PR15A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PR15A_MOUSE
• UniProt AC: P17564
• Protein Name: Protein phosphatase 1 regulatory subunit 15A
• Gene Name: Ppp1r15a
• Organism: Mus musculus (Mouse).
• Sequence Length: 657
• Subcellular Localization: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side . Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side . Associates with membranes via an N-terminal amphipathic intramembrane region.
• Protein Description: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. In case of infection with vesicular stomatitis virus (VSV), impairs viral replication..
• Protein Sequence: MAPSPRPQHVLHWRDAHNFYLLSPLMGLLSRAWSRLRGPEVPEAWLAKTVTGADQIEAAALLTPTPVSGNLLPHGETEESGSPEQSQAAQRLCLVEAESSPPETWGLSNVDEYNAKPGQDDLREKEMERTAGKATLQPAGLQGADKRLGEVVAREEGVAEPAYPTSQLEGGPAENEEDGETVKTYQASAASIAPGYKPSTPVPFLGEAEHQATEEKGTENKADPSNSPSSGSHSRAWEYYSREKPKQEGEAKVEAHRAGQGHPCRNAEAEEGGPETTFVCTGNAFLKAWVYRPGEDTEEEDNSDSDSAEEDTAQTGATPHTSAFLKAWVYRPGEDTEEEDSDSDSAEEDTAQTGATPHTSAFLKAWVYRPGEDTEEENSDLDSAEEDTAQTGATPHTSAFLKAWVYRPGEDTEEENSDLDSAEEDTAQTGATPHTSPFLKAWVYRPGEDTEDDTEEEEDSENVAPGDSETADSSQSPCLQPQRCLPGEKTKGRGEEPPLFQVAFYLPGEKPESPWAAPKLPLRLQRRLRLFKAPTRDQDPEIPLKARKVHFAEKVTVHFLAVWAGPAQAARRGPWEQFARDRSRFARRIAQAEEKLGPYLTPDSRARAWARLRNPSLPQSEPRSSSEATPLTQDVTTPSPLPSETPSPSLYLGGRRG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAPSPRPQHVL ----CCCCCCCCCEE	24.81	22006019
227	Phosphorylation	NKADPSNSPSSGSHS CCCCCCCCCCCCCCH	30.42	23684622
239	Phosphorylation	SHSRAWEYYSREKPK CCHHHHHHHCCCCCC	8.95	-
368	Phosphorylation	AFLKAWVYRPGEDTE HHHHHHCCCCCCCCH	10.61	-
406	Phosphorylation	AFLKAWVYRPGEDTE HHHHHHCCCCCCCCH	10.61	-
505	Phosphorylation	PLFQVAFYLPGEKPE CCEEEEEECCCCCCC	11.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PR15A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PR15A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PR15A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KIF3A_MOUSE	Kif3a	physical	10631107

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.