dbPTM

KBTBB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KBTBB_MOUSE
UniProt AC	Q8BNW9
Protein Name	Kelch repeat and BTB domain-containing protein 11
Gene Name	Kbtbd11
Organism	Mus musculus (Mouse).
Sequence Length	633
Subcellular Localization
Protein Description
Protein Sequence	MENSVAPFVLYSGTEPRTPGEDSLPLPAEEEGAASTAQTPCSLSASLCFSSGDDSPPQSRASAAEGSEASPPSLRSDLRVVETQWDVSSAASPESPEECARPEEPASPEDPPSRHEHARPVELESLDELGEPVPVPPGVGSVHGEPDLVIEVAGRRLRAHKAVLAARSDYFRARASRDVLRVQGVSFTALRLLLADAYSGRMAGVRPDNVAEVVAGARRLQLPGAAQRATEAMAPQLSLDNCYEVLSAGKRQRLTELRDAAYRFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLCTGRACLLAAALGTTGERSGSRPQSPSGDAESRGDAAVYCYQAEAGEWRELTRLPEGAPARGCGLCVLFNYLFLAGGVAPAGPDGRARPSDQVYCYNPVTDSWSTVRPLRQARSQVQLLALDGHLYAVGGECLLSVERYDPRADRWTAVAPLPRGAFAVAHEAATCNGEIYVSGGSLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFLYRFDLCGSRGEAQAAVGSGGGVSVFRYHCLAKQWSQCAVHLRPPGAPAGLQPFRCVALDGTIYCVSRAGTWRFVPSQDTEAGSDMGPGGSFEPEPLGSPLDVRGVLFPFVLNLPEKPDRGEQGAV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	SVAPFVLYSGTEPRT CCCCEEEEECCCCCC	10.35	-
36	Phosphorylation	EEEGAASTAQTPCSL HHCCCCCCCCCCCEE	20.32	25293948
39	Phosphorylation	GAASTAQTPCSLSAS CCCCCCCCCCEEEEH	24.65	25293948
42	Phosphorylation	STAQTPCSLSASLCF CCCCCCCEEEEHHHC	26.94	25293948
44	Phosphorylation	AQTPCSLSASLCFSS CCCCCEEEEHHHCCC	10.26	25293948
46	Phosphorylation	TPCSLSASLCFSSGD CCCEEEEHHHCCCCC	23.46	25293948
50	Phosphorylation	LSASLCFSSGDDSPP EEEHHHCCCCCCCCC	32.20	25293948
51	Phosphorylation	SASLCFSSGDDSPPQ EEHHHCCCCCCCCCC	26.45	25293948
55	Phosphorylation	CFSSGDDSPPQSRAS HCCCCCCCCCCHHHH	43.13	25293948
59	Phosphorylation	GDDSPPQSRASAAEG CCCCCCCHHHHHHCC	35.27	25293948
62	Phosphorylation	SPPQSRASAAEGSEA CCCCHHHHHHCCCCC	27.23	22324799
67	Phosphorylation	RASAAEGSEASPPSL HHHHHCCCCCCCCCH	22.84	25521595
70	Phosphorylation	AAEGSEASPPSLRSD HHCCCCCCCCCHHHC	33.04	25521595
73	Phosphorylation	GSEASPPSLRSDLRV CCCCCCCCHHHCCEE	39.54	25521595
83	Phosphorylation	SDLRVVETQWDVSSA HCCEEEEEEECCCCC	24.29	20415495
88	Phosphorylation	VETQWDVSSAASPES EEEEECCCCCCCCCC	16.28	20415495
89	Phosphorylation	ETQWDVSSAASPESP EEEECCCCCCCCCCH	27.92	20415495
92	Phosphorylation	WDVSSAASPESPEEC ECCCCCCCCCCHHHH	28.99	22817900
95	Phosphorylation	SSAASPESPEECARP CCCCCCCCHHHHCCC	40.78	25521595
107	Phosphorylation	ARPEEPASPEDPPSR CCCCCCCCCCCCCCC	39.27	22817900
113	Phosphorylation	ASPEDPPSRHEHARP CCCCCCCCCCCCCCC	52.21	20415495
186	Phosphorylation	VLRVQGVSFTALRLL CHHHCCCCHHHHHHH	24.57	29899451
243	Phosphorylation	QLSLDNCYEVLSAGK CCCHHHHHHHHHHCH	18.48	26026062
247	Phosphorylation	DNCYEVLSAGKRQRL HHHHHHHHHCHHHHH	39.90	23737553
314	Phosphorylation	LGTTGERSGSRPQSP HCCCCCCCCCCCCCC	36.50	27087446
316	Phosphorylation	TTGERSGSRPQSPSG CCCCCCCCCCCCCCC	41.87	25521595
320	Phosphorylation	RSGSRPQSPSGDAES CCCCCCCCCCCCCCH	24.58	25521595
322	Phosphorylation	GSRPQSPSGDAESRG CCCCCCCCCCCCHHC	55.33	25521595
327	Phosphorylation	SPSGDAESRGDAAVY CCCCCCCHHCCEEEE	43.19	28833060
336	Phosphorylation	GDAAVYCYQAEAGEW CCEEEEEEECCCCCC	7.96	29899451
390	Glutathionylation	RPSDQVYCYNPVTDS CCCCCEEEECCCCCC	2.51	24333276

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KBTBB_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KBTBB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KBTBB_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of KBTBB_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KBTBB_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70, AND MASSSPECTROMETRY.	17114649 [Abstract]