UniProt ID | M3K9_MOUSE | |
---|---|---|
UniProt AC | Q3U1V8 | |
Protein Name | Mitogen-activated protein kinase kinase kinase 9 | |
Gene Name | Map3k9 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 1077 | |
Subcellular Localization | ||
Protein Description | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis (By similarity).. | |
Protein Sequence | MESSRSLLGCLASATAAPPGDDATGAGAEEEEDEEEAAAELGSHAALPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGAEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWAGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTSILDQLTTIEESGFFEMPKDSFHCLQDDWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLISNRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELTSGDEGLKSLVDGYKQWSSSAPNLGKGPRSSPALPGFTSLMEIEDEDSEGPGSGENHQQHSPNQSYLCIPFPRGEDGDGPSSDGVHEEPTPVNSATSTPQLTPTNSLKRGGTHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPPEEPEPPAREEKKRREGLFQRASRPRRSTSPPSRKLFKKEEPMTLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLTQCTHNPLVNVRVERFKRDPNQSLTPTHVTLTAPTQPSGHRRTPSDGALKPTAAPAVLGSRSPSSNGMSPSPGTGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQRDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSASPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPLQAGPLLPAERTLLDLDAEGQSQDSTVPLCRAELNAHGPSPYEIQQEFWS | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
|
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
297 | Phosphorylation | LAREWHRTTKMSAAG HHHHHHHCCCCCCCC | 20.20 | - | |
298 | Phosphorylation | AREWHRTTKMSAAGT HHHHHHCCCCCCCCH | 25.38 | - | |
301 | Phosphorylation | WHRTTKMSAAGTYAW HHHCCCCCCCCHHHH | 19.27 | 21183079 | |
305 | Phosphorylation | TKMSAAGTYAWMAPE CCCCCCCHHHHHCHH | 12.82 | 29899451 | |
306 | Phosphorylation | KMSAAGTYAWMAPEV CCCCCCHHHHHCHHH | 9.43 | 20469934 | |
512 | Phosphorylation | LKDGNRISLPSDFQH CCCCCEECCCCCCCC | 30.87 | 21743459 | |
515 | Phosphorylation | GNRISLPSDFQHKFT CCEECCCCCCCCCEE | 57.24 | 21743459 | |
522 | Phosphorylation | SDFQHKFTVQASPTM CCCCCCEEEEECCCC | 19.26 | 28576409 | |
526 | Phosphorylation | HKFTVQASPTMDKRK CCEEEEECCCCHHHH | 12.10 | 26239621 | |
528 | Phosphorylation | FTVQASPTMDKRKSL EEEEECCCCHHHHHH | 35.19 | 29899451 | |
540 | Phosphorylation | KSLISNRSSPPASPT HHHHHCCCCCCCCCC | 51.99 | 22817900 | |
541 | Phosphorylation | SLISNRSSPPASPTI HHHHCCCCCCCCCCC | 31.50 | 22817900 | |
545 | Phosphorylation | NRSSPPASPTIIPRL CCCCCCCCCCCHHCE | 28.49 | 20139300 | |
547 | Phosphorylation | SSPPASPTIIPRLRA CCCCCCCCCHHCEEE | 29.10 | 22817900 | |
558 | Phosphorylation | RLRAIQLTPGESSKT CEEEEECCCCCCCCC | 16.93 | 26487105 | |
563 | Phosphorylation | QLTPGESSKTWGRSS ECCCCCCCCCCCCCC | 29.78 | 26487105 | |
586 | Ubiquitination | EEEKRAPKKKGRTWG HHHHHCCCCCCCCCC | 67.16 | - | |
620 | Phosphorylation | VDGYKQWSSSAPNLG HHHHHHHHCCCCCCC | 16.36 | 29899451 | |
621 | Phosphorylation | DGYKQWSSSAPNLGK HHHHHHHCCCCCCCC | 27.79 | 24719451 | |
622 | Phosphorylation | GYKQWSSSAPNLGKG HHHHHHCCCCCCCCC | 42.08 | 29514104 | |
777 | Phosphorylation | RASRPRRSTSPPSRK HHCCCCCCCCCCCHH | 34.22 | 29550500 | |
778 | Phosphorylation | ASRPRRSTSPPSRKL HCCCCCCCCCCCHHH | 43.36 | 29550500 | |
779 | Phosphorylation | SRPRRSTSPPSRKLF CCCCCCCCCCCHHHC | 35.74 | 29550500 | |
782 | Phosphorylation | RRSTSPPSRKLFKKE CCCCCCCCHHHCCCC | 45.49 | 29550500 | |
793 | Phosphorylation | FKKEEPMTLLGDPSA CCCCCCCEECCCCCH | 29.55 | - | |
815 | Phosphorylation | SSISECNSTRSLLRS HHHHHCCCCHHHHHC | 36.53 | 21183079 | |
830 | Phosphorylation | DSDEIVVYEMPVSPV CCCCEEEEECCCCCC | 8.80 | 26060331 | |
835 | Phosphorylation | VVYEMPVSPVEAPPL EEEECCCCCCCCCCC | 19.84 | 26060331 | |
843 | Phosphorylation | PVEAPPLTQCTHNPL CCCCCCCCCCCCCCC | 27.63 | 26060331 | |
846 | Phosphorylation | APPLTQCTHNPLVNV CCCCCCCCCCCCEEE | 18.18 | 26060331 | |
887 | Phosphorylation | SGHRRTPSDGALKPT CCCCCCCCCCCCCCC | 48.33 | 26239621 | |
984 | Phosphorylation | LDPWWFVSPSHARSA CCCEEEECHHHCCCC | 15.94 | 25177544 | |
986 | Phosphorylation | PWWFVSPSHARSASP CEEEECHHHCCCCCC | 23.44 | 25177544 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of M3K9_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference |
---|---|---|---|---|
297 | T | Phosphorylation |
| - |
301 | S | Phosphorylation |
| - |
305 | T | Phosphorylation |
| - |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of M3K9_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of M3K9_MOUSE !! |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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