CNTN1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNTN1_MOUSE
• UniProt AC: P12960
• Protein Name: Contactin-1
• Gene Name: Cntn1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1020
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor.
• Protein Description: Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth..
• Protein Sequence: MKMPLLVSHLLLISLTSCLGDFTWHRRYGHGVSEEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTNDRYSMVGGNLVINNPDKQKDAGVYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVKVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVESSDRGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDIYTMMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGLYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCIATGKPIPTIRWLKNGYSYHKGELRLYDVTFENAGMYQCIAENAYGSIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITNPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKEITHIHYQRNFMLDANGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMESAKAVDLIPWMEYEFRVVATNTLGTGEPSIPSNRIKTDGAAPNVAPSDVGGGGGTNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMTPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWKHVLEKIVESYQIRYWAGHDKEAAAHRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPSSDVIETFTRKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKILYRPDGQHDGKLFSTHKHSIEVPIPRDGEYVVEVRAHSDGGDGVVSQVKISGVSTLSSSLLSLLLPSLGFLVYSEF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	RRYGHGVSEEDKGFG HHCCCCCCHHHCCCC	39.60	29899451
105	Ubiquitination	LVINNPDKQKDAGVY EEECCCCCCCCCCEE	61.58	-
208	N-linked_Glycosylation	VESSDRGNYSCFVSS CCCCCCCCEEEEECC	26.83	-
238	Ubiquitination	PIPERTTKPYPADIV CCCCCCCCCCCCCEE	41.77	27667366
258	N-linked_Glycosylation	IYTMMGQNVTLECFA HHHHCCCCEEEEEEE	24.02	-
338	N-linked_Glycosylation	PEWVEHINDTEVDIG HHHHHHCCCCCCCCC	52.65	-
457	N-linked_Glycosylation	KGTEWLVNSSRILIW CCCEEEECCCCEEEE	31.90	-
473	N-linked_Glycosylation	DGSLEINNITRNDGG CCCEEEECEEECCCC	42.54	-
494	N-linked_Glycosylation	ENNRGKANSTGTLVI ECCCCCCCCCEEEEE	43.52	-
521	N-linked_Glycosylation	ADITVGENATMQCAA CCEECCCCCHHCEEH	34.48	-
593	N-linked_Glycosylation	TAQTIVDNSSASADL EEEEEECCCCCCCCE	27.28	-
621	Phosphorylation	IEDIRATSVALTWSR HHHEEEEEEEEEEEC	12.38	21189417
627	Phosphorylation	TSVALTWSRGSDNHS EEEEEEEECCCCCCC	22.87	21189417
703	Phosphorylation	IPSNRIKTDGAAPNV CCCCCCCCCCCCCCC	36.98	25777480
713	Phosphorylation	AAPNVAPSDVGGGGG CCCCCCCCCCCCCCC	34.88	25777480
721	Phosphorylation	DVGGGGGTNRELTIT CCCCCCCCCCEEEEE	34.08	25777480
935	N-linked_Glycosylation	DHVVALSNESTVTGY CEEEECCCCCEECEE	48.35	-
1001	GPI-anchor	ISGVSTLSSSLLSLL ECCCHHHCHHHHHHH	20.26	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CNTN1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNTN1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNTN1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CNTN1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.