UBE2N_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBE2N_MOUSE
• UniProt AC: P61089
• Protein Name: Ubiquitin-conjugating enzyme E2 N
• Gene Name: Ube2n
• Organism: Mus musculus (Mouse).
• Sequence Length: 152
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. [PubMed: 22424771]
• Protein Sequence: MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Ubiquitination	GLPRRIIKETQRLLA CCCHHHHHHHHHHHC	52.95	-
10	Malonylation	GLPRRIIKETQRLLA CCCHHHHHHHHHHHC	52.95	26320211
10	Acetylation	GLPRRIIKETQRLLA CCCHHHHHHHHHHHC	52.95	22826441
24	Ubiquitination	AEPVPGIKAEPDESN CCCCCCCCCCCCCCC	53.24	-
24	Acetylation	AEPVPGIKAEPDESN CCCCCCCCCCCCCCC	53.24	23236377
68	Ubiquitination	EYPMAAPKVRFMTKI CCCCCCCCEEEEECC	41.12	-
74	Ubiquitination	PKVRFMTKIYHPNVD CCEEEEECCCCCCHH	29.49	-
74	Acetylation	PKVRFMTKIYHPNVD CCEEEEECCCCCCHH	29.49	23236377
82	Ubiquitination	IYHPNVDKLGRICLD CCCCCHHHHHHHHHH	48.86	-
82	Acetylation	IYHPNVDKLGRICLD CCCCCHHHHHHHHHH	48.86	23236377
82	Malonylation	IYHPNVDKLGRICLD CCCCCHHHHHHHHHH	48.86	26320211
87	S-nitrosocysteine	VDKLGRICLDILKDK HHHHHHHHHHHHCCC	2.42	-
87	Glutathionylation	VDKLGRICLDILKDK HHHHHHHHHHHHCCC	2.42	24333276
87	S-nitrosylation	VDKLGRICLDILKDK HHHHHHHHHHHHCCC	2.42	19101475
92	Ubiquitination	RICLDILKDKWSPAL HHHHHHHCCCCCHHH	58.56	-
94	Ubiquitination	CLDILKDKWSPALQI HHHHHCCCCCHHHHH	48.24	-
94	Acetylation	CLDILKDKWSPALQI HHHHHCCCCCHHHHH	48.24	23806337
94	Succinylation	CLDILKDKWSPALQI HHHHHCCCCCHHHHH	48.24	23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBE2N_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBE2N_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBE2N_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UB2V2_HUMAN	UBE2V2	physical	12039045
TNAP3_MOUSE	Tnfaip3	physical	20185725

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.