KCNA1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNA1_MOUSE
• UniProt AC: P16388
• Protein Name: Potassium voltage-gated channel subfamily A member 1
• Gene Name: Kcna1
• Organism: Mus musculus (Mouse).
• Sequence Length: 495
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cell projection, axon . Membrane . Perikaryon . Cell projection, dendrite . Cell junction . Cell junction, synapse . Cytoplasmic vesicle . Endoplasmic reticulum . Cell junction, synapse, presynaptic cell membr
• Protein Description: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney. Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability. [PubMed: 9736643]
• Protein Sequence: MTVMSGENADEASTAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTIHRIDNTTVIYTSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTISKSEYMEIEEDMNNSIAHYRQANIRTGNCTTADQNCVNKSKLLTDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTVMSGENA ------CCCCCCCCC	25.56	-
5	Phosphorylation	---MTVMSGENADEA ---CCCCCCCCCCCC	38.32	19060867
13	Phosphorylation	GENADEASTAPGHPQ CCCCCCCCCCCCCCC	24.05	-
14	Phosphorylation	ENADEASTAPGHPQD CCCCCCCCCCCCCCC	43.87	-
23	Phosphorylation	PGHPQDGSYPRQADH CCCCCCCCCCCCCCC	40.01	22817900
24	Phosphorylation	GHPQDGSYPRQADHD CCCCCCCCCCCCCCC	14.15	20415495
53	Ubiquitination	LRFETQLKTLAQFPN CCHHHHHHHHHHCCC	31.51	22790023
54	Phosphorylation	RFETQLKTLAQFPNT CHHHHHHHHHHCCCC	35.60	-
67	Ubiquitination	NTLLGNPKKRMRYFD CCCCCCHHHCCCCCC	57.94	22790023
129	Ubiquitination	LGEEAMEKFREDEGF HHHHHHHHHHHCCCC	36.31	22790023
207	N-linked_Glycosylation	GTIHRIDNTTVIYTS CEEEEECCCEEEEEC	34.97	-
243	S-palmitoylation	LVVRFFACPSKTDFF HHHHHHCCCCCCHHH	3.10	-
322	Phosphorylation	LGQTLKASMRELGLL HHHHHHHHHHHHHHH	19.45	-
413	Phosphorylation	VIVSNFNYFYHRETE EEEECCCEEEECCCC	11.02	-
419	Phosphorylation	NYFYHRETEGEEQAQ CEEEECCCCCHHHHH	49.61	17114649
437	Phosphorylation	VSSPNLASDSDLSRR CCCCCCCCCCCCCCC	40.59	-
439	Phosphorylation	SPNLASDSDLSRRSS CCCCCCCCCCCCCCC	37.65	-
446	Phosphorylation	SDLSRRSSSTISKSE CCCCCCCCCCCCHHH	29.68	-
464	Phosphorylation	IEEDMNNSIAHYRQA HHHHHHHCHHHHHHC	19.02	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
322	S	Phosphorylation	Kinase	PKA	-	Uniprot
446	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
243	C	Palmitoylation	Palmitoylated on Cys-243; which may be required for membrane targeting.	-
446	S	Phosphorylation	Phosphorylation at Ser-446 regulates channel activity by down-regulating expression at the cell membrane (By similarity).	22158511

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNA1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCNA2_MOUSE	Kcna2	physical	18053989

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.