dbPTM

NETO1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NETO1_MOUSE
UniProt AC	Q8R4I7
Protein Name	Neuropilin and tolloid-like protein 1
Gene Name	Neto1
Organism	Mus musculus (Mouse).
Sequence Length	533
Subcellular Localization	Membrane Single-pass type I membrane protein . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Component of the postsynaptic density (PSD) of excitatory synapses.
Protein Description	Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory..
Protein Sequence	MIYGRSLFHIIASLIILHSSGATKKGTEKQITPETQKSVQCGTWTKHAEGGVFTSPNYPSKYPPDRECVYIIEAAPRQCIELYFDEKYSIEPSWECKFDHIEVRDGPFGFSPIIGRFCGQQNPPVIKSSGRFLWIKFFADGELESMGFSARYNFTPDPDFKDLGVLKPLPACEFEMGGPEGIVESIQILKEGKASASEAVDCKWYIRAPPRSKIYLRFLDYEMQNSNECKRNFVAVYDGSSSVEDLKAKFCSTVANDVMLRTGLGVIRMWADEGSRNSRFQMLFTSFQEPPCEGNTFFCHSNMCINNTLVCNGLQNCVYPWDENHCKEKRKTSLLDQLTNTSGTVIGVTSCIVIILIIVSVIVQIKQPRKKYVQRKSDFDQTVFQEVFEPPHYELCTLRGTGATADFADVAEDFENYHKLRRSSSKCIHDHHCGSQLSSAKGSRSNLSTRDASILAEIPTQPVKPLIPPVNRRNILVMKHNYSQDAADACDIDEIEEVPTTSHRLSRHEKSVQRFCLIGSLSKHESEYNTTRV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
128	Phosphorylation	QNPPVIKSSGRFLWI CCCCEEEECCCEEEE	27.22	-
306	N-linked_Glycosylation	CHSNMCINNTLVCNG ECCCEEECCEEEECC	30.42	-
340	N-linked_Glycosylation	SLLDQLTNTSGTVIG HHHHHHHCCCCCHHH	40.62	-
417	Phosphorylation	VAEDFENYHKLRRSS HHHHHHHHHHHHHCC	7.98	25521595
483	Phosphorylation	LVMKHNYSQDAADAC EEEECCCCCCHHHCC	27.23	25521595
520	Phosphorylation	QRFCLIGSLSKHESE HHHHHHHHHHCCHHH	23.60	22324799
522	Phosphorylation	FCLIGSLSKHESEYN HHHHHHHHCCHHHCC	33.39	22324799

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NETO1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NETO1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NETO1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NETO1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NETO1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain."; Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.; J. Proteome Res. 7:311-318(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-417, AND MASSSPECTROMETRY.	18034455 [Abstract]