DLGP5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DLGP5_MOUSE
• UniProt AC: Q8K4R9
• Protein Name: Disks large-associated protein 5
• Gene Name: Dlgap5
• Organism: Mus musculus (Mouse).
• Sequence Length: 808
• Subcellular Localization: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells (By similarity)..
• Protein Description: Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells (By similarity)..
• Protein Sequence: MLVSRFASRFRKDSSTEMVRTNLAHRKSLSQKENRHRVYERNRHFGLKDVNIPLEGRELGNIHETSQDLSPEKASSKTRSVKMVLSDQRKQLLQKYKEEKQLQKLKEQREKAKRGVFKVGLYRPAAPGFLVTDQRGAKAEPEKAFPHTGRITRSKTKEYMEQTKIGSRNVPKATQSDQRQTSEKQPLDRERKVMQPVLFTSGKGTESAATQRAKLMARTVSSTTRKPVTRATNEKGSERMRPSGGRPAKKPEGKPDKVIPSKVERDEKHLDSQTRETSEMGPLGVFREVESLPATAPAQGKERKSFAPKHCVFQPPCGLKSYQVAPLSPRSANAFLTPNCDWNQLRPEVFSTTTQDKANEILVQQGLESLTDRSKEHVLNQKGASTSDSNHASVKGVPCSEGSEGQTSQPPHDVPYFRKILQSETDRLTSHCLEWEGKLDLDISDEAKGLIRTTVGQTRLLIKERFRQFEGLVDNCEYKRGEKETTCTDLDGFWDMVSFQVDDVNQKFNNLIKLEASGWKDSNNPSKKVLRKKIVPGRTSKAKQDDDGRAAARSRLAAIKNAMKGRPQQEVQAHAAAPETTKEVDKIVFDAGFFRIESPVKSFSVLSSERRSQRFGTPLSASKVVPEGRAAGDLLRQKMPLKKPDPQSSKSEHVDRTFSDGLESRCHVEDTPCPGEQDSSDIEHDVNKINVKMDCFSVETNLPLPAGDANTNQKEAISAVEGASTAVTSQDLLMSNPETNTSSQSNTSQEEAEASQSVLLHKSLTSECHLLEPPGLSCTSPCTREETRQPDRSRQFSFGGDLILFSPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	Phosphorylation	ELGNIHETSQDLSPE ECCCCCCCCCCCCHH	19.95	22942356
66	Phosphorylation	LGNIHETSQDLSPEK CCCCCCCCCCCCHHH	20.79	27566939
70	Phosphorylation	HETSQDLSPEKASSK CCCCCCCCHHHHCCC	39.02	27087446
75	Phosphorylation	DLSPEKASSKTRSVK CCCHHHHCCCCCHHH	43.36	25619855
76	Phosphorylation	LSPEKASSKTRSVKM CCHHHHCCCCCHHHH	42.79	25619855
80	Phosphorylation	KASSKTRSVKMVLSD HHCCCCCHHHHHHHH	31.18	-
156	Phosphorylation	GRITRSKTKEYMEQT CCCCHHHCHHHHHHH	30.29	25266776
167	Phosphorylation	MEQTKIGSRNVPKAT HHHHCCCCCCCCCCC	24.93	-
201	Phosphorylation	MQPVLFTSGKGTESA HCCEEECCCCCCHHH	31.04	-
219	Phosphorylation	RAKLMARTVSSTTRK HHHHHHHHCCCCCCC	18.40	14729942
224	Phosphorylation	ARTVSSTTRKPVTRA HHHCCCCCCCCCCCC	38.35	14729942
291	Phosphorylation	GVFREVESLPATAPA CHHEEEECCCCCCCC	44.84	-
321	Phosphorylation	QPPCGLKSYQVAPLS CCCCCCCEEEECCCC	26.32	26643407
322	Phosphorylation	PPCGLKSYQVAPLSP CCCCCCEEEECCCCC	12.86	26643407
328	Phosphorylation	SYQVAPLSPRSANAF EEEECCCCCCCCCCC	19.74	26824392
331	Phosphorylation	VAPLSPRSANAFLTP ECCCCCCCCCCCCCC	29.29	26643407
337	Phosphorylation	RSANAFLTPNCDWNQ CCCCCCCCCCCCHHH	13.15	26643407
386	Phosphorylation	LNQKGASTSDSNHAS HHCCCCCCCCCCCCE	35.70	-
598	Phosphorylation	AGFFRIESPVKSFSV CCCEEEECCCCEEEE	32.40	26239621
607	Phosphorylation	VKSFSVLSSERRSQR CCEEEECCCHHHHHH	28.18	-
612	Phosphorylation	VLSSERRSQRFGTPL ECCCHHHHHHCCCCC	31.74	24759943
617	Phosphorylation	RRSQRFGTPLSASKV HHHHHCCCCCCHHHC	20.53	21659605
620	Phosphorylation	QRFGTPLSASKVVPE HHCCCCCCHHHCCCC	31.53	21082442
622	Phosphorylation	FGTPLSASKVVPEGR CCCCCCHHHCCCCCH	23.70	28066266
657	Phosphorylation	KSEHVDRTFSDGLES CCCCCCHHHCCCCHH	24.03	25266776
659	Phosphorylation	EHVDRTFSDGLESRC CCCCHHHCCCCHHCC	30.10	22942356
671	Phosphorylation	SRCHVEDTPCPGEQD HCCCCCCCCCCCCCC	17.18	25619855
679	Phosphorylation	PCPGEQDSSDIEHDV CCCCCCCCHHCCCCH	29.60	27087446
680	Phosphorylation	CPGEQDSSDIEHDVN CCCCCCCHHCCCCHH	51.39	27087446
728	Phosphorylation	EGASTAVTSQDLLMS CCCCCCCCCHHHHHC	20.43	-
743	Phosphorylation	NPETNTSSQSNTSQE CCCCCCCCCCCCCHH	35.27	-
777	Phosphorylation	LLEPPGLSCTSPCTR CCCCCCCCCCCCCCC	22.67	25619855
779	Phosphorylation	EPPGLSCTSPCTREE CCCCCCCCCCCCCCC	32.12	25619855
780	Phosphorylation	PPGLSCTSPCTREET CCCCCCCCCCCCCCC	23.46	25619855
783	Phosphorylation	LSCTSPCTREETRQP CCCCCCCCCCCCCCC	44.49	25619855
797	Phosphorylation	PDRSRQFSFGGDLIL CCCCCCCCCCCCEEE	18.04	27600695
806	Phosphorylation	GGDLILFSPL----- CCCEEEEECC-----	23.11	26370283

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
328	S	Phosphorylation	Kinase	MAPK1	P63085	GPS
607	S	Phosphorylation	Kinase	AURKA	P97477	Uniprot
797	S	Phosphorylation	Kinase	AURKA	P97477	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DLGP5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DLGP5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DLGP5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-328, AND MASSSPECTROMETRY.
PubMed: 19131326

"Identification of phosphoproteins and their phosphorylation sites inthe WEHI-231 B lymphoma cell line.";
Shu H., Chen S., Bi Q., Mumby M., Brekken D.L.;
Mol. Cell. Proteomics 3:279-286(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-219 AND THR-224, ANDMASS SPECTROMETRY.
PubMed: 14729942