| UniProt ID | DLG4_MOUSE | |
|---|---|---|
| UniProt AC | Q62108 | |
| Protein Name | Disks large homolog 4 | |
| Gene Name | Dlg4 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 724 | |
| Subcellular Localization |
Cell membrane Lipid-anchor Cytoplasmic side . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cell junction, synapse . Cytoplasm . Cell projection, axon . High levels in postsynaptic density of neurons in the forebrain. |
|
| Protein Description | Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (Probable).. | |
| Protein Sequence | MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKIIEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFHFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | S-palmitoylation | -----MDCLCIVTTK -----CCEEEEEECC | 3.01 | 18836441 | |
| 5 | S-palmitoylation | ---MDCLCIVTTKKY ---CCEEEEEECCCE | 2.71 | 18836441 | |
| 19 | Phosphorylation | YRYQDEDTPPLEHSP EECCCCCCCCCCCCC | 25.43 | 16337919 | |
| 25 | Phosphorylation | DTPPLEHSPAHLPNQ CCCCCCCCCCCCCCC | 17.88 | 16337919 | |
| 67 | Phosphorylation | EMEYEEITLERGNSG EEEEEEEEEECCCCC | 26.33 | - | |
| 73 | Phosphorylation | ITLERGNSGLGFSIA EEEECCCCCCCEEEC | 37.91 | 19060867 | |
| 78 | Phosphorylation | GNSGLGFSIAGGTDN CCCCCCEEECCCCCC | 15.10 | 20415495 | |
| 83 | Phosphorylation | GFSIAGGTDNPHIGD CEEECCCCCCCCCCC | 31.52 | 29899451 | |
| 93 | Phosphorylation | PHIGDDPSIFITKII CCCCCCCCEEEEEEC | 36.81 | 20415495 | |
| 97 | Phosphorylation | DDPSIFITKIIPGGA CCCCEEEEEECCCCH | 12.87 | 20415495 | |
| 129 | Phosphorylation | EVDVREVTHSAAVEA EEEHHHHCHHHHHHH | 12.83 | 20415495 | |
| 131 | Phosphorylation | DVREVTHSAAVEALK EHHHHCHHHHHHHHH | 14.46 | 25521595 | |
| 138 | Ubiquitination | SAAVEALKEAGSIVR HHHHHHHHHHCCEEE | 53.19 | 22790023 | |
| 138 (in isoform 2) | Ubiquitination | - | 53.19 | 22790023 | |
| 142 | Phosphorylation | EALKEAGSIVRLYVM HHHHHHCCEEEEEEE | 25.59 | 22817900 | |
| 162 | Ubiquitination | AEKIIEIKLIKGPKG HHHEEEEEEEECCCC | 31.22 | 22790023 | |
| 162 (in isoform 2) | Ubiquitination | - | 31.22 | 22790023 | |
| 168 | Ubiquitination | IKLIKGPKGLGFSIA EEEEECCCCCCEEEC | 75.36 | - | |
| 181 (in isoform 2) | Ubiquitination | - | 29.92 | - | |
| 202 | Ubiquitination | IEGGAAHKDGRLQIG EECCCCCCCCCCCCC | 58.09 | 22790023 | |
| 202 | Neddylation | IEGGAAHKDGRLQIG EECCCCCCCCCCCCC | 58.09 | - | |
| 202 (in isoform 2) | Ubiquitination | - | 58.09 | 22790023 | |
| 205 (in isoform 2) | Ubiquitination | - | 33.29 | - | |
| 217 | Phosphorylation | DKILAVNSVGLEDVM CEEEEEECCCHHHHC | 15.80 | - | |
| 236 | Phosphorylation | VAALKNTYDVVYLKV HHHHHCCEEEEEEEE | 19.01 | 29899451 | |
| 240 | Phosphorylation | KNTYDVVYLKVAKPS HCCEEEEEEEEECCC | 10.72 | 25521595 | |
| 242 | Ubiquitination | TYDVVYLKVAKPSNA CEEEEEEEEECCCCC | 23.59 | 22790023 | |
| 242 (in isoform 2) | Ubiquitination | - | 23.59 | 22790023 | |
| 245 (in isoform 2) | Ubiquitination | - | 52.55 | - | |
| 285 (in isoform 2) | Ubiquitination | - | 8.71 | - | |
| 289 | Phosphorylation | YPTAMTPTSPRRYSP CCCCCCCCCCCCCCH | 42.04 | 29899451 | |
| 290 | Phosphorylation | PTAMTPTSPRRYSPV CCCCCCCCCCCCCHH | 20.01 | 19060867 | |
| 294 | Phosphorylation | TPTSPRRYSPVAKDL CCCCCCCCCHHHHHH | 20.71 | 25521595 | |
| 295 | Phosphorylation | PTSPRRYSPVAKDLL CCCCCCCCHHHHHHC | 15.87 | 25521595 | |
| 299 | Ubiquitination | RRYSPVAKDLLGEED CCCCHHHHHHCCCCC | 49.49 | 22790023 | |
| 299 (in isoform 2) | Ubiquitination | - | 49.49 | 22790023 | |
| 342 (in isoform 2) | Ubiquitination | - | 3.23 | - | |
| 355 | Ubiquitination | DLSGELRKGDQILSV CCCCCCCCCCEEEEE | 78.46 | 22790023 | |
| 355 (in isoform 2) | Ubiquitination | - | 78.46 | 22790023 | |
| 397 | Phosphorylation | AQYKPEEYSRFEAKI EEECHHHHHHHHHHH | 11.95 | 29899451 | |
| 398 | Phosphorylation | QYKPEEYSRFEAKIH EECHHHHHHHHHHHH | 33.50 | 29899451 | |
| 398 (in isoform 2) | Ubiquitination | - | 33.50 | - | |
| 403 | Ubiquitination | EYSRFEAKIHDLREQ HHHHHHHHHHHHHHH | 33.12 | 22790023 | |
| 403 (in isoform 2) | Ubiquitination | - | 33.12 | 22790023 | |
| 414 | Phosphorylation | LREQLMNSSLGSGTA HHHHHHHCCCCCCCC | 16.99 | 22324799 | |
| 415 | Phosphorylation | REQLMNSSLGSGTAS HHHHHHCCCCCCCCH | 31.57 | 25521595 | |
| 418 | Phosphorylation | LMNSSLGSGTASLRS HHHCCCCCCCCHHCC | 37.96 | 25521595 | |
| 420 | Phosphorylation | NSSLGSGTASLRSNP HCCCCCCCCHHCCCC | 18.12 | 25521595 | |
| 422 | Phosphorylation | SLGSGTASLRSNPKR CCCCCCCHHCCCCCC | 24.93 | 25521595 | |
| 425 | Phosphorylation | SGTASLRSNPKRGFY CCCCHHCCCCCCCEE | 63.88 | 25521595 | |
| 432 | Phosphorylation | SNPKRGFYIRALFDY CCCCCCEEEEEEECC | 7.72 | 15572359 | |
| 439 | Phosphorylation | YIRALFDYDKTKDCG EEEEEECCCCCCCCC | 16.41 | 29899451 | |
| 441 (in isoform 2) | Ubiquitination | - | 51.77 | 22790023 | |
| 441 | Ubiquitination | RALFDYDKTKDCGFL EEEECCCCCCCCCHH | 51.77 | 22790023 | |
| 442 | Phosphorylation | ALFDYDKTKDCGFLS EEECCCCCCCCCHHH | 29.26 | - | |
| 446 (in isoform 2) | Ubiquitination | - | 36.34 | - | |
| 449 | Phosphorylation | TKDCGFLSQALSFHF CCCCCHHHHHHHCCC | 15.90 | - | |
| 478 | Phosphorylation | WQARRVHSDSETDDI HHHHCCCCCCCCCCC | 39.72 | 22324799 | |
| 480 | Phosphorylation | ARRVHSDSETDDIGF HHCCCCCCCCCCCCC | 45.47 | 25521595 | |
| 482 | Phosphorylation | RVHSDSETDDIGFIP CCCCCCCCCCCCCCC | 42.81 | 29899451 | |
| 484 (in isoform 2) | Ubiquitination | - | 50.78 | - | |
| 490 | Phosphorylation | DDIGFIPSKRRVERR CCCCCCCCCHHHCHH | 33.70 | 20415495 | |
| 505 | Ubiquitination | EWSRLKAKDWGSSSG HHHHHCCHHCCCCCC | 53.04 | - | |
| 509 | Phosphorylation | LKAKDWGSSSGSQGR HCCHHCCCCCCCCCC | 19.65 | 20415495 | |
| 510 | Phosphorylation | KAKDWGSSSGSQGRE CCHHCCCCCCCCCCC | 34.48 | 20415495 | |
| 511 | Phosphorylation | AKDWGSSSGSQGRED CHHCCCCCCCCCCCC | 44.13 | 20415495 | |
| 513 | Phosphorylation | DWGSSSGSQGREDSV HCCCCCCCCCCCCCC | 31.26 | 25521595 | |
| 558 (in isoform 2) | Ubiquitination | - | 52.44 | 22790023 | |
| 558 | Ubiquitination | LLSEFPDKFGSCVPH HHHHCCCCCCCCCCC | 52.44 | 22790023 | |
| 561 | Phosphorylation | EFPDKFGSCVPHTTR HCCCCCCCCCCCCCC | 18.31 | - | |
| 566 | Phosphorylation | FGSCVPHTTRPKREY CCCCCCCCCCCCCEE | 20.59 | - | |
| 580 | Phosphorylation | YEIDGRDYHFVSSRE EEECCCCEEEECCHH | 8.87 | 29899451 | |
| 584 | Phosphorylation | GRDYHFVSSREKMEK CCCEEEECCHHHHHH | 23.80 | 29899451 | |
| 585 | Phosphorylation | RDYHFVSSREKMEKD CCEEEECCHHHHHHH | 38.87 | 29899451 | |
| 588 | Ubiquitination | HFVSSREKMEKDIQA EEECCHHHHHHHHHH | 51.77 | - | |
| 591 | Ubiquitination | SSREKMEKDIQAHKF CCHHHHHHHHHHHHH | 57.54 | - | |
| 601 (in isoform 2) | Ubiquitination | - | 12.94 | - | |
| 604 | Phosphorylation | KFIEAGQYNSHLYGT HHHHHCCCCCCCCCC | 20.09 | 29899451 | |
| 606 | Phosphorylation | IEAGQYNSHLYGTSV HHHCCCCCCCCCCCH | 15.22 | 29899451 | |
| 609 | Phosphorylation | GQYNSHLYGTSVQSV CCCCCCCCCCCHHHH | 16.97 | 18034455 | |
| 654 | Phosphorylation | AIFIRPRSLENVLEI EEEECCCCHHHHHHH | 42.59 | 25521595 | |
| 663 (in isoform 2) | Ubiquitination | - | 51.33 | 22790023 | |
| 663 | Ubiquitination | ENVLEINKRITEEQA HHHHHHHHHCCHHHH | 51.33 | 22790023 | |
| 672 | Acetylation | ITEEQARKAFDRATK CCHHHHHHHHHHHHH | 57.32 | 7714093 | |
| 706 (in isoform 2) | Ubiquitination | - | 37.32 | - | |
| 715 | Phosphorylation | IEDLSGPYIWVPARE HHHHCCCEEEEECHH | 15.79 | 20415495 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DLG4_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DLG4_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DLG4_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-240; SER-415 ANDSER-418, AND MASS SPECTROMETRY. | |
| "Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-142; TYR-240 ANDSER-295, AND MASS SPECTROMETRY. | |
| "Proteomic analysis of in vivo phosphorylated synaptic proteins."; Collins M.O., Yu L., Coba M.P., Husi H., Campuzano I.,Blackstock W.P., Choudhary J.S., Grant S.G.; J. Biol. Chem. 280:5972-5982(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-415; SER-418 ANDTYR-432, AND MASS SPECTROMETRY. | |
| "Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain."; Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.; J. Proteome Res. 7:311-318(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-240; TYR-397; TYR-580;TYR-604 AND TYR-715, AND MASS SPECTROMETRY. | |
