| UniProt ID | TNKS1_MOUSE | |
|---|---|---|
| UniProt AC | Q6PFX9 | |
| Protein Name | Tankyrase-1 | |
| Gene Name | Tnks | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1320 | |
| Subcellular Localization |
Cytoplasm. Golgi apparatus membrane Peripheral membrane protein. Chromosome, centromere. Nucleus, nuclear pore complex. Chromosome, telomere . Cytoplasm, cytoskeleton, spindle pole. Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicl |
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| Protein Description | Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity (By similarity).. | |
| Protein Sequence | MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGPTPASPTAGGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGAVCTVAAPAAVPAASAAVGVAPTPAGGGGGGGNNSASSASSPTSSSSSSPSSPGSSLAESPEAAGVGSTATLGAGAAGLGPGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDSLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPMRTSDVDYRLLEASKAGDLETVKQLCSPQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLTDLAVGGASNAGDGAAGAERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQKT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 320 | Ubiquitination | DLADPSAKAVLTGEY HHCCCCCCHHHCCCC | 43.28 | - | |
| 500 | Ubiquitination | ADLAKVKKTLALEII HCHHHHHHHHHHEEE | 52.32 | 22790023 | |
| 501 | Phosphorylation | DLAKVKKTLALEIIN CHHHHHHHHHHEEEC | 16.14 | 25619855 | |
| 576 | Ubiquitination | VLHKHGAKMNALDSL HHHHCCHHHHHHHHH | 36.96 | - | |
| 764 | Ubiquitination | EICKLLLKHGADPTK HHHHHHHHCCCCCCC | 39.71 | 27667366 | |
| 770 | Phosphorylation | LKHGADPTKKNRDGN HHCCCCCCCCCCCCC | 56.02 | - | |
| 784 | Ubiquitination | NTPLDLVKEGDTDIQ CCCHHHHHCCCCCHH | 64.38 | - | |
| 805 | Ubiquitination | AALLDAAKKGCLARV HHHHHHHHHCHHHHH | 51.96 | - | |
| 806 | Ubiquitination | ALLDAAKKGCLARVQ HHHHHHHHCHHHHHH | 50.56 | - | |
| 1013 | Ubiquitination | GAAGAERKEGEVAGL CCCCCCCCCCCCCCC | 62.67 | - | |
| 1029 | Ubiquitination | MNISQFLKSLGLEHL CCHHHHHHHCCHHHH | 44.94 | - | |
| 1196 | Phosphorylation | GFDERHAYIGGMFGA CCCHHCCCCCCHHCC | 8.25 | - | |
| 1257 | Phosphorylation | GKSFLQFSTMKMAHA CCCHHHHHHCHHCCC | 18.03 | 23140645 | |
| 1258 | Phosphorylation | KSFLQFSTMKMAHAP CCHHHHHHCHHCCCC | 23.31 | 23140645 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TNKS1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TNKS1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TNKS1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KIF3A_MOUSE | Kif3a | physical | 22473005 | |
| GMDS_HUMAN | GMDS | physical | 26496610 | |
| NUMA1_HUMAN | NUMA1 | physical | 26496610 | |
| PSMD2_HUMAN | PSMD2 | physical | 26496610 | |
| SDC2_HUMAN | SDC2 | physical | 26496610 | |
| HERC2_HUMAN | HERC2 | physical | 26496610 | |
| 3BP5_HUMAN | SH3BP5 | physical | 26496610 | |
| SSA27_HUMAN | SSSCA1 | physical | 26496610 | |
| ABRX2_HUMAN | FAM175B | physical | 26496610 | |
| PKCB1_HUMAN | ZMYND8 | physical | 26496610 | |
| ATP5S_HUMAN | ATP5S | physical | 26496610 | |
| S39AA_HUMAN | SLC39A10 | physical | 26496610 | |
| ZN687_HUMAN | ZNF687 | physical | 26496610 | |
| RM24_HUMAN | MRPL24 | physical | 26496610 | |
| TNKS2_HUMAN | TNKS2 | physical | 26496610 | |
| SLX4_HUMAN | SLX4 | physical | 26496610 | |
| TB182_HUMAN | TNKS1BP1 | physical | 26496610 | |
| SBSN_HUMAN | SBSN | physical | 26496610 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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