1b	physical	28671696
ARF3_MOUSE	Arf3	physical	28671696
ARF5_MOUSE	Arf5	physical	28671696
AGRB2_MOUSE	Bai2	physical	28671696
BAIP2_MOUSE	Baiap2	physical	28671696
BASP1_MOUSE	Basp1	physical	28671696
BEGIN_MOUSE	Begain	physical	28671696
BTBD9_MOUSE	Btbd9	physical	28671696
CACB2_MOUSE	Cacnb2	physical	28671696
CCG2_MOUSE	Cacng2	physical	28671696
KCC2A_MOUSE	Camk2a	physical	28671696
KCC2B_MOUSE	Camk2b	physical	28671696
CNRP1_MOUSE	Cnrip1	physical	28671696
CNTP1_MOUSE	Cntnap1	physical	28671696
CUL3_MOUSE	Cul3	physical	28671696
DEND_MOUSE	Ddn	physical	28671696
DGKZ_MOUSE	Dgkz	physical	28671696
DLG1_MOUSE	Dlg1	physical	28671696
DLG2_MOUSE	Dlg2	physical	28671696
DLG3_MOUSE	Dlg3	physical	28671696
DLG4_MOUSE	Dlg4	physical	28671696
DLGP1_MOUSE	Dlgap1	physical	28671696
DLGP2_MOUSE	Dlgap2	physical	28671696
DLGP3_MOUSE	Dlgap3	physical	28671696
DLGP4_MOUSE	Dlgap4	physical	28671696
DPYL2_MOUSE	Dpysl2	physical	28671696
DYHC1_MOUSE	Dync1h1	physical	28671696
E41L2_MOUSE	Epb4.1l2	physical	28671696
FA81A_MOUSE	Fam81a	physical	28671696
FBX2_MOUSE	Fbxo2	physical	28671696
GUAD_MOUSE	Gda	physical	28671696
GLNA_MOUSE	Glul	physical	28671696
GNAO_MOUSE	Gnao1	physical	28671696
GRIA1_MOUSE	Gria1	physical	28671696
GRIA2_MOUSE	Gria2	physical	28671696
GRIA3_MOUSE	Gria3	physical	28671696
NMDZ1_MOUSE	Grin1	physical	28671696
NMDE1_MOUSE	Grin2a	physical	28671696
NMDE2_MOUSE	Grin2b	physical	28671696
NMDE4_MOUSE	Grin2d	physical	28671696
HOME1_MOUSE	Homer1	physical	28671696
IQEC1_MOUSE	Iqsec1	physical	28671696
IQEC2_MOUSE	Iqsec2	physical	28671696
KALRN_MOUSE	Kalrn	physical	28671696
KCNA4_MOUSE	Kcna4	physical	28671696
KCAB2_MOUSE	Kcnab2	physical	28671696
KCJ10_MOUSE	Kcnj10	physical	28671696
LRRC7_MOUSE	Lrrc7	physical	28671696
MYO5A_MOUSE	Myo5a	physical	28671696
PLCL1_MOUSE	Plcl1	physical	28671696
PRAF2_MOUSE	Praf2	physical	28671696
KPCE_MOUSE	Prkce	physical	28671696
KPCG_MOUSE	Prkcg	physical	28671696
PURA_MOUSE	Pura	physical	28671696
RAB10_MOUSE	Rab10	physical	28671696
RAB2A_MOUSE	Rab2a	physical	28671696
RAB3A_MOUSE	Rab3a	physical	28671696
RAB3C_MOUSE	Rab3c	physical	28671696
SHAN1_MOUSE	Shank1	physical	28671696
SHAN2_MOUSE	Shank2	physical	28671696
SHAN3_MOUSE	Shank3	physical	28671696
EAA1_MOUSE	Slc1a3	physical	28671696
SPTB2_MOUSE	Sptbn1	physical	28671696
SYN1_MOUSE	Syn1	physical	28671696
UBR5_MOUSE	Ubr5	physical	28671696
1433E_MOUSE	Ywhae	physical	28671696
1433G_MOUSE	Ywhag	physical	28671696
1433F_MOUSE	Ywhah	physical	28671696
1433Z_MOUSE	Ywhaz	physical	28671696

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SYGP1_MOUSE

Related Literatures of Post-Translational Modification