MYPR_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYPR_MOUSE
• UniProt AC: P60202
• Protein Name: Myelin proteolipid protein
• Gene Name: Plp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 277
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Myelin membrane . Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat.
• Protein Description: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin..
• Protein Sequence: MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTKF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	S-palmitoylation	--MGLLECCARCLVG --CCHHHHHHHHHCC	1.91	28680068
7	S-palmitoylation	-MGLLECCARCLVGA -CCHHHHHHHHHCCC	1.63	28680068
10	S-palmitoylation	LLECCARCLVGAPFA HHHHHHHHHCCCHHH	1.60	15923654
104	Phosphorylation	VRQIFGDYKTTICGK HHHHHCCCCEEEECC	15.60	25521595
105	Acetylation	RQIFGDYKTTICGKG HHHHCCCCEEEECCC	43.88	7969393
105	Ubiquitination	RQIFGDYKTTICGKG HHHHCCCCEEEECCC	43.88	22790023
107	Phosphorylation	IFGDYKTTICGKGLS HHCCCCEEEECCCEE	15.32	-
109	S-palmitoylation	GDYKTTICGKGLSAT CCCCEEEECCCEEEE	4.29	28680068
109	S-nitrosylation	GDYKTTICGKGLSAT CCCCEEEECCCEEEE	4.29	24895380
111	Ubiquitination	YKTTICGKGLSATVT CCEEEECCCEEEEEC	52.87	22790023
114	Phosphorylation	TICGKGLSATVTGGQ EEECCCEEEEECCCC	30.48	25521595
114	O-linked_Glycosylation	TICGKGLSATVTGGQ EEECCCEEEEECCCC	30.48	4042003
116	Phosphorylation	CGKGLSATVTGGQKG ECCCEEEEECCCCCC	18.41	25521595
118	Phosphorylation	KGLSATVTGGQKGRG CCEEEEECCCCCCCC	31.10	25521595
118	O-linked_Glycosylation	KGLSATVTGGQKGRG CCEEEEECCCCCCCC	31.10	29155983
122	Ubiquitination	ATVTGGQKGRGSRGQ EEECCCCCCCCCCCH	54.58	22790023
122	Acetylation	ATVTGGQKGRGSRGQ EEECCCCCCCCCCCH	54.58	155455
126	Phosphorylation	GGQKGRGSRGQHQAH CCCCCCCCCCHHHHH	31.70	29899451
134	Phosphorylation	RGQHQAHSLERVCHC CCHHHHHHHHHHHHH	34.63	22324799
139	S-palmitoylation	AHSLERVCHCLGKWL HHHHHHHHHHHHHHC	2.05	28680068
141	S-palmitoylation	SLERVCHCLGKWLGH HHHHHHHHHHHHCCC	4.54	28680068
193	Phosphorylation	SIAFPSKTSASIGSL HHCCCCCCCCCHHHH	33.59	19060867
194	Phosphorylation	IAFPSKTSASIGSLC HCCCCCCCCCHHHHH	24.61	20415495
196	Phosphorylation	FPSKTSASIGSLCAD CCCCCCCCHHHHHHH	27.52	25521595
199	O-palmitoylation	KTSASIGSLCADARM CCCCCHHHHHHHHHH	20.71	-
201	S-nitrosylation	SASIGSLCADARMYG CCCHHHHHHHHHHHC	3.27	24895380
207	Nitration	LCADARMYGVLPWNA HHHHHHHHCCCCCCC	9.87	-
218	Ubiquitination	PWNAFPGKVCGSNLL CCCCCCCCCCCCHHH	34.29	-
228	S-nitrosylation	GSNLLSICKTAEFQM CCHHHHHHCCCHHHH	2.62	24895380

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYPR_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYPR_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYPR_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MYPR_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.