ASAP2_MOUSE - dbPTM
ASAP2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ASAP2_MOUSE
UniProt AC Q7SIG6
Protein Name Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
Gene Name Asap2
Organism Mus musculus (Mouse).
Sequence Length 958
Subcellular Localization Cytoplasm. Golgi apparatus, Golgi stack membrane
Peripheral membrane protein. Cell membrane
Peripheral membrane protein. Colocalizes with F-actin and ARF6 in phagocytic cups.
Protein Description Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration (By similarity)..
Protein Sequence MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINISGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEISGAEIAEEMEKERRFFQLQMCEYLLKVNEIKVKKGVDLLQNLIKYFHAQCNFFQDGLKAVESLKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKESRRDSQLRQSTAYSLHQPQGNKEHGTERNGNLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKTNPEEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNIGNAGFNEIMECCLPSEDPVKPNPGSDMIARKDYITAKYMERRYARKKHADTAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDVDEKLQPSPNRREDRPVSFYQLGSSQFQSNAVSLARDTANLTKDKQRGFGPSILQNETYGAILSGSPPSSQSIPPSTTSAPPLPPRNVGKDPLTTTPPPPVAKTSGTLEAMNQPSKSSQPGTSQSKPPPLPPQPPSRLPQKKPASGTDKPTPLTNKGQPRGPEASGPLSNAMALQPPAPMPRKSQATKSKPKRVKALYNCVADNPDELTFSEGDVIIVDGEEDQEWWIGHIDGEPSRKGAFPVSFVHFIAD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMPDQISVSEFVAETH
CCCCCCHHHHHHHHC		20.6622871156
18PhosphorylationVAETHEDYKAPTASS
HHHHCCCCCCCCCCC		13.1822871156
96PhosphorylationRDDPDLGSAFLKFSV
CCCCCHHHHHHHHHH		24.1223140645
212UbiquitinationVNEIKVKKGVDLLQN
HCCCCHHHHHHHHHH		68.13-
288PhosphorylationQKESRRDSQLRQSTA
HHHHHHHHHHHHHHH		29.3329899451
293 (in isoform 2)Phosphorylation-14.4729514104
296PhosphorylationQLRQSTAYSLHQPQG
HHHHHHHHHCCCCCC		16.3229514104
324AcetylationKKSDGIRKVWQKRKC
ECCCCHHHHHHHCCC		46.006569029
328AcetylationGIRKVWQKRKCSVKN
CHHHHHHHCCCEEEC		37.816568843
634PhosphorylationALHYCCLTDNAECLK
HHEEEEECCCHHHHH		17.1922802335
665AcetylationETPLDIAKRLKHEHC
CCHHHHHHHHCHHHH		59.6119856681
668AcetylationLDIAKRLKHEHCEEL
HHHHHHHCHHHHHHH		51.4819856689
701PhosphorylationWRLLHEDLDESDDDV
EEHHHCCCCCCCCCH		7.7824719451
704PhosphorylationLHEDLDESDDDVDEK
HHCCCCCCCCCHHHH		46.1125521595
712PhosphorylationDDDVDEKLQPSPNRR
CCCHHHHCCCCCCCC		9.4724719451
715PhosphorylationVDEKLQPSPNRREDR
HHHHCCCCCCCCCCC		23.1129899451
725PhosphorylationRREDRPVSFYQLGSS
CCCCCCCCEEECCCH		22.4027087446
727PhosphorylationEDRPVSFYQLGSSQF
CCCCCCEEECCCHHH		8.7025521595
740PhosphorylationQFQSNAVSLARDTAN
HHHHHHHHHHHHHCC		17.5624453211
771PhosphorylationETYGAILSGSPPSSQ
CCCCCHHCCCCCHHC		30.9827087446
802PhosphorylationVGKDPLTTTPPPPVA
CCCCCCCCCCCCCCC		45.0129899451
803PhosphorylationGKDPLTTTPPPPVAK
CCCCCCCCCCCCCCC		28.6729899451
814PhosphorylationPVAKTSGTLEAMNQP
CCCCCCCCHHHHCCC		22.6125338131
852PhosphorylationLPQKKPASGTDKPTP
CCCCCCCCCCCCCCC		51.2425338131
861PhosphorylationTDKPTPLTNKGQPRG
CCCCCCCCCCCCCCC		35.77-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ASAP2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ASAP2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ASAP2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ASAP2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ASAP2_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-704, AND MASSSPECTROMETRY.

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