SESD1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SESD1_MOUSE
• UniProt AC: Q80UK0
• Protein Name: SEC14 domain and spectrin repeat-containing protein 1
• Gene Name: Sestd1
• Organism: Mus musculus (Mouse).
• Sequence Length: 696
• Protein Description: May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1 (By similarity)..
• Protein Sequence: MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCLEQTSMDELSVTLDYLLSIPSEKCKARGFTVIVDGRKSQWNVVKTVVLMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELALINNGSDKGNEQEKERSVDLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDASQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTVASEERVHRLEMAIAFHSNAEKILQDCPEEPEAMNDEEQFEEIEAIGKSLLDRLTIPVVYPDGTEQYFGSPSDMASTAEHIRDRMKLVSLKRQQLRHPELVTTES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
184	Phosphorylation	LALINNGSDKGNEQE HHHHCCCCCCCCHHH	37.97	25338131
253	Phosphorylation	QVMKLLDSLREQYTR HHHHHHHHHHHHHHH	29.33	24719451
258	Phosphorylation	LDSLREQYTRYQEVC HHHHHHHHHHHHHHH	6.61	24719451
272	Phosphorylation	CRQRSKRTQLEEIQQ HHHHHHHHHHHHHHH	41.04	21659604
543	Ubiquitination	VLLEKHRKFVDVAQS HHHHHHHHHHHHHHH	49.84	22790023
550	Phosphorylation	KFVDVAQSTYDYGRQ HHHHHHHHHHHHHHH	21.14	-
551	Phosphorylation	FVDVAQSTYDYGRQL HHHHHHHHHHHHHHH	14.34	-
552	Phosphorylation	VDVAQSTYDYGRQLL HHHHHHHHHHHHHHH	16.65	-
554	Phosphorylation	VAQSTYDYGRQLLQA HHHHHHHHHHHHHHH	12.09	-
677	Acetylation	EHIRDRMKLVSLKRQ HHHHHHHHHHHHHHH	46.78	23864654
682	Acetylation	RMKLVSLKRQQLRHP HHHHHHHHHHHHCCC	40.43	23576753

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SESD1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SESD1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SESD1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COF1_HUMAN	CFL1	physical	26496610
LPP_HUMAN	LPP	physical	26496610
PRDX5_HUMAN	PRDX5	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.