| UniProt ID | LZTS3_MOUSE | |
|---|---|---|
| UniProt AC | A2AHG0 | |
| Protein Name | Leucine zipper putative tumor suppressor 3 {ECO:0000305} | |
| Gene Name | Lzts3 {ECO:0000312|MGI:MGI:2656976} | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 700 | |
| Subcellular Localization | Cell junction, synapse . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cytoplasm, cytoskeleton . Detected at synapses, postsynaptic density, synaptic spines and dendrites. Rather found at excitatory than inhibitory synaps | |
| Protein Description | May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses.. | |
| Protein Sequence | MAPADLASEGPKLEDPPAPHLFGKCPSGLIMAKLETLPVRADPGRDPLLAFAPRPSELGPPDPRLTMGSVGSGVTHAQEFPMKSVGTRTGGGGNQGSFPGPRSGGSGANRERPGRYPSEDKVLANSLYLNGELRGSDHTDVCGNVVGSSGGSSSSGGSDKAPPQYREPNHPPKLLTTSGKLDQCSEPLVRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPAGLKGGLDKSRTMTPAGGSGGGLSDSGRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTAGYSSGSSGGGSGYQDLGTSDSGRASSKSGSSSSMGRSGHLGSGEGGNGGLPFAACSPPSPSALIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAAQLIRQREELEDKVAVCQKEQADFLPRMEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFGSKQASLELSEGELPPACLKPALTPVDLVEPQEALASCESDEAKMRRQAGVAAAASLVSVDGEVEAGGEGGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGSSTPTPQHGEEKKAWTPSRLERIESTEI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 66 | Phosphorylation | GPPDPRLTMGSVGSG CCCCCCCCCCCCCCC | 29899451 | ||
| 69 | Phosphorylation | DPRLTMGSVGSGVTH CCCCCCCCCCCCCCC | 29899451 | ||
| 72 | Phosphorylation | LTMGSVGSGVTHAQE CCCCCCCCCCCCCCC | 29899451 | ||
| 75 | O-linked_Glycosylation | GSVGSGVTHAQEFPM CCCCCCCCCCCCCCC | 55413467 | ||
| 75 | Phosphorylation | GSVGSGVTHAQEFPM CCCCCCCCCCCCCCC | 29899451 | ||
| 97 | Phosphorylation | GGGGNQGSFPGPRSG CCCCCCCCCCCCCCC | 28285833 | ||
| 118 | Phosphorylation | ERPGRYPSEDKVLAN CCCCCCCCCCCEECE | 29899451 | ||
| 204 | Phosphorylation | VVPKNFHSMQNLCPP CCCCCHHHHHHCCCC | - | ||
| 237 | Phosphorylation | LDKSRTMTPAGGSGG CCCCCCCCCCCCCCC | 28973931 | ||
| 249 | Phosphorylation | SGGGLSDSGRNSLTS CCCCCCCCCCCCCCC | 21189417 | ||
| 255 | Phosphorylation | DSGRNSLTSLPTYSS CCCCCCCCCCCCCCC | 29472430 | ||
| 256 | Phosphorylation | SGRNSLTSLPTYSSS CCCCCCCCCCCCCCC | 29472430 | ||
| 259 | Phosphorylation | NSLTSLPTYSSSYSQ CCCCCCCCCCCCCCH | 29472430 | ||
| 260 | Phosphorylation | SLTSLPTYSSSYSQH CCCCCCCCCCCCCHH | 29472430 | ||
| 261 | Phosphorylation | LTSLPTYSSSYSQHL CCCCCCCCCCCCHHC | 29472430 | ||
| 262 | Phosphorylation | TSLPTYSSSYSQHLA CCCCCCCCCCCHHCC | 29472430 | ||
| 263 | Phosphorylation | SLPTYSSSYSQHLAP CCCCCCCCCCHHCCC | 29472430 | ||
| 264 | Phosphorylation | LPTYSSSYSQHLAPL CCCCCCCCCHHCCCC | 29472430 | ||
| 265 | Phosphorylation | PTYSSSYSQHLAPLS CCCCCCCCHHCCCCC | 29472430 | ||
| 272 | Phosphorylation | SQHLAPLSASTSHIN CHHCCCCCCCCCCCC | 29472430 | ||
| 274 | Phosphorylation | HLAPLSASTSHINRI HCCCCCCCCCCCCCE | 21082442 | ||
| 275 | Phosphorylation | LAPLSASTSHINRIG CCCCCCCCCCCCCEE | 29472430 | ||
| 276 | Phosphorylation | APLSASTSHINRIGT CCCCCCCCCCCCEEE | 29472430 | ||
| 286 | Phosphorylation | NRIGTAGYSSGSSGG CCEEECCCCCCCCCC | 25777480 | ||
| 290 | Phosphorylation | TAGYSSGSSGGGSGY ECCCCCCCCCCCCCC | 25777480 | ||
| 291 | Phosphorylation | AGYSSGSSGGGSGYQ CCCCCCCCCCCCCCC | 25777480 | ||
| 295 | Phosphorylation | SGSSGGGSGYQDLGT CCCCCCCCCCCCCCC | 25777480 | ||
| 302 | Phosphorylation | SGYQDLGTSDSGRAS CCCCCCCCCCCCCCC | 25777480 | ||
| 321 | Phosphorylation | SSSSMGRSGHLGSGE CCCCCCCCCCCCCCC | 23984901 | ||
| 326 | Phosphorylation | GRSGHLGSGEGGNGG CCCCCCCCCCCCCCC | 23984901 | ||
| 340 | Phosphorylation | GLPFAACSPPSPSAL CCCCCCCCCCCHHHH | 19060867 | ||
| 343 | Phosphorylation | FAACSPPSPSALIQE CCCCCCCCHHHHHHH | 26239621 | ||
| 345 | Phosphorylation | ACSPPSPSALIQELE CCCCCCHHHHHHHHH | 16141072 | ||
| 466 | Acetylation | LPRMEETKWEVCQKA HHHHHHHHHHHHHHH | 7720251 | ||
| 486 | Phosphorylation | LKQQLKDSQADVSQK HHHHHHHCCCHHHHH | 24899341 | ||
| 524 | Phosphorylation | QLLSLRDSFGSKQAS HHHHHHHHHCCCCCE | 29899451 | ||
| 638 | Ubiquitination | VWLEEKEKVIEYQKQ HHHHHHHHHHHHHHH | 22790023 | ||
| 673 | Phosphorylation | ERGAAGGSSTPTPQH HCCCCCCCCCCCCCC | 23684622 | ||
| 674 | Phosphorylation | RGAAGGSSTPTPQHG CCCCCCCCCCCCCCC | 24899341 | ||
| 675 | Phosphorylation | GAAGGSSTPTPQHGE CCCCCCCCCCCCCCC | 23684622 | ||
| 677 | Phosphorylation | AGGSSTPTPQHGEEK CCCCCCCCCCCCCHH | 23684622 | ||
| 688 | Phosphorylation | GEEKKAWTPSRLERI CCHHCCCCHHHHHHH | 28973931 | ||
| 690 | Phosphorylation | EKKAWTPSRLERIES HHCCCCHHHHHHHHC | 22324799 | ||
| 697 | Phosphorylation | SRLERIESTEI---- HHHHHHHCCCC---- | 24759943 | ||
| 698 | Phosphorylation | RLERIESTEI----- HHHHHHCCCC----- | 24759943 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LZTS3_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LZTS3_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LZTS3_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of LZTS3_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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