ADAM9_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADAM9_MOUSE
• UniProt AC: Q61072
• Protein Name: Disintegrin and metalloproteinase domain-containing protein 9
• Gene Name: Adam9 {ECO:0000312|MGI:MGI:105376}
• Organism: Mus musculus (Mouse).
• Sequence Length: 845
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. [PubMed: 19273593 May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins]
• Protein Sequence: MGPRALSPLASLRLRWLLACGLLGPVLEAGRPDLEQTVHLSSYEIITPWRLTRERREALGPSSQQISYVIQAQGKQHIIHLERNTDLLPNDFVVYTYDKEGSLLSDHPNVQSHCHYRGYVEGVQNSAVAVSACFGLRGLLHLENASFGIEPLHNSSHFEHIFYPMDGIHQEPLRCGVSNRDTEKEGTQGDEEEHPSVTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMIRLANYLDSMYIMLNIRIVLVGLEIWTDRNPINIIGGAGDVLGNFVQWREKFLITRWRHDSAQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRECFCGAKSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGSCLLNIPKPDEAYSAPSCGNKLVDPGEECDCGTAKECEVDPCCEGSTCKLKSFAECAYGDCCKDCQFLPGGSMCRGKTSECDVPEYCNGSSQFCPPDVFIQNGYPCQNSKAYCYNGMCQYYDAQCQVIFGSKAKAAPRDCFIEVNSKGDRFGNCGFSGSEYKKCATGNALCGKLQCENVQDMPVFGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCDAGKICRNFQCVNASVLNYDCDIQGKCHGHGVCNSNKNCHCEDGWAPPHCDTKGYGGSVDSGPTYNAKSTALRDGLLVFFFLIVPLVAAAIFLFIKRDELRKTFRKKRSQMSDGRNQANVSRQPGDPSISRPPGGPNVSRPPGGPGVSRPPGGPGVSRPPGGPGVSRPPPGHGNRFPVPTYAAKQPAQFPSRPPPPQPKISSQGNLIPARPAPAPPLYSSLT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MGPRALSPLASLRL -CCCCCCHHHHHHHH	19.51	30635358
11	Phosphorylation	RALSPLASLRLRWLL CCCHHHHHHHHHHHH	23.00	30635358
144	N-linked_Glycosylation	RGLLHLENASFGIEP HHHHEECCCEECCEE	47.44	-
154	N-linked_Glycosylation	FGIEPLHNSSHFEHI ECCEECCCCCCCEEE	53.54	-
231	N-linked_Glycosylation	RYDMMGRNQTAVREE HHHHCCCCHHHHHHH	37.51	-
245	Phosphorylation	EMIRLANYLDSMYIM HHHHHHHHHHHHHHH	13.28	22871156
248	Phosphorylation	RLANYLDSMYIMLNI HHHHHHHHHHHHHHE	15.76	22871156
381	N-linked_Glycosylation	SGASGSRNFSSCSAE CCCCCCCCCCCCCHH	42.73	-
487	N-linked_Glycosylation	CDVPEYCNGSSQFCP CCCCHHCCCCCCCCC	53.10	-
636	N-linked_Glycosylation	CRNFQCVNASVLNYD CCCCEEEEEHHHCEE	33.84	-
735	Phosphorylation	RKKRSQMSDGRNQAN HHHHHHCCCCCCCCC	29.31	25338131
824	Phosphorylation	PPPQPKISSQGNLIP CCCCCCCCCCCCEEC	23.80	24719451
825	Phosphorylation	PPQPKISSQGNLIPA CCCCCCCCCCCEECC	45.65	22499769
841	Phosphorylation	PAPAPPLYSSLT--- CCCCCCCCCCCC---	11.29	22499769
842	Phosphorylation	APAPPLYSSLT---- CCCCCCCCCCC----	26.93	28066266
843	Phosphorylation	PAPPLYSSLT----- CCCCCCCCCC-----	23.59	28066266
845	Phosphorylation	PPLYSSLT------- CCCCCCCC-------	38.21	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADAM9_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADAM9_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADAM9_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ADAM9_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.