UB2V2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UB2V2_MOUSE
• UniProt AC: Q9D2M8
• Protein Name: Ubiquitin-conjugating enzyme E2 variant 2
• Gene Name: Ube2v2
• Organism: Mus musculus (Mouse).
• Sequence Length: 145
• Protein Description: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage..
• Protein Sequence: MAVSTGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGSKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVILQELRRLMMSKENMKLPQPPEGQTYNN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAVSTGVKV ------CCCCCCCCC	12.17	-
66	Acetylation	ENRIYSLKVECGSKY CCCEEEEEEECCCCC	30.01	22826441
66	Ubiquitination	ENRIYSLKVECGSKY CCCEEEEEEECCCCC	30.01	-
72	Acetylation	LKVECGSKYPEAPPS EEEECCCCCCCCCCC	50.54	22826441
72	Malonylation	LKVECGSKYPEAPPS EEEECCCCCCCCCCC	50.54	26320211
72	Ubiquitination	LKVECGSKYPEAPPS EEEECCCCCCCCCCC	50.54	-
85	Ubiquitination	PSVRFVTKINMNGIN CCEEEEEEEECCCCC	27.12	-
108	Ubiquitination	RSIPVLAKWQNSYSI CHHHHHECCCCCCHH	45.19	-
129	Ubiquitination	LRRLMMSKENMKLPQ HHHHHCCHHHCCCCC	34.90	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UB2V2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UB2V2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UB2V2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBE2N_MOUSE	Ube2n	physical	12039045
UBE2N_MOUSE	Ube2n	physical	11406273

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.