LRFN1_MOUSE - dbPTM
LRFN1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LRFN1_MOUSE
UniProt AC Q2WF71
Protein Name Leucine-rich repeat and fibronectin type III domain-containing protein 1
Gene Name Lrfn1
Organism Mus musculus (Mouse).
Sequence Length 766
Subcellular Localization Membrane
Single-pass type I membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Detected in excitatory, but not inhibitory, synaptic plasma membrane..
Protein Description Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1..
Protein Sequence MAPGPFSSGLFSPPPAALPFLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHLILGNNQIRKVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGGGPKPPTPLTVSFGGNPLHCNCELLWLRRLTREDDLETCATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPPPAAPPPLTEPGSSDIATPGRPGANDSTSERRLVAAELTSSSVLIRWPAQRPVPGIRMYQVQYNSSADDSLVYRMIPSTSQTFLVNDLAAGRAYDLCVLAVYDDGATALPATRVVGCVQFTTAGDPAPCRPLRAHFLGGTMIIAIGGVIVASVLVFIVLLMIRYKVYGDGDSRRIKGTSRTPPRVSHVCSQTNGAGAQQASAPPAPDRYEALREVAVPAAIEAKAMEAEATSTELEVVLGRSLGGSATSLCLLPSEETSGEESRAMTGPRRSRSGALGPPTSAPPTLALVPGGAPARPRPQQRYSFDGDYGALFQSHSYPRRARRTKRHRSTPHLDGAGGGAAGEDGDLGLGSARARLAFTSTEWMLESTV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
87N-linked_GlycosylationVRRRDFANMTSLVHL
HHHHHCCCCCCEEEE		33.97-
343N-linked_GlycosylationPDGRLLGNSSRTRVR
CCCCCCCCCCCCEEC		36.46-
434PhosphorylationRLVAAELTSSSVLIR
HHHHHHHHCCEEEEE		20.3321454597
574PhosphorylationSRRIKGTSRTPPRVS
CCCCCCCCCCCCCCC		42.7123737553
576PhosphorylationRIKGTSRTPPRVSHV
CCCCCCCCCCCCCCC		37.0923737553
637PhosphorylationLEVVLGRSLGGSATS
EEHHHCCCCCCCCEE		29.5723527152
641PhosphorylationLGRSLGGSATSLCLL
HCCCCCCCCEEEEEC		26.9525521595
643PhosphorylationRSLGGSATSLCLLPS
CCCCCCCEEEEECCC		24.7530372032
644PhosphorylationSLGGSATSLCLLPSE
CCCCCCEEEEECCCC		19.4619060867
662PhosphorylationGEESRAMTGPRRSRS
CHHHHHCCCCCCCCC		42.9524719451
667PhosphorylationAMTGPRRSRSGALGP
HCCCCCCCCCCCCCC		31.8829899451
669PhosphorylationTGPRRSRSGALGPPT
CCCCCCCCCCCCCCC		29.6622817900
676PhosphorylationSGALGPPTSAPPTLA
CCCCCCCCCCCCEEE		40.4329899451
677PhosphorylationGALGPPTSAPPTLAL
CCCCCCCCCCCEEEE		44.5520415495
681PhosphorylationPPTSAPPTLALVPGG
CCCCCCCEEEECCCC		24.4920415495
699PhosphorylationRPRPQQRYSFDGDYG
CCCCCCCCCCCCCHH		14.8929899451
700PhosphorylationPRPQQRYSFDGDYGA
CCCCCCCCCCCCHHH		21.0319060867
705PhosphorylationRYSFDGDYGALFQSH
CCCCCCCHHHHHCCC		15.1629899451
711PhosphorylationDYGALFQSHSYPRRA
CHHHHHCCCCCCCCC		13.6829899451
713PhosphorylationGALFQSHSYPRRARR
HHHHCCCCCCCCCCC		41.9222817900
714PhosphorylationALFQSHSYPRRARRT
HHHCCCCCCCCCCCC		8.7121082442
726PhosphorylationRRTKRHRSTPHLDGA
CCCCCCCCCCCCCCC		39.9225521595
727PhosphorylationRTKRHRSTPHLDGAG
CCCCCCCCCCCCCCC		18.0619060867
748PhosphorylationDGDLGLGSARARLAF
CCCCCCCCHHHEEEE		21.4429899451
756PhosphorylationARARLAFTSTEWMLE
HHHEEEEECHHHHHH		29.1829899451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LRFN1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LRFN1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LRFN1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of LRFN1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LRFN1_MOUSE

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Related Literatures of Post-Translational Modification

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