KALRN_MOUSE - dbPTM
KALRN_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KALRN_MOUSE
UniProt AC A2CG49
Protein Name Kalirin {ECO:0000250|UniProtKB:P97924}
Gene Name Kalrn {ECO:0000312|MGI:MGI:2685385}
Organism Mus musculus (Mouse).
Sequence Length 2964
Subcellular Localization Cytoplasm . Cytoplasm, cytoskeleton .
Protein Description Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity (By similarity)..
Protein Sequence MVLSGSFRNDGLKASDVLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQHALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQSLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEVLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPTEARDSAMSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIMEVQASGIELICEKDLDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIEKTHQSALQVQQKAEALLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEMDHVIPLLSKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEYYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDREVKLRDANHEINEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRVTKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPIQLPKTPAKLRNNSKRDGVEDGDSQGDGSSQPDTISIASRTSQNTVESDKLSGGCELTVVLQDFSAGHSSELSIQVGQTVELLERPSERPGWCLVRTTERSPPQEGLVPSSALCISHSRSSVEMDCFFPLKDSYSHSSSENGGKSESVAHLQSQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSGKADGNIKKQKKVRDGRKSFDLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSLLAARQAPPDVPTAADLVSAIEKLVKNKLTLEGGSYRGSLKDPTGCLNEGMTPPTPPRNLEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKEKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEDNVDGDPCKFALMNRETSERVILQAANSDIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERSTAVIRSQPPRVPQASPRPYSSGPVGSEKPPKGSSYNPPLPPLKISTSNGSPGFDYHQPGDKFDASKQNDLGGCNGTSTMTVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLAKATAAAESSDGSIKKSCSWHTLRMRKRADVENSGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVLLQCKACGRPKPSITWKGPDQNILDTDNSSATYTISSCDSGESTLKICNLMPQDSGIYTCIAANDHGTASTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPASTGNCTISGYTVEYREEGSQVWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDAAADGATISWKENFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYVTLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQPHNGSYSKIPLDTSRLACFIERRKHQNDVRPIPNVKSYIVNRVNQGTSLSHNP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16 (in isoform 7)Phosphorylation-51.3225338131
26 (in isoform 7)Phosphorylation-15.3629514104
41PhosphorylationKRGGPILTFPARSNH
CCCCCCCEEECCCCC		28.43-
164 (in isoform 4)Phosphorylation-46.3230352176
469PhosphorylationDVLQRPLSPGNSESL
HHHCCCCCCCCCCCC		33.1825521595
473PhosphorylationRPLSPGNSESLTATA
CCCCCCCCCCCEEEE		34.1820415495
475PhosphorylationLSPGNSESLTATANY
CCCCCCCCCEEEECH		30.7320415495
477PhosphorylationPGNSESLTATANYSK
CCCCCCCEEEECHHH		31.1020415495
479PhosphorylationNSESLTATANYSKAV
CCCCCEEEECHHHHH		15.3620415495
482PhosphorylationSLTATANYSKAVHQV
CCEEEECHHHHHHHH		14.7520415495
483PhosphorylationLTATANYSKAVHQVL
CEEEECHHHHHHHHH		17.5920415495
701PhosphorylationPPSLGEPTEARDSAM
CCCCCCCCHHHHHHH		37.6629899451
1093PhosphorylationNRVLHFWTLKKRRLD
CCHHEEEEEHHHCHH		27.9619060867
1147PhosphorylationTQELLKEYGEFRVPA
HHHHHHHHCCCCCCH		21.9929899451
1197PhosphorylationDKHYRDFSLRMGKYR
HHHHHHHHHHCCCCC		21.2522324799
1231PhosphorylationDIIPASLSDREVKLR
EEEECCCCCCEEHHH		31.9329899451
1255AcetylationKRKSARKKEFIMAEL
HHHHHHHHHHHHHHH		52.912387893
1267AcetylationAELLQTEKAYVRDLH
HHHHHHCCHHHHHHH		48.702387901
1310PhosphorylationFGNIQEIYDFHNNIF
ECCHHHHHHHCCCCH		16.29-
1524PhosphorylationFALWSGRTPSSDNKT
EEEEECCCCCCCCCE		30.92-
1572PhosphorylationEPIQLPKTPAKLRNN
CCCCCCCCHHHHCCC		26.9218628310
1580PhosphorylationPAKLRNNSKRDGVED
HHHHCCCCCCCCCCC		32.3925338131
1590PhosphorylationDGVEDGDSQGDGSSQ
CCCCCCCCCCCCCCC		41.4129899451
1595PhosphorylationGDSQGDGSSQPDTIS
CCCCCCCCCCCCEEE		30.4620415495
1596PhosphorylationDSQGDGSSQPDTISI
CCCCCCCCCCCEEEE		51.7921183079
1676PhosphorylationPQEGLVPSSALCISH
CCCCCCCHHHHHHCC		22.2925293948
1677PhosphorylationQEGLVPSSALCISHS
CCCCCCHHHHHHCCC		21.1325293948
1682PhosphorylationPSSALCISHSRSSVE
CHHHHHHCCCCCCCE		17.8925293948
1684PhosphorylationSALCISHSRSSVEMD
HHHHHCCCCCCCEEE		27.3725293948
1686PhosphorylationLCISHSRSSVEMDCF
HHHCCCCCCCEEEEE		41.5726643407
1687PhosphorylationCISHSRSSVEMDCFF
HHCCCCCCCEEEEEE		22.4626643407
1699PhosphorylationCFFPLKDSYSHSSSE
EEEECCCCCCCCCCC		27.2625521595
1700PhosphorylationFFPLKDSYSHSSSEN
EEECCCCCCCCCCCC		22.1225521595
1704PhosphorylationKDSYSHSSSENGGKS
CCCCCCCCCCCCCCC		35.9325521595
1711PhosphorylationSSENGGKSESVAHLQ
CCCCCCCCCCHHHHH		38.0829472430
1713PhosphorylationENGGKSESVAHLQSQ
CCCCCCCCHHHHHCC		31.5329472430
1719PhosphorylationESVAHLQSQPSLNSI
CCHHHHHCCCCHHHC		50.8726643407
1722PhosphorylationAHLQSQPSLNSIHSS
HHHHCCCCHHHCCCC		32.3327742792
1725PhosphorylationQSQPSLNSIHSSPGP
HCCCCHHHCCCCCCC		27.2922324799
1728PhosphorylationPSLNSIHSSPGPKRS
CCHHHCCCCCCCCCC		36.2427742792
1729PhosphorylationSLNSIHSSPGPKRST
CHHHCCCCCCCCCCH		21.5126160508
1744PhosphorylationNTLKKWLTSPVRRLN
HHHHHHHHCHHHHHC		29.8429472430
1745PhosphorylationTLKKWLTSPVRRLNS
HHHHHHHCHHHHHCC		21.1626824392
1752PhosphorylationSPVRRLNSGKADGNI
CHHHHHCCCCCCCCC		46.3829514104
1761AcetylationKADGNIKKQKKVRDG
CCCCCCCCCCCCCCC		64.656571685
1763AcetylationDGNIKKQKKVRDGRK
CCCCCCCCCCCCCCC		63.216571625
1771PhosphorylationKVRDGRKSFDLGSPK
CCCCCCCCCCCCCCC		23.7225521595
1776PhosphorylationRKSFDLGSPKPGDET
CCCCCCCCCCCCCCC		36.7327742792
1783PhosphorylationSPKPGDETTPQGDSA
CCCCCCCCCCCCCCC		48.8225293948
1784PhosphorylationPKPGDETTPQGDSAD
CCCCCCCCCCCCCCC		16.1525293948
1789PhosphorylationETTPQGDSADEKSKK
CCCCCCCCCCHHHCC		44.4325521595
1881PhosphorylationGCLNEGMTPPTPPRN
CCCCCCCCCCCCCCC		36.6526643407
1884PhosphorylationNEGMTPPTPPRNLEE
CCCCCCCCCCCCCCH		47.3225521595
2135PhosphorylationSELLRKGSLTPGYMF
HHHHHCCCCCCCHHC		31.9125619855
2137PhosphorylationLLRKGSLTPGYMFKR
HHHCCCCCCCHHCCC		19.1625619855
2140PhosphorylationKGSLTPGYMFKRSIK
CCCCCCCHHCCCCCC		10.6925619855
2208PhosphorylationDFLNALQSPIEYQRK
HHHHHHHCHHHHHHH		28.7926824392
2219PhosphorylationYQRKERSTAVIRSQP
HHHHHCCCCCHHCCC		31.0328059163
2233PhosphorylationPPRVPQASPRPYSSG
CCCCCCCCCCCCCCC		19.0529472430
2238PhosphorylationQASPRPYSSGPVGSE
CCCCCCCCCCCCCCC		31.3429472430
2239PhosphorylationASPRPYSSGPVGSEK
CCCCCCCCCCCCCCC		41.0729472430
2244PhosphorylationYSSGPVGSEKPPKGS
CCCCCCCCCCCCCCC		42.5628285833
2263PhosphorylationPLPPLKISTSNGSPG
CCCCCEEECCCCCCC		24.9726643407
2264PhosphorylationLPPLKISTSNGSPGF
CCCCEEECCCCCCCC		29.6826643407
2265PhosphorylationPPLKISTSNGSPGFD
CCCEEECCCCCCCCC		32.1926643407
2268PhosphorylationKISTSNGSPGFDYHQ
EEECCCCCCCCCCCC		26.5426643407
2368PhosphorylationAAESSDGSIKKSCSW
HHHCCCCCHHHHCCH		35.9027841257
2374PhosphorylationGSIKKSCSWHTLRMR
CCHHHHCCHHHHHHH		29.05-
2409PhosphorylationDILGNKVSVKETNSS
CCCCCCCCCCCCCCC		29.1320139300
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
1572TPhosphorylationKinaseCDK5Q00535
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KALRN_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KALRN_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ADA22_MOUSEAdam22physical
28706196
ANK2_MOUSEAnk2physical
28706196
KCC2A_MOUSECamk2aphysical
28706196
KCC2B_MOUSECamk2bphysical
28706196
KCC2D_MOUSECamk2dphysical
28706196
KCC2G_MOUSECamk2gphysical
28706196
CAMP3_MOUSECamsap3physical
28706196
CAD10_MOUSECdh10physical
28706196
MIC25_MOUSEChchd6physical
28706196
CTRO_MOUSECitphysical
28706196
CNKR2_MOUSECnksr2physical
28706196
CTNA2_MOUSECtnna2physical
28706196
CTND2_MOUSECtnnd2physical
28706196
DAB2P_MOUSEDab2ipphysical
28706196
DLG2_MOUSEDlg2physical
28706196
DLG4_MOUSEDlg4physical
28706196
DLGP1_MOUSEDlgap1physical
28706196
DZAN1_MOUSEDzank1physical
28706196
E41L3_MOUSEEpb4.1l3physical
28706196
GIT1_MOUSEGit1physical
28706196
CXA1_MOUSEGja1physical
28706196
GRIA2_MOUSEGria2physical
28706196
GRIA3_MOUSEGria3physical
28706196
GRIN1_MOUSEGprin1physical
28706196
NMDE2_MOUSEGrin2bphysical
28706196
HOME1_MOUSEHomer1physical
28706196
AINX_MOUSEInaphysical
28706196
IQEC1_MOUSEIqsec1physical
28706196
IQEC2_MOUSEIqsec2physical
28706196
LZTS3_MOUSELzts3physical
28706196
M3K9_MOUSEMap3k9physical
28706196
MYO5A_MOUSEMyo5aphysical
28706196
NFL_MOUSENeflphysical
28706196
NFM_MOUSENefmphysical
28706196
PDE4D_MOUSEPde4dphysical
28706196
PKP4_MOUSEPkp4physical
28706196
RPGF4_MOUSERapgef4physical
28706196
SESD1_MOUSESestd1physical
28706196
SHAN3_MOUSEShank3physical
28706196
SHSA7_MOUSEShisa7physical
28706196
SI1L1_MOUSESipa1l1physical
28706196
SRBS1_MOUSESorbs1physical
28706196
CYTSA_MOUSESpecc1lphysical
28706196
SPTB2_MOUSESptbn1physical
28706196
SYGP1_MOUSESyngap1physical
28706196
TRIO_MOUSETriophysical
28706196
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KALRN_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1771, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1722 AND SER-1771, ANDMASS SPECTROMETRY.

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