dbPTM

DZAN1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DZAN1_MOUSE
UniProt AC	Q8C008
Protein Name	Double zinc ribbon and ankyrin repeat-containing protein 1
Gene Name	Dzank1
Organism	Mus musculus (Mouse).
Sequence Length	778
Subcellular Localization
Protein Description
Protein Sequence	MTAGSVCAPQIIPLRVPQPGKANHEIDTNTLLEMKSDTPDVNIYYTLDGSKPDFLKKVGSGENNTFKYVKPITLPDGKIQVKAVAVSKDCRQSGIVTKVFQVDYEPPKMVSSEDNVEDALKGFSKQELKNGFVGPKLRKKYKNAENKSTWNVNLRRLADLKVGERADPKTLKDLRFAESPLEIPAYHEGASARLPTHQAQSPGFAHITGQKSLTSTEIMRIQRETDFLKCAHCLASRPSDPFARFCHECGAPVPPIFGYRLPPPEGAQMGLCAECGSMVPMNTPICVVCEAPLAPQLRPQASLYLKERVICRTCGTGNPAHLRYCVTCEGPLPPTQEQWLCNGDEVPHPPARNGETISCSRCGCQNLWEASFCDWCGAMLGISASHSVCPKCGASNHLTARFCGSCGIYVKSITRFRMHNSLAIVAGAPRPFPEPRSAWQSLNVPLPTSASGSKKDTGTQTSGLFYPSGKLLAKKELEAASHRQRQEKMSDHRPVLTAVSPGRGYWRKQLDHISAHLRSYAQNNPEFRALIAEPRMGKLISATVHEDGYEVSIRLNYIQVSNKSLYFNKSVNLSDHFLSSVTEGGNGLYDSRSSLVSAYSQSVSDTPESIKKMKNLKAKSFLVNPEPLTPENKLLLEEVGSSGKGRLSVLEQLLDEGADPNCCDSQGRPAVIVAVVNKHYEAIPVLAQRGADIDQQWGPFRNTALHEATLLGLEGRESIATLLGCNANAQKKNTRGQTAYDIALEMGDDLTSSLFAAKFTQGLEDQLSPPGNRILGDS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	Ubiquitination	PITLPDGKIQVKAVA CEECCCCCEEEEEEE	37.03	-
179	Phosphorylation	KDLRFAESPLEIPAY HHHHCCCCCCCCCCC	31.21	22817900
201	Phosphorylation	LPTHQAQSPGFAHIT CCCCCCCCCCCEEEC	29.97	29899451
212	Phosphorylation	AHITGQKSLTSTEIM EEECCCCCCCHHHHH	29.06	29899451
259	Phosphorylation	PVPPIFGYRLPPPEG CCCCCCCCCCCCCCC	9.76	-
470	Ubiquitination	GLFYPSGKLLAKKEL CCCCCCCCCHHHHHH	44.67	-
500	Phosphorylation	RPVLTAVSPGRGYWR CCEEEEECCCCCHHH	21.12	29899451
505	Phosphorylation	AVSPGRGYWRKQLDH EECCCCCHHHHHHHH	10.73	-
563	Ubiquitination	NYIQVSNKSLYFNKS EEEEECCCEEEECCC	34.04	-
570	Phosphorylation	KSLYFNKSVNLSDHF CEEEECCCCCCCHHH	19.83	29899451
619	Ubiquitination	KMKNLKAKSFLVNPE HHCCCCCCEECCCCC	39.90	-
620	Phosphorylation	MKNLKAKSFLVNPEP HCCCCCCEECCCCCC	28.77	29899451
641	Phosphorylation	LLLEEVGSSGKGRLS EEHHHHCCCCCCHHH	40.88	29899451
642	Phosphorylation	LLEEVGSSGKGRLSV EHHHHCCCCCCHHHH	38.30	20415495
768	Phosphorylation	QGLEDQLSPPGNRIL CCHHHHCCCCCCCCC	24.34	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DZAN1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DZAN1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DZAN1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DZAN1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DZAN1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-768, AND MASSSPECTROMETRY.	16452087 [Abstract]