KCNJ1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNJ1_MOUSE
• UniProt AC: O88335
• Protein Name: ATP-sensitive inward rectifier potassium channel 1
• Gene Name: Kcnj1
• Organism: Mus musculus (Mouse).
• Sequence Length: 372
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane..
• Protein Description: In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium (By similarity)..
• Protein Sequence: MFKHLRRWFVTHIFGRSRQRARLVSKDGRCNIEFGNVDAQSRFIFFVDIWTTVLDLKWRYKMTVFITAFLGSWFLFGLLWYVVAYVHKDLPEFYPPDNRTPCVENINGMTSAFLFSLETQVTIGYGFRFVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTITPEGETIILDQTNINFVVDAGNENLFFISPLTIYHIIDHNSPFFHMAAETLSQQDFELVVFLDGTVESTSATCQVRTSYIPEEVLWGYRFVPIVSKTKEGKYRVDFHNFGKTVEVETPHCAMCLYNEKDARARMKRGYDNPNFVLSEVDETDDTQM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	RQRARLVSKDGRCNI HHHEEEECCCCCEEE		22817900
98	N-linked_Glycosylation	PEFYPPDNRTPCVEN CHHCCCCCCCCCCHH		-
182	Phosphorylation	FSKNAVISKRGGKLC ECCCEEECCCCCEEE		-
312	Ubiquitination	RFVPIVSKTKEGKYR EEEEEEECCCCCEEE		-
344	Ubiquitination	AMCLYNEKDARARMK EEEECCHHHHHHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
25	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
25	S	Phosphorylation	Kinase	SGK1	Q9WVC6	Uniprot
25	S	Phosphorylation	Kinase	SGK-FAMILY	-	GPS
25	S	Phosphorylation	Kinase	SGK_GROUP	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
25	S	Phosphorylation	Phosphorylation at Ser-25 by SGK1 is necessary for its expression at the cell membrane.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNJ1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KCNJ1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.