GRM3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRM3_MOUSE
• UniProt AC: Q9QYS2
• Protein Name: Metabotropic glutamate receptor 3
• Gene Name: Grm3
• Organism: Mus musculus (Mouse).
• Sequence Length: 879
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity..
• Protein Sequence: MKMLTRLQVLMLALFSKGFLVSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRYFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQICDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKGADSIVKFDTYGDGMGRYNVFNFQHIGGKYSYLKVGHWAETLYLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIRWEDAWAIGPVTIACLGFMCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
131	Phosphorylation	EYMCPDGSYAIQENI HHCCCCCCHHHHCCC	20.83	-
132	Phosphorylation	YMCPDGSYAIQENIP HCCCCCCHHHHCCCC	17.16	-
209	N-linked_Glycosylation	AEILRYFNWTYVSTV HHHHHHCCCEEEEEC	22.65	-
258	Phosphorylation	NIRKSYDSVIRELLQ HHHHHHHHHHHHHHC	15.94	-
292	N-linked_Glycosylation	IAAASRVNASFTWVA HHHHHEECEEEEEEE	28.85	-
414	N-linked_Glycosylation	MQRTLCPNTTKLCDA HHHHHCCCHHHHHHH	60.42	-
439	N-linked_Glycosylation	KDYLLKINFTAPFNP CEEEEEEEEECCCCC	26.99	-
877	Phosphorylation	EVLDSTTSSL----- HHHHCCCCCC-----	29.72	29899451
878	Phosphorylation	VLDSTTSSL------ HHHCCCCCC------	35.69	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRM3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRM3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRM3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GRM3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.