NMDE4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NMDE4_MOUSE
• UniProt AC: Q03391
• Protein Name: Glutamate receptor ionotropic, NMDA 2D
• Gene Name: Grin2d
• Organism: Mus musculus (Mouse).
• Sequence Length: 1323
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein .
• Protein Description: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). [PubMed: 1385220 Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable]
• Protein Sequence: MRGAGGPRGPRGPAKMLLLLALACASPFPEEVPGPGAAGGGTGGARPLNVALVFSGPAYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLGAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGPGYVWFMVGPQLAGGGGSGVPGEPLLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRAQNRTHRGESLHRYFMNITWDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPSPAYPAARPPPGPAPFVPRERAAADRWRRAKGTGPPGGAALADGFHRYYGPIEPQGLGLGEARAAPRGAAGRPLSPPTTQPPQKPPPSYFAIVREQEPAEPPAGAFPGFPSPPAPPAAAAAAVGPPLCRLAFEDESPPAPSRWPRSDPESQPLLGGGAGGPSAGAPTAPPPRRAAPPPCAYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYPYAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRGGPAWHCRHCASLELLPPPRHLSCSHDGLDGGWWAPPPPPWAAGPPPRRRARCGCPRPHPHRPRASHRAPAAAPHHHRHRRAAGGWDLPPPAPTSRSLEDLSSCPRAAPTRRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGDLGTRRGSAHFSSLESEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
89	N-linked_Glycosylation	RPVALVLNGSDPRSL CCEEEEECCCCHHHH	40.21	-
349	N-linked_Glycosylation	GHDCRAQNRTHRGES CCCCCCCCCCCCCCC	50.24	-
363	N-linked_Glycosylation	SLHRYFMNITWDNRD CHHHHEEECEECCCC	20.74	-
381	N-linked_Glycosylation	NEDGFLVNPSLVVIS CCCCCCCCCEEEEEE	23.69	-
464	N-linked_Glycosylation	VPCRSQLNRTHSPPP CCCHHHCCCCCCCCC	38.89	-
566	N-linked_Glycosylation	SVMVARSNGTVSPSA EEEEEECCCCCCHHH	44.60	-
694	Acetylation	VSGLSDRKFQRPQEQ CCCCCCCCCCCCHHH	51.33	8276437
712	N-linked_Glycosylation	LKFGTVPNGSTEKNI CCCCCCCCCCCCCCH	53.35	-
988	Phosphorylation	GAAGRPLSPPTTQPP CCCCCCCCCCCCCCC	31.36	22817900
991	Phosphorylation	GRPLSPPTTQPPQKP CCCCCCCCCCCCCCC	41.25	22817900
992	Phosphorylation	RPLSPPTTQPPQKPP CCCCCCCCCCCCCCC	44.87	22817900
1049	Phosphorylation	RLAFEDESPPAPSRW EEECCCCCCCCCCCC	48.80	25521595
1054	Phosphorylation	DESPPAPSRWPRSDP CCCCCCCCCCCCCCC	49.43	22324799
1143	Phosphorylation	PPPGRYWSVDKLGGW CCCCCCCEEEECCCC	16.11	22817900
1154	Phosphorylation	LGGWRAGSWDYLPPR CCCCCCCCCCCCCCC	18.78	30372032
1258	Phosphorylation	PPAPTSRSLEDLSSC CCCCCCCCHHHHHCC	35.56	25521595
1275	Phosphorylation	AAPTRRLTGPSRHAR CCCCCCCCCCCHHHH	45.28	25367039
1278	Phosphorylation	TRRLTGPSRHARRCP CCCCCCCCHHHHCCC	37.73	25367039
1303	Methylation	TASHRRHRGGDLGTR CCCCCCCCCCCCCCC	49.32	24129315
1313	Phosphorylation	DLGTRRGSAHFSSLE CCCCCCCCCCHHHCC	19.43	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NMDE4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NMDE4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NMDE4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NMDE4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1313, AND MASSSPECTROMETRY.
PubMed: 16452087