DEND_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DEND_MOUSE
• UniProt AC: Q80TS7
• Protein Name: Dendrin
• Gene Name: Ddn
• Organism: Mus musculus (Mouse).
• Sequence Length: 710
• Subcellular Localization: Cell projection, dendritic spine membrane; Peripheral membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Nucleus. Enriched at the cytoplasmic insertion of the slit diaphragm into th
• Protein Description: Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein..
• Protein Sequence: MLDGPLFSEGPDSPRELQDEESGSCLWVQKSKLLVIEVKTISCHYSRRAPSRQSMDIQASYWARGPQSRTCRLRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGGARRSPLGQPRPEPRNALRAAQPTGFPVFSRPERFGQVGRAPRPSVLPQGDPGVAWAGPWGGRRPGPPSYEAHLLLRGSAGTAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPELSRAPTSSAPVPATTRTEGGRTKKRLDPRIYRDVLGAWGLRQGRGLLGGAPGCTAARARPESCKGAIEKSSGLVAAGLNSAGDSHSQGKTTGGPGTDAALSRSAISSPPRPVPRSRQHLRGSRKGKEGSEQIWLPTCWLASPKKPPVRHSQTLPRPWAPGGTGWKESLGQREGAEHETLEVWKVTRRAHTLPRISRGPAGREGIFVIDATCVVIKSQYVPTPRTQQGQLVPSGESCSVSDSLSQPKPCHEEEGEGAAANPSVCQKRLLSSRVLNQPSEGRECEAEVGQQGDSSLEERSSSGLGFPVGEVNPRDAPTQPGSQEHPTLGPAAPVCAGSLKGSEAAGVPRRAGGGWARTPGPYAGALREAVSRIRRHTAPDSDSDEAEDLSVHSGSSDGSDTDAPGASWRNERTLPALGNTRPREGGKTAGLSDSIREIVDVISQTEEGFIREDTRKTPQGNRERE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	LFSEGPDSPRELQDE CCCCCCCCCHHHCCC	29.05	-
51	Phosphorylation	HYSRRAPSRQSMDIQ CCCCCCCCCCCCEEH	41.80	22871156
60	Phosphorylation	QSMDIQASYWARGPQ CCCEEHHHHHHCCCC	12.58	22871156
77	Phosphorylation	TCRLRPGSPEPPPRR CCCCCCCCCCCCCCC	28.86	25521595
88	Phosphorylation	PPRRPWASRVLQEAT CCCCCCHHHHHHHHH	21.03	-
138	Phosphorylation	KAGGARRSPLGQPRP HHCCCCCCCCCCCCC	20.94	29899451
353	Phosphorylation	ALSRSAISSPPRPVP HHHHHHHCCCCCCCC	36.19	24759943
354	Phosphorylation	LSRSAISSPPRPVPR HHHHHHCCCCCCCCC	32.58	29899451
383	Phosphorylation	SEQIWLPTCWLASPK CCEEECCCCEECCCC	17.72	29899451
388	Phosphorylation	LPTCWLASPKKPPVR CCCCEECCCCCCCCC	34.77	19060867
397	Phosphorylation	KKPPVRHSQTLPRPW CCCCCCCCCCCCCCC	17.81	28542873
399	Phosphorylation	PPVRHSQTLPRPWAP CCCCCCCCCCCCCCC	41.57	21183079
442	Phosphorylation	AHTLPRISRGPAGRE HHCCCCCCCCCCCCC	32.25	18056256
547	Phosphorylation	SLEERSSSGLGFPVG CHHHHHCCCCCCCCC	39.00	-
673	Phosphorylation	RPREGGKTAGLSDSI CCCCCCCCCCCCHHH	29.27	25159016
677	Phosphorylation	GGKTAGLSDSIREIV CCCCCCCCHHHHHHH	28.52	25159016
679	Phosphorylation	KTAGLSDSIREIVDV CCCCCCHHHHHHHHH	21.85	25159016

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DEND_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DEND_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DEND_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DEND_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.