M3K9_MOUSE - dbPTM
M3K9_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID M3K9_MOUSE
UniProt AC Q3U1V8
Protein Name Mitogen-activated protein kinase kinase kinase 9
Gene Name Map3k9
Organism Mus musculus (Mouse).
Sequence Length 1077
Subcellular Localization
Protein Description Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis (By similarity)..
Protein Sequence MESSRSLLGCLASATAAPPGDDATGAGAEEEEDEEEAAAELGSHAALPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGAEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWAGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTSILDQLTTIEESGFFEMPKDSFHCLQDDWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLISNRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELTSGDEGLKSLVDGYKQWSSSAPNLGKGPRSSPALPGFTSLMEIEDEDSEGPGSGENHQQHSPNQSYLCIPFPRGEDGDGPSSDGVHEEPTPVNSATSTPQLTPTNSLKRGGTHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPPEEPEPPAREEKKRREGLFQRASRPRRSTSPPSRKLFKKEEPMTLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLTQCTHNPLVNVRVERFKRDPNQSLTPTHVTLTAPTQPSGHRRTPSDGALKPTAAPAVLGSRSPSSNGMSPSPGTGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQRDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSASPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPLQAGPLLPAERTLLDLDAEGQSQDSTVPLCRAELNAHGPSPYEIQQEFWS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
297PhosphorylationLAREWHRTTKMSAAG
HHHHHHHCCCCCCCC
20.20-
298PhosphorylationAREWHRTTKMSAAGT
HHHHHHCCCCCCCCH
25.38-
301PhosphorylationWHRTTKMSAAGTYAW
HHHCCCCCCCCHHHH
19.2721183079
305PhosphorylationTKMSAAGTYAWMAPE
CCCCCCCHHHHHCHH
12.8229899451
306PhosphorylationKMSAAGTYAWMAPEV
CCCCCCHHHHHCHHH
9.4320469934
512PhosphorylationLKDGNRISLPSDFQH
CCCCCEECCCCCCCC
30.8721743459
515PhosphorylationGNRISLPSDFQHKFT
CCEECCCCCCCCCEE
57.2421743459
522PhosphorylationSDFQHKFTVQASPTM
CCCCCCEEEEECCCC
19.2628576409
526PhosphorylationHKFTVQASPTMDKRK
CCEEEEECCCCHHHH
12.1026239621
528PhosphorylationFTVQASPTMDKRKSL
EEEEECCCCHHHHHH
35.1929899451
540PhosphorylationKSLISNRSSPPASPT
HHHHHCCCCCCCCCC
51.9922817900
541PhosphorylationSLISNRSSPPASPTI
HHHHCCCCCCCCCCC
31.5022817900
545PhosphorylationNRSSPPASPTIIPRL
CCCCCCCCCCCHHCE
28.4920139300
547PhosphorylationSSPPASPTIIPRLRA
CCCCCCCCCHHCEEE
29.1022817900
558PhosphorylationRLRAIQLTPGESSKT
CEEEEECCCCCCCCC
16.9326487105
563PhosphorylationQLTPGESSKTWGRSS
ECCCCCCCCCCCCCC
29.7826487105
586UbiquitinationEEEKRAPKKKGRTWG
HHHHHCCCCCCCCCC
67.16-
620PhosphorylationVDGYKQWSSSAPNLG
HHHHHHHHCCCCCCC
16.3629899451
621PhosphorylationDGYKQWSSSAPNLGK
HHHHHHHCCCCCCCC
27.7924719451
622PhosphorylationGYKQWSSSAPNLGKG
HHHHHHCCCCCCCCC
42.0829514104
777PhosphorylationRASRPRRSTSPPSRK
HHCCCCCCCCCCCHH
34.2229550500
778PhosphorylationASRPRRSTSPPSRKL
HCCCCCCCCCCCHHH
43.3629550500
779PhosphorylationSRPRRSTSPPSRKLF
CCCCCCCCCCCHHHC
35.7429550500
782PhosphorylationRRSTSPPSRKLFKKE
CCCCCCCCHHHCCCC
45.4929550500
793PhosphorylationFKKEEPMTLLGDPSA
CCCCCCCEECCCCCH
29.55-
815PhosphorylationSSISECNSTRSLLRS
HHHHHCCCCHHHHHC
36.5321183079
830PhosphorylationDSDEIVVYEMPVSPV
CCCCEEEEECCCCCC
8.8026060331
835PhosphorylationVVYEMPVSPVEAPPL
EEEECCCCCCCCCCC
19.8426060331
843PhosphorylationPVEAPPLTQCTHNPL
CCCCCCCCCCCCCCC
27.6326060331
846PhosphorylationAPPLTQCTHNPLVNV
CCCCCCCCCCCCEEE
18.1826060331
887PhosphorylationSGHRRTPSDGALKPT
CCCCCCCCCCCCCCC
48.3326239621
984PhosphorylationLDPWWFVSPSHARSA
CCCEEEECHHHCCCC
15.9425177544
986PhosphorylationPWWFVSPSHARSASP
CEEEECHHHCCCCCC
23.4425177544

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of M3K9_MOUSE !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
297TPhosphorylation

-
301SPhosphorylation

-
305TPhosphorylation

-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of M3K9_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of M3K9_MOUSE !!

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of M3K9_MOUSE

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Related Literatures of Post-Translational Modification

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