dbPTM

KIF3A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KIF3A_MOUSE
UniProt AC	P28741
Protein Name	Kinesin-like protein KIF3A
Gene Name	Kif3a
Organism	Mus musculus (Mouse).
Sequence Length	701
Subcellular Localization	Cytoplasm, cytoskeleton . Cell projection, cilium . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Localizes to the subdistal appendage region of the centriole.
Protein Description	Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. [PubMed: 21670265 Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitement of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole]
Protein Sequence	MPINKSEKPESCDNVKVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHKTDSSNEPPKTFTFDTVFGPESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGLRGVIPNSFAHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMHVRMGKLHLVDLAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEVSGSDISGSEEDDEEGELGEDGEKKKKRRDQAGKKKVSPDKMVEMQAKIDEERKALETKLDMEEEERNKARAELERREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLEESNMELEERRRRAEQLRKELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPQDYQEMIENYVHWNEDIGEWQLKCVAYTGNNMRKQTPVPDKKERDPFEVDLSHVYLAYTEESLRQSLMKLERPRTSKGKARPKMGRRKRSAKPETVIDSLLQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	Phosphorylation	SSNEPPKTFTFDTVF CCCCCCCEEEEEEEE	33.41	22871156
245	Acetylation	NMHVRMGKLHLVDLA CEEEEECEEEEEECC	24.32	19857849
259	Acetylation	AGSERQAKTGATGQR CCCHHHHHCCCCCHH	38.87	19857857
356	Ubiquitination	ARINEDPKDALLRQF CCCCCCHHHHHHHHH	68.87	-
371	Acetylation	QKEIEELKKKLEEGE HHHHHHHHHHHHCCC	51.66	6569401
372	Acetylation	KEIEELKKKLEEGEE HHHHHHHHHHHCCCC	75.19	6568963
381	Phosphorylation	LEEGEEVSGSDISGS HHCCCCCCCCCCCCC	35.54	28973931
383	Phosphorylation	EGEEVSGSDISGSEE CCCCCCCCCCCCCCC	25.02	28973931
386	Phosphorylation	EVSGSDISGSEEDDE CCCCCCCCCCCCCCC	41.06	28973931
388	Phosphorylation	SGSDISGSEEDDEEG CCCCCCCCCCCCCCC	30.90	28973931
417	Phosphorylation	QAGKKKVSPDKMVEM HHCCCCCCHHHHHHH	35.94	-
433	Acetylation	AKIDEERKALETKLD HHHHHHHHHHHHHCC	61.68	2389673
469	Phosphorylation	KAQQEHQSLLEKLSA HHHHHHHHHHHHHHH	36.51	30635358
553	Phosphorylation	KKLKKVWTMLMAAKS HHHHHHHHHHHHHHH	11.92	-
635	Phosphorylation	GNNMRKQTPVPDKKE CCCCCCCCCCCCCCC	29.32	24899341
674	Phosphorylation	MKLERPRTSKGKARP HHCCCCCCCCCCCCC	37.16	-
675	Phosphorylation	KLERPRTSKGKARPK HCCCCCCCCCCCCCC	40.46	25338131
689	Phosphorylation	KMGRRKRSAKPETVI CCCCCCCCCCCHHHH	43.62	25521595
694	Phosphorylation	KRSAKPETVIDSLLQ CCCCCCHHHHHHHHC	31.15	25619855
698	Phosphorylation	KPETVIDSLLQ---- CCHHHHHHHHC----	21.61	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
674	T	Phosphorylation	Kinase	ICK	Q9JKV2	PSP
689	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
694	T	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
698	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KIF3A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KIF3A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PR15A_MOUSE	Ppp1r15a	physical	10631107
TNKS1_MOUSE	Tnks	physical	22473005
AXIN1_MOUSE	Axin1	physical	22473005

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KIF3A_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-689, AND MASSSPECTROMETRY.	15345747 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-635, AND MASSSPECTROMETRY.	19367708 [Abstract]