DGKZ_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DGKZ_MOUSE
• UniProt AC: Q80UP3
• Protein Name: Diacylglycerol kinase zeta
• Gene Name: Dgkz
• Organism: Mus musculus (Mouse).
• Sequence Length: 929
• Subcellular Localization: Cytoplasm . Nucleus . Cell membrane .
• Protein Description: Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Regulates RASGRP1 activity (By similarity)..
• Protein Sequence: MEPRDPSPEGRSSDSESASASSSGSERDAGPEPDKAPRRLTKRRFPGLRLFGHRKAITKSGLQHLAPPPPTPGAPCGESEEQIQSTVDWSESAVYGEHIWFETNVSGDFCYVGEQHCVAKMLPKSAPRKKCAACKIVVHTQCIKQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMMQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRRSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPREALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLRAEPNPEAGPEERDDGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCIVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVLLTTAKAIPVQVDGEPCKLSASRIRIALRNQATMVQKAKRRSTAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQREPDGAGAKSPMCHQLSSKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPASPCSPTPGSMQGDTALPQGEELIEAAKRNDCCKLQELHRAGGDLMHRDQKSRTLLHHAVSTGSKEVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDLQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MEPRDPSPEGRSSD -CCCCCCCCCCCCCC	39.61	22982522
156	Phosphorylation	INFRCKPSFRESGSR CCCCCCCCCCCCCCC	23.56	25168779
160	Phosphorylation	CKPSFRESGSRNVRE CCCCCCCCCCCCCCC	37.50	25168779
162	Phosphorylation	PSFRESGSRNVREPT CCCCCCCCCCCCCCC	29.93	26824392
255	Phosphorylation	RARRPQNTLKASKKK HCCCCCCCCHHCHHH	25.12	29899451
259	Phosphorylation	PQNTLKASKKKKRAS CCCCCHHCHHHHHHH	43.34	30387612
304	Ubiquitination	LLVFVNPKSGGNQGA EEEEECCCCCCHHHH	57.43	-
371	Ubiquitination	TLDQLRLKPPPPVAI HHHHHCCCCCCCEEE	49.39	-
636	Phosphorylation	RSTAPLHSDQQPVPE HCCCCCCCCCCCCCH	44.81	29899451
657	Phosphorylation	SRVSMHDYEALHYDK EEECHHHHHHHCCCH	6.60	29514104
706	Phosphorylation	PDGAGAKSPMCHQLS CCCCCCCCHHHHHCC	19.82	25266776
713	Phosphorylation	SPMCHQLSSKWCFLD CHHHHHCCCCEEEEE	24.25	29514104
782	Phosphorylation	PCSPTPGSMQGDTAL CCCCCCCCCCCCCCC	14.77	-
873	Phosphorylation	AAALGQRTICHYIVE HHHHCCCHHHHHHHH	21.77	20415495
877	Phosphorylation	GQRTICHYIVEAGAS CCCHHHHHHHHHCHH	11.40	20415495
917	Phosphorylation	YLENRQHYQMIQRED HHHHHHHHHHEEHHH	7.46	29514104
927	Phosphorylation	IQREDQETAV----- EEHHHHHCCC-----	27.39	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DGKZ_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DGKZ_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DGKZ_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DGKZ_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.