KCC2G_MOUSE - dbPTM
KCC2G_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KCC2G_MOUSE
UniProt AC Q923T9
Protein Name Calcium/calmodulin-dependent protein kinase type II subunit gamma
Gene Name Camk2g
Organism Mus musculus (Mouse).
Sequence Length 529
Subcellular Localization Sarcoplasmic reticulum membrane
Peripheral membrane protein
Cytoplasmic side .
Protein Description Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning (By similarity)..
Protein Sequence MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationTATCTRFTDDYQLFE
CCCCCCCCCCHHHHH		25.3525338131
14PhosphorylationCTRFTDDYQLFEELG
CCCCCCCHHHHHHHC		15.2125338131
26PhosphorylationELGKGAFSVVRRCVK
HHCCCHHHHHHHHCC		21.1118056256
35PhosphorylationVRRCVKKTSTQEYAA
HHHHCCCCCCHHHHH		31.1525619855
36PhosphorylationRRCVKKTSTQEYAAK
HHHCCCCCCHHHHHH		36.6525619855
37PhosphorylationRCVKKTSTQEYAAKI
HHCCCCCCHHHHHHH		30.5625619855
40PhosphorylationKKTSTQEYAAKIINT
CCCCCHHHHHHHHCC		11.3125619855
43UbiquitinationSTQEYAAKIINTKKL
CCHHHHHHHHCCCCC		35.6322790023
48UbiquitinationAAKIINTKKLSARDH
HHHHHCCCCCCHHHH		47.4222790023
48AcetylationAAKIINTKKLSARDH
HHHHHCCCCCCHHHH		47.427768463
49UbiquitinationAKIINTKKLSARDHQ
HHHHCCCCCCHHHHH		45.71-
69UbiquitinationARICRLLKHPNIVRL
HHHHHHHCCCCEEEE		62.70-
79PhosphorylationNIVRLHDSISEEGFH
CEEEECCCCCCCCCE		19.78-
138UbiquitinationDIVHRDLKPENLLLA
CCCCCCCCHHHHHHH		55.35-
146PhosphorylationPENLLLASKCKGAAV
HHHHHHHHCCCCCCC		38.2622817900
147UbiquitinationENLLLASKCKGAAVK
HHHHHHHCCCCCCCH		34.07-
182PhosphorylationAGTPGYLSPEVLRKD
CCCCCCCCHHHHHCC		15.5523737553
227UbiquitinationHKLYQQIKAGAYDFP
HHHHHHHHHCCCCCC		36.11-
231PhosphorylationQQIKAGAYDFPSPEW
HHHHHCCCCCCCCCH		19.7324925903
235PhosphorylationAGAYDFPSPEWDTVT
HCCCCCCCCCHHCCC		35.1324925903
240PhosphorylationFPSPEWDTVTPEAKN
CCCCCHHCCCHHHHH		27.6124925903
242PhosphorylationSPEWDTVTPEAKNLI
CCCHHCCCHHHHHHH		19.9424925903
246UbiquitinationDTVTPEAKNLINQML
HCCCHHHHHHHHHHH		51.10-
254PhosphorylationNLINQMLTINPAKRI
HHHHHHHCCCHHHCC		17.2325521595
259UbiquitinationMLTINPAKRITADQA
HHCCCHHHCCCHHHH		45.66-
268UbiquitinationITADQALKHPWVCQR
CCHHHHHCCCCHHCH		51.1122790023
276PhosphorylationHPWVCQRSTVASMMH
CCCHHCHHHHHHHHH		11.0125521595
277PhosphorylationPWVCQRSTVASMMHR
CCHHCHHHHHHHHHH		23.4525521595
280PhosphorylationCQRSTVASMMHRQET
HCHHHHHHHHHHHHH		16.5925521595
287PhosphorylationSMMHRQETVECLRKF
HHHHHHHHHHHHHHH		17.1726824392
301MethylationFNARRKLKGAILTTM
HHHHHHHHHHHHHHH		49.70-
306PhosphorylationKLKGAILTTMLVSRN
HHHHHHHHHHHHHCC		12.2120415495
307PhosphorylationLKGAILTTMLVSRNF
HHHHHHHHHHHHCCH		12.6925521595
311PhosphorylationILTTMLVSRNFSAAK
HHHHHHHHCCHHHHH		19.9725521595
315PhosphorylationMLVSRNFSAAKSLLN
HHHHCCHHHHHHHHH		30.7626824392
319 (in isoform 3)Phosphorylation-33.1026824392
319 (in isoform 2)Phosphorylation-33.1029514104
319PhosphorylationRNFSAAKSLLNKKSD
CCHHHHHHHHHHCCC		33.1025162660
325 (in isoform 2)Phosphorylation-43.0025338131
325 (in isoform 3)Phosphorylation-43.0030352176
325PhosphorylationKSLLNKKSDGGVKKR
HHHHHHCCCCCCCCC		43.0025338131
334 (in isoform 3)Phosphorylation-39.2126824392
334PhosphorylationGGVKKRKSSSSVHLM
CCCCCCCCCCCEEEC		39.2122324799
335 (in isoform 3)Phosphorylation-29.6627742792
335PhosphorylationGVKKRKSSSSVHLMP
CCCCCCCCCCEEECC		29.6622324799
336PhosphorylationVKKRKSSSSVHLMPQ
CCCCCCCCCEEECCC		43.3922324799
337PhosphorylationKKRKSSSSVHLMPQS
CCCCCCCCEEECCCC		18.5922324799
347 (in isoform 3)Phosphorylation-52.7625521595
348 (in isoform 3)Phosphorylation-42.5725521595
349PhosphorylationPQSNNKNSLVSPAQE
CCCCCCCCCCCCCCC		31.5822210690
350 (in isoform 3)Phosphorylation-6.5525521595
352PhosphorylationNNKNSLVSPAQEPAP
CCCCCCCCCCCCCCC		21.5822210690
368PhosphorylationQTAMEPQTTVVHNAT
CCCCCCCEEEEECCC		32.0729550500
369PhosphorylationTAMEPQTTVVHNATD
CCCCCCEEEEECCCC		18.4523684622
375PhosphorylationTTVVHNATDGIKGST
EEEEECCCCCCCCCC		39.8226643407
381PhosphorylationATDGIKGSTESCNTT
CCCCCCCCCCCCCCC		24.8125521595
382PhosphorylationTDGIKGSTESCNTTT
CCCCCCCCCCCCCCC		40.3525521595
384PhosphorylationGIKGSTESCNTTTED
CCCCCCCCCCCCCCC		16.8625521595
387PhosphorylationGSTESCNTTTEDEDL
CCCCCCCCCCCCCCH		39.1525521595
388PhosphorylationSTESCNTTTEDEDLK
CCCCCCCCCCCCCHH		17.7525521595
389PhosphorylationTESCNTTTEDEDLKV
CCCCCCCCCCCCHHH		39.1325521595
455PhosphorylationFYFENLLSKNSKPIH
HHHHHHHCCCCCCCE		32.7222324799
497PhosphorylationDGQGRPRTSQSEETR
CCCCCCCCCCCCCCE		33.5322807455
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KCC2G_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
287TPhosphorylation

16452087
287TPhosphorylation

16452087
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KCC2G_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of KCC2G_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KCC2G_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-235 AND THR-287, ANDMASS SPECTROMETRY.

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