| UniProt ID | RASL1_MOUSE | |
|---|---|---|
| UniProt AC | Q9Z268 | |
| Protein Name | RasGAP-activating-like protein 1 {ECO:0000305} | |
| Gene Name | Rasal1 {ECO:0000312|MGI:MGI:1330842} | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 799 | |
| Subcellular Localization | ||
| Protein Description | Probable inhibitory regulator of the Ras-cyclic AMP pathway. Plays a role in dendrite formation by melanocytes.. | |
| Protein Sequence | MAKSGSLSIRVVEGRALPAKDVSGSSDPYCLVKVDDQVVARTATIWRSLSPFWGEEYTVHLPLDFHHLAFYVLDEDTVGHDDIIGKISLSKEAITADPRGIDSWINLSRVDPDAEVQGEVCLDVKLLEDARGRCLRCHVRQARDLAPRDISGTSDPFARVFWGNHSLETSTIKKTRFPHWDEVLELREAPGTTSPLRVELWDWDMVGKNDFLGMVEFTPQTLQQKPPNGWFRLLPFPRAEDSGGSLGALRLKVRLTEDRVLPSQYYQPLMELLLESVQGPAEEDTTSPLALLEELASGDCRQDLATKLVKLFLGRGLAGPFLDYLTRREVARTNDPNTLFRSNSLASKSMEQFMKLVGMRYLHEVLRPVISRVFEEKKYMELDPCKMDLNRSRRISFKGTPTEEQVRETSLGLLTGYLGSVVDAIVSSTGRCPLALRLAFKQLQRCVEKRFSGIEHQDVKYLAISGFLFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKEQWLAPLHPFLLQSISRVRDFLDQLVDVDEDEEAGGPACALVQPSTIVREGFLLKRKEEPGGLATRFAFKKRYFRLSGRDLSYSKTPEWQVHTSIPLSCIRAVEHVDEGAFQLPHVMQVVTQDGAGTSHTTYLQCKNVNDLNQWLSALRKASAPNPGKLVACHPGAFRSGRWTCCLQAERSAAGCSRTHSAITLGDWSDPLDPDAEAQAVYRQLLLGRDQLRLKLLEDSSLDTEVDPGRDSSATDGPCAEVLAQQRAATTHLLQVLEDLEQAHEEFQKRG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 95 | Phosphorylation | SLSKEAITADPRGID ECCCHHHCCCCCCCC | 31.86 | 20139300 | |
| 144 | Ubiquitination | CHVRQARDLAPRDIS HHHHHHHHCCCCCCC | 50.64 | 27667366 | |
| 166 | Ubiquitination | RVFWGNHSLETSTIK HHCCCCCCCCCCCCC | 31.72 | 27667366 | |
| 216 | Ubiquitination | NDFLGMVEFTPQTLQ CCEECEEEECCHHHC | 34.61 | 27667366 | |
| 242 | Phosphorylation | PFPRAEDSGGSLGAL ECCCCCCCCCCCCEE | 36.24 | 22817900 | |
| 267 | Ubiquitination | VLPSQYYQPLMELLL CCCHHHHHHHHHHHH | 21.51 | 27667366 | |
| 323 | Ubiquitination | GLAGPFLDYLTRREV CCHHHHHHHHHHHHH | 36.45 | 27667366 | |
| 348 | Ubiquitination | RSNSLASKSMEQFMK CCCHHHCHHHHHHHH | 48.49 | 22790023 | |
| 370 | Ubiquitination | HEVLRPVISRVFEEK HHHHHHHHHHHHHCC | 2.11 | 27667366 | |
| 392 | Ubiquitination | CKMDLNRSRRISFKG CCCCCCCCCCCCCCC | 25.49 | 27667366 | |
| 396 | Phosphorylation | LNRSRRISFKGTPTE CCCCCCCCCCCCCCH | 21.06 | 22817900 | |
| 400 | Phosphorylation | RRISFKGTPTEEQVR CCCCCCCCCCHHHHH | 27.85 | 25521595 | |
| 549 | Ubiquitination | DQLVDVDEDEEAGGP HHHCCCCCCCCCCCC | 68.14 | 27667366 | |
| 574 | Ubiquitination | VREGFLLKRKEEPGG HCCCEEEECCCCCCC | 64.67 | 27667366 | |
| 618 | S-palmitoylation | HTSIPLSCIRAVEHV ECCCCHHHHCCEEEC | 3.00 | 28680068 | |
| 748 | Phosphorylation | RLKLLEDSSLDTEVD HHHHHHCCCCCCCCC | 24.35 | 25521595 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RASL1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RASL1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RASL1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of RASL1_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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