dbPTM

IQEC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IQEC1_MOUSE
UniProt AC	Q8R0S2
Protein Name	IQ motif and SEC7 domain-containing protein 1
Gene Name	Iqsec1
Organism	Mus musculus (Mouse).
Sequence Length	961
Subcellular Localization	Cytoplasm . Nucleus . At steady state, may be preferentially cytosolic.
Protein Description	Guanine nucleotide exchange factor for ARF1 and ARF6. Guanine nucleotide exchange factor activity is enhanced by lipid binding. Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin..
Protein Sequence	MWCLHCNSERTQSLLELELDSGVEGEAPSSETGTSLDSPSAYHQGPLVPGSSLSPDHYEHTSVGAYGLYAGPGPQQRTRRPRLQHSTSVLRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVPSECGDLSDPALKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHSEEVPASDTARARDTEPKPGLHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRSGGAAQDYWALAHKEDKADTDTSCRSTPSLERPEPRLRVEHLPLLTIEPPSDSSVELSDRSDRSSLKRQSAYERSLGGQQGSPKHGPHGGPPKGLPREEPELRPRPPRPLESHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKETRNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGIQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCVCNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPRETLIGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAVPGADIKVLINFNAPNPQDRKKFTDDLRESVAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEFQPFQPPQPPVLCS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23 (in isoform 2)	Phosphorylation	-	11.20	25338131
86	Phosphorylation	RRPRLQHSTSVLRKQ CCCCHHCHHHHHHHH	14.93	23335269
87	Phosphorylation	RPRLQHSTSVLRKQA CCCHHCHHHHHHHHH	22.26	23335269
88	Phosphorylation	PRLQHSTSVLRKQAE CCHHCHHHHHHHHHH	23.36	26824392
102	Phosphorylation	EEEAIKRSRSLSESY HHHHHHHHHCHHHHH	22.63	22324799
104	Phosphorylation	EAIKRSRSLSESYEL HHHHHHHCHHHHHHC	37.18	25521595
106	Phosphorylation	IKRSRSLSESYELSS HHHHHCHHHHHHCCH	26.24	24925903
108	Phosphorylation	RSRSLSESYELSSDL HHHCHHHHHHCCHHH	22.11	24925903
109	Phosphorylation	SRSLSESYELSSDLQ HHCHHHHHHCCHHHH	19.48	25619855
112	Phosphorylation	LSESYELSSDLQDKQ HHHHHHCCHHHHHHH	15.18	25619855
113	Phosphorylation	SESYELSSDLQDKQV HHHHHCCHHHHHHHH	55.77	29899451
147	Phosphorylation	IQTAFRQYQMNKNFE HHHHHHHHHHHHHHH	12.89	29514104
158	Phosphorylation	KNFERLRSSMSENRM HHHHHHHHHHCCCHH	34.68	22324799
159	Phosphorylation	NFERLRSSMSENRMS HHHHHHHHHCCCHHH	21.64	22324799
161	Phosphorylation	ERLRSSMSENRMSRR HHHHHHHCCCHHHHH	33.40	22324799
166	Phosphorylation	SMSENRMSRRIVLSN HHCCCHHHHHHHHHC	18.37	29514104
167	Methylation	MSENRMSRRIVLSNM HCCCHHHHHHHHHCC	24.01	18965443
167	Dimethylation	MSENRMSRRIVLSNM HCCCHHHHHHHHHCC	24.01	-
179	Phosphorylation	SNMRMQFSFEGPEKV HCCEEEEEECCCCCC	12.90	25521595
188	Phosphorylation	EGPEKVHSSYFEGKQ CCCCCCCCCCCCCCE	29.71	29514104
190	Phosphorylation	PEKVHSSYFEGKQVS CCCCCCCCCCCCEEE	14.52	29514104
197	Phosphorylation	YFEGKQVSVTNDGSQ CCCCCEEEECCCCCC	22.26	20415495
199	Phosphorylation	EGKQVSVTNDGSQLG CCCEEEECCCCCCCE	21.78	25521595
203	Phosphorylation	VSVTNDGSQLGALVP EEECCCCCCCEEECC	25.70	20415495
211	Phosphorylation	QLGALVPSECGDLSD CCEEECCHHCCCCCC	37.73	29899451
217	Phosphorylation	PSECGDLSDPALKSP CHHCCCCCCHHHCCC	46.41	29899451
223	Phosphorylation	LSDPALKSPAPSSDF CCCHHHCCCCCCCHH	27.43	27180971
227	Phosphorylation	ALKSPAPSSDFADAI HHCCCCCCCHHHHHH	44.65	29899451
228	Phosphorylation	LKSPAPSSDFADAIT HCCCCCCCHHHHHHH	35.37	29899451
247	Phosphorylation	AFSRQVKSLAESIDD HHHHHHHHHHHHHHH	33.67	22324799
251	Phosphorylation	QVKSLAESIDDALNC HHHHHHHHHHHHHHC	26.22	25521595
260	Phosphorylation	DDALNCRSLHSEEVP HHHHHCHHHCCCCCC	32.41	25521595
263	Phosphorylation	LNCRSLHSEEVPASD HHCHHHCCCCCCHHH	40.52	19060867
269	Phosphorylation	HSEEVPASDTARARD CCCCCCHHHHCCCCC	29.44	20415495
271	Phosphorylation	EEVPASDTARARDTE CCCCHHHHCCCCCCC	18.62	20415495
311	Phosphorylation	YIDEEELSPPLPLSQ EECHHHCCCCCCCHH	27.96	29899451
341	Phosphorylation	SGGAAQDYWALAHKE CCCHHHHHHHHHCCC	4.78	29514104
353	Phosphorylation	HKEDKADTDTSCRST CCCCCCCCCCCCCCC	46.14	22807455
355	Phosphorylation	EDKADTDTSCRSTPS CCCCCCCCCCCCCCC	31.64	22807455
356	Phosphorylation	DKADTDTSCRSTPSL CCCCCCCCCCCCCCC	15.44	19060867
359	Phosphorylation	DTDTSCRSTPSLERP CCCCCCCCCCCCCCC	49.34	21183079
360	Phosphorylation	TDTSCRSTPSLERPE CCCCCCCCCCCCCCC	9.50	19060867
362	Phosphorylation	TSCRSTPSLERPEPR CCCCCCCCCCCCCCC	42.84	24899341
384	Phosphorylation	LLTIEPPSDSSVELS EEEECCCCCCCCCCC	61.92	29899451
386	Phosphorylation	TIEPPSDSSVELSDR EECCCCCCCCCCCCC	40.39	20415495
387	Phosphorylation	IEPPSDSSVELSDRS ECCCCCCCCCCCCCC	25.30	21183079
391	Phosphorylation	SDSSVELSDRSDRSS CCCCCCCCCCCCHHH	19.92	20415495
397	Phosphorylation	LSDRSDRSSLKRQSA CCCCCCHHHHHHHHH	45.04	29899451
398	Phosphorylation	SDRSDRSSLKRQSAY CCCCCHHHHHHHHHH	38.51	23140645
403	Phosphorylation	RSSLKRQSAYERSLG HHHHHHHHHHHHHHC	36.53	29899451
408	Phosphorylation	RQSAYERSLGGQQGS HHHHHHHHHCCCCCC	21.30	25367039
415	Phosphorylation	SLGGQQGSPKHGPHG HHCCCCCCCCCCCCC	26.83	25521595
457	Phosphorylation	NGSANRQSKSESDYS CCCCCCCCCCCCCCC	34.61	26060331
459	Phosphorylation	SANRQSKSESDYSDG CCCCCCCCCCCCCCC	47.80	23684622
461	Phosphorylation	NRQSKSESDYSDGDN CCCCCCCCCCCCCCC	49.27	23684622
463	Phosphorylation	QSKSESDYSDGDNDS CCCCCCCCCCCCCCC	20.24	29899451
464	Phosphorylation	SKSESDYSDGDNDSI CCCCCCCCCCCCCCC	39.86	25521595
470	Phosphorylation	YSDGDNDSINSTSNS CCCCCCCCCCCCCCC	29.89	29899451
473	Phosphorylation	GDNDSINSTSNSNDT CCCCCCCCCCCCCCC	31.38	23684622
474	Phosphorylation	DNDSINSTSNSNDTI CCCCCCCCCCCCCCC	27.69	23684622
507	Phosphorylation	KQTYHKETRNSWDSP CHHCCHHHCCCCCCC	39.70	25521595
510	Phosphorylation	YHKETRNSWDSPAFS CCHHHCCCCCCCCCC	29.03	24925903
513	Phosphorylation	ETRNSWDSPAFSNDV HHCCCCCCCCCCCHH	16.33	25521595
517	Phosphorylation	SWDSPAFSNDVIRKR CCCCCCCCCHHHHHH	33.94	24925903
735	Phosphorylation	VGKKPIGSLHHGLGC HCCCCCCCCCCCCCC	25.83	21183079
795	Phosphorylation	IFQKKKNSVTYSFRQ HHHHCCCCCCEEEEH	25.39	19060867
797	Phosphorylation	QKKKNSVTYSFRQSF HHCCCCCCEEEEHHC	17.17	30635358
798	Phosphorylation	KKKNSVTYSFRQSFS HCCCCCCEEEEHHCE	12.03	30635358
799	Phosphorylation	KKNSVTYSFRQSFSL CCCCCCEEEEHHCEE	12.46	30635358
884	Phosphorylation	QKGVVRPSMSQCSSL CCCCCCCCHHHHHHC	22.09	29899451
886	Phosphorylation	GVVRPSMSQCSSLKK CCCCCCHHHHHHCCC	32.16	29899451
886	O-linked_Glycosylation	GVVRPSMSQCSSLKK CCCCCCHHHHHHCCC	32.16	67331401
889	Phosphorylation	RPSMSQCSSLKKESG CCCHHHHHHCCCCCC	30.94	22324799
890	Phosphorylation	PSMSQCSSLKKESGN CCHHHHHHCCCCCCC	52.41	22324799
899	Phosphorylation	KKESGNGTLSRACLD CCCCCCCCCCHHHHC	26.09	-
908	Phosphorylation	SRACLDDSYASGEGL CHHHHCCCCCCCHHH	23.43	29899451
909	Phosphorylation	RACLDDSYASGEGLK HHHHCCCCCCCHHHH	16.28	29514104
911	Phosphorylation	CLDDSYASGEGLKRS HHCCCCCCCHHHHHH	29.19	29899451
918	Phosphorylation	SGEGLKRSALSSSLR CCHHHHHHHHHHHHH	31.79	22324799
921	Phosphorylation	GLKRSALSSSLRDLS HHHHHHHHHHHHHHH	20.00	24925903
922	Phosphorylation	LKRSALSSSLRDLSE HHHHHHHHHHHHHHH	33.95	24925903
923	Phosphorylation	KRSALSSSLRDLSEA HHHHHHHHHHHHHHH	24.85	25521595
928	Phosphorylation	SSSLRDLSEAGKRGR HHHHHHHHHHHHHCC	29.68	24925903
932	Acetylation	RDLSEAGKRGRRSSA HHHHHHHHHCCCCCC	59.74	7612767
937	Phosphorylation	AGKRGRRSSAGSLES HHHHCCCCCCCCCCC	24.15	21183079
938	Phosphorylation	GKRGRRSSAGSLESN HHHCCCCCCCCCCCC	34.53	21183079
941	Phosphorylation	GRRSSAGSLESNVEF CCCCCCCCCCCCCCC	28.78	21183079
944	Phosphorylation	SSAGSLESNVEFQPF CCCCCCCCCCCCCCC	52.01	29899451
961	Phosphorylation	PQPPVLCS------- CCCCCCCC-------	38.81	20415495

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IQEC1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IQEC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IQEC1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of IQEC1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IQEC1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-510, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106 AND SER-510, ANDMASS SPECTROMETRY.	17242355 [Abstract]
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179 AND SER-513, ANDMASS SPECTROMETRY.	17114649 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-513, AND MASSSPECTROMETRY.	16452087 [Abstract]