dbPTM

SYNE1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SYNE1_MOUSE
UniProt AC	Q6ZWR6
Protein Name	Nesprin-1
Gene Name	Syne1
Organism	Mus musculus (Mouse).
Sequence Length	8799
Subcellular Localization	Nucleus outer membrane Single-pass type IV membrane protein Cytoplasmic side . Nucleus. Nucleus envelope. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere. The largest part of the protein is cytoplasmic, while its C-terminal part is assoc
Protein Description	Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 seem to act redundantly in cerebellum, midbrain, brain stem, and other brain regions except cerebral cortex and hippocampus. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenenis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette..
Protein Sequence	MATSRASSRSHRDITNVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGIKLLALLEVLSGQKLPCEQGHRVKRIHAVANIGTALKFLEGRKIKLVNINATDIADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSMVSTETASPPSKRKVAAKIQGNAKKTLLKWVQHTAGKQMGIEVKDFGKSWRTGLAFHSVIHAIQPELVDLEKVKTRSNRENLEDAFTIAETQLGIPRLLDPEDVDVDKPDEKSIMTYVAQFLTQYPDIHGAGCDGQEDDVVFVGFTNNIALLLGFQRDDRLILKETKVWIEQFERDFTRAQMTESSLQDKYQAFKHFRVQYEMKRKQVEHIIQPLQRDGKLTLDQALVKQCWERVSSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITIQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYQTRSVNGIPMPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVELLLQSYISFIENSKFFEQYEVTYQILKQTADIYVKAEGSVEEAENVMKFMSEATAQWRNLSVEVRSVRSMLEEVISNWDRYGDTVASLQAWLEDAEKMLSQSEHAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEIVSRDLKQQLLLLNGRWRELFMEVKQYARADEMDRMKKEYIDVTTTLFGFATEAHRKLSEPLEVSFINVKLLIQDLEDLEKRVPVMDAQYKMIAKKAHLFAKESPQEEANEMLTTMSKLKEQLSKVKECCSPLLYEAQQLTVPLEELETQITSFYDSLGKINEILSVLEQEAQSSTLFKQKHQELLASQENCKKSLTLIEKGSQSVQKLVTSSQARKPWDHTKLQKQIADVHHAFQSMIKKTGDWKKHVEANSRLMKKFEESRAELEKVLRVAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIAVEKDRFSAAVEECRAELEQETKLAPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCGKLPVQDPVRDTCGACHTALKELKASIDNTYTMLVDDPDKWKDYTSRFSEFSSWVSAKKACLKKIKDEPIDTGNHDEVKHMVDEIRNDITKKGESLSWLKSRLKYLIDISSENEAQKRGDELAELSSSFKALVALLSEVEKLLSNFGECVQYKEIVKSSLEGLISGPQESKEEAEMILDSKNLLEAQQLLLHHQQKTKMISAKKRDLQEQMEQAQQGGQAGPGQEELRKLESTLTGLEQSRERQERRIQVSLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIATQAENLVKEAAELPLGPRNKRVLQRQAKSIKEQVTTLEDTLEEDIKTMEMVKSKWDHFGSNFETLSIWILEKENELSSLEASASAADVQISQIKVTIQEIESKIDSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYWEELQEHARGLEGTILGHLSQQQKFEENLRKIRQSVSEFAERLADPIKICSSAAETYKVLQEHMDLCQAVESLSSTVTMFSASAQKAVNRESCTQEAAALQQQYEEILHKAKEMQTALEDLLARWQRLEKGLSPFLTWLERCEAIASSPEKDISADRGKVESELQLIQALQNEVVSQASLYSNLLQLKEALFSVASKEDVAVMKLQLEQLDERWGDLPQIISKRMHFLQSVLAEHKQFDELLFSFSVWIKQFLGELQRTSEINLRDHQVALTRHKDHAAEIEKKRGEITHLQGHLSQLRSLGRAQDLHPLQSKVDDCFQLFEEASQVVERRKLALAQLAEFLQSHACMSTLLYQLRQTVEATKSMSKKQSDSLKTDLHSAIQDVKTLESSAISLDGTLTKAQCHLKSASPEERTSCRATTDQLSLEVERIQNLLGTKQSEADALVALKEAFREQKEELLRSIEDIEERMDRERLKVPTRQALQHRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINGLEATWDDTRRQIHENQGQCCGLIDLVREYQSLKSTVCNVLEDASNVVVMRATIKDQGDLKWAFSKHETSRNEMNSKQKELDSFTSKGKHLLSELKKIHSGDFSLVKTDMESTLDKWLDVSERIEENMDMLRVSLSIWDDVLSRKDEIEGWSNSSLPKLAENISNLNNSLRAEELLKELESEVKIKALKLEDLHSKINNLKELTKNPETPTELQFIEADLRQKLEHAKEITEEARGTLKDFTAQRTQVERFVKDITAWLINVEESLTRCAQTETCEGLKKAKDIRKELQSQQNSITSTQEELNSLCRKHHSVELESLGRAMTGLIKKHEATSQLCSQTQARIQDSLEKHFSGSMKEFQEWFLGAKAAARESSNLTGDSQILEARLHNLQGVLDSLSDGQSKLDVVTQEGQTLYAHLPKQIVSSIQEQITKANEEFQAFLKQCLKEKQALQDCVSELGSFEDQHRKLNLWIHEMEERLKTENLGESKHHISEKKNEVRKVEMFLGELLAARESLDKLSQRGQLLSEESHSAGKGGCRSTQLLTSYQSLLRVTKEKLRSCQLALKEHEALEEATQSMWARVKDVQDRLACAESTLGNKETLEGRLSQIQDILLMKGEGEVKLNLAIGKGDQALRSSNKEGQQAIQDQLEMLKKAWAEAMNSAVHAQSTLESVIDQWNDYLEKKSQLEQWMESVDQRLEHPLQLQPGLKEKFSLLDHFQSIVSEAEDHTGALQQLAAKSRELYQKTQDESFKEAGQEELRTQFQDIMTVAKEKMRTVEDLVKDHLMYLDAVQEFADWLHSAKEELHRWSDTSGDPSATQKKLLKIKELIDSREIGAGRLSRVESLAPAVKQNTAASGCELLNSEMQALRADWRQWEDCLFQTQSSLESLVSEMALSEQEFFGQVTQLEQALEQFCTLLKTWAQQLTLLEGKNSDEEILECWHKGREILDALQKAEPMTEDLKSQLNELCRFSRDLSPYSEKVSGLIKEYNCLCLQASKGCQNKEQILQERFQKASRGFQQWLVNAKITTAKCFDLPQNLSEVSSSLQKIQEFLSESENGQHKLNTMLFKGELLSSLLTEEKAQAVQAKVLTAKEEWKSFHANLHQKESALENLKIQMKDFEVSAELVQNWLSKTERLVQESSNRLYDLPAKRREQQKLQSVLEEIQCYEPQLHRLKEKARQLWEGQAASKSFVHRVSQLSSQYLALSNVTKEKVSRLDRIIAEHNRFSQGVKELQDWMSDAVHMLDSYCLPTSDKSVLDSRMLKLEALLSVRQEKEIQMKMVVTRGEYVLQSTSLEGSAAVQQQLQAVKDMWESLLSAAIRCKSQLEGALSKWTSYQDDVRQFSSWMDSVEVSLTESEKQHTELREKITALGKAKLLNEEVLSHSSLLETIEVKRAAMTEHYVTQLELQDLQERHQALKEKAKEAVTKLEKLVRLHQEYQRDLKAFESWLEQEQEKLDRCSVHEGDTNAHETMLRDLQELQVRCAEGQALLNSVLHTREDVIPSGLPQAEDRVLESLRQDWQVYQHRLAEARMQLNNVVNKLRLMEQKFQQADEWLKRMEEKINFRSECQSSRSDKEIQLLQLKKWHEDLSAHRDEVEEVGTRAQGILDETHISSRMGCQATQLTSRYQALLLQVLEQIKFFEEELQCLEETESSLSSYSDWYGSTHKNFKNVATKIDKVDESMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAMKFLAEHEAEALRKEIHTYMEQLKNLTSTVRKECMSLEKGLHLAKEFSDKYKVLAQWMAEYQEILCTPEEPKMELYEKKAQLSKYKSLQQMVLSHEPSVTSVQEKSEALLELVQDQSLKDKIQKLQSDFQDLCSRAKERVFSLEAKVKDHEDYNTELQEVEKWLLQMSGRLVAPDLLEMSSLETITQQLAHHKAMMEEIAGFEDRLDNLKAKGDTLIGQCPEHLQAKQKQTVQAHLQGTKDSYSAICSTAQRVYRSLEYELQKHVSSQDTLQQCQAWISAVQPDLKPSPQPPLSRAEAVKQVKHFRALQEQARTYLDLLCSMCDLSNSSVKNTAKDIQQTEQLIEQRLVQAQNLTQGWEEIKSLKAELWIYLQDADQQLQNMKRRHTELEINIAQNMVMQVKDFIKQLQCKQVSVSTIVEKVDKLTKNQESPEHKEITHLNDQWQDLCLQSDKLCAQREQDLQRTSSYHDHMRVVEAFLEKFTTEWDSLARSNAESTAIHLEALKKLALALQEEMYAIDDLKDCKQKLIEQLGLDDRELVREQTSHLEQRWFQLQDLVKRKIQVSVTNLEELNVIQSRFQELMEWAEEQQPNIVEALKQSPPPGMAQHLLMDHLAICSELEAKQVLLKSLMKDADRVMADLGLNERKVIQKALSEAQKHVSCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIVFREYICLLPDDVSKQVKTCKTAQASLKTYQNEVTGLCAQGRELMKGITKQEQEEVLGKLQELQTVYDTVLQKCSHRLQELEKSLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNEKTELHAQLDKYQSILEQSPEYENLLLTLQTTGQAMLPSLNEVDHSYLSEKLSALPQQFNVIVALAKDKFYKTQEAILARKEYTSLIELTTQSLGDLEDQFLKMRKMPSDLIVEESVSLQQSCSALLGEVVALGEAVNELNQKKESFRSTGQPWQPEKMLQLATLYHRLKRQAEQRVSFLEDTTSVYKEHAQMCRQLESQLEVVKREQAKVNEETLPAEEKLKVYHSLAGSLQDSGILLKRVATHLEDLSPHLDPTAYEKAKSQVQSWQEELKQMTSDVGELVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVCLDLSLQDIQEEIRKIQIHQEEVLSSLRIMSALSHKEQEKFTKAKELISADLEHTLAELQELDGDVQEALRTRQATLTEIYSRCQRYYQVFQAANDWLDDAQEMLQLAGNGLDVESAEENLRSHMEFFKTEGQFHSNMEELRGLVARLDPLIKATGKEELAQKMASLEKRSQGIIQESHTQRDLLQRCMVQWQEYQKAREGVIELMNDAEKKLSEFAVLKTSSIHEAEEKLSKHKALVSVVDSFHEKIVALEEKASQLEQTGNDTSKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWKRLSAKVKETTEVINQLQGRLPGSSTEKASKAELMTLLESHDTYLMDLESQQLTLGVLQQRALSMLQDRAFPGTEEEVPILRAITALQDQCLNMQEKVKNHGKLVKQELQEREAVETRINSVKSWVQETKDYLGNPTIEIDTQLEELKRLLAEATSHQESIEKIAEEQKNKYLGLYTVLPSEISLQLAEVALDLKIHDQIQEKVQEIEEGKAMSQEFSCKIQKVTKDLTTILTKLKAKTDDLVHAKAEHKMLGEELDGCNSKLMELDAAIQTFSERHSQLGQPLAKKIGKLTELHQQTIRQAENRLSKLNQALSHMEEYNEMLETVRKWIEKAKVLVHGNIAWNSASQLQEQYILHQTLLEESGEIDSDLEAMAEKVQHLANVYCTGKLSQQVTQFGREMEELRQAIRVRLRNLQDAAKDMKKFEGELRNLQVALEQAQTILTSPEVGRRSLKEQLCHRQHLLSEMESLKPKMQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASQLQHTAIQQCNIMQAKKHSLIFPPKEAVVQYEQYKQEMKHLQQLIEEAHREIEDKPVATSNIQELQAQISLHEELAQKIKGYQEQIDSLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDRELHPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTEAAVNQDIAYYQALSAEGLQTDAARIPPSAAVSQELYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEVLERQQKYQDSLQSISTKMEAMEMKLGESLEPSRSPESQMAEHQALMDEVQMLQDEINGLQVSLAEELVAESQESDPAEQLALQSTLTVLAERMSTIRMKAAGKRQLLEEKLSDQLEEQRQEQALQRYRCEADELDHWLLNTKATLDVALGTSQEPMDMDAQLVDCQNMLVEIEQKVVALSQLSVHNENLLLEGKAHTKEEAEQLAVKLRLLKGSLGELQRALHDRQLDMQGVTQEKEENDVDFTDTQSPGVQEWLAQARTTRTHQRQSSLQQQKEFEQELAEQKSLLRSVASRGEEILTQHSTAEGSGGLGEKPDVLSQELGIAEDQMRVKWESLHQEFSAKQKLLQNILEQEQEQVLYSSPNRLLSGVLPFRGEAQTQDKTSVTSLLDGLSQAFGEASSQSGGTDRQSIHLEQKLYDGVSATSTWLNDVEERLFVATAPLPEETEACLFNQEALAKDIKEMSEEMDKNKNLFSQAFPEDSDNRDVIEDTLGCLLGRLSLLDSVVDQRCHQMKERLQQILRFQNDLKVLFTSLADSKYIILQKLANVFEQPIVEQMQAIQQAEEGLRDLEGGISELKRWADKLQVEQSAVQELSKLQDMYDELLMTVSSRRSSLHQNLALKSQYDKALQDLVDLLDTGQEKMTGDQKIIVCSKEEIQQLLGKHKEYFQGLESHMILTEILFRKIVGFAAVKETQFHTDCMAQASAVLKQAHKRGVELEYILEMWSHLDENRQELSRQLEVIENSIPSVGLVEESEDRLVERTNLYQHLKSSLNEYQPKLYQALDDGKRLLMSVSCSELESQLNQLGEHWLSNTNKVSKELHRLETILKHWTRYQSEAAALNHWLQCAKDRLAFWTQQSVTVPQELEMVRDHLSAFLEFSKEVDAKSALKSSVTSTGNQLLRLKKVDTAALRAELSRMDSQWTDLLTGIPVVQEKLHQLQMDKLPSRHAISEVMSWISLMESVILKDEEDIRNAIGYKAIHEYLQKYKGFKIDLNCKQLTADFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQLLQGRVGEKIQMLEGLLESWSEYENSVQSLKAWFANQERKLKEQHLLGDRNSVENALKDCQELEDLIKAKEKEVEKIEQNGLALIQNKREEVSGSVMSTLQELRQTWISLDRTVEQLKIQLTSALGQWSNHKAACDEINGHLMEARYSLSRFRLLTGSSEAVQVQVDNLQNLHDELEKQEGGLQKFGSITNQLLKECHPPVAETLSSTLQEVNMRWNNLLEEIAEQLHSSKALLQLWQRYKDYSKQCASAIQRQEEQTSVLLKAATNKDIADDEVTKWIQDCNDLLKGLETVKDSLFILRELGEQLGQQVDVSAAAAIQCEQLCFSQRLGALEQALCKQQAVLQAGVVDYETFAKSLEALEVWMVEAEGILQGQDPTHSSDLSTIQERMEELKGQMLKFSSLAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLTSSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEHKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIVDGQNLLEQGQVDDREEFSLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLAEVSHLPLSGLGNIPVPLQQVRMLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELTDIQEKWKAASMHLEEQKKKLAFLLKDWEKCERGIANSLEKLRMFKKRLSQPLPDHHEELHAEQMRCKELENAVGRWTDDLTELMLVRDALAVYLSAEDISMLKERVELLQRQWEELCHQVSLRRQQVSERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAVAQENKIQLQEMGERLAKASHESKASEIQYKLSRVKDRWQHLLDLMAARVKKLKETLVAVQQLDKNMGSLRTWLAHMESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLEVSERTAAFPSSSGVLYTVAKEELKKFEAFQRQVHESLTQLELINKQYRRLARENRTDSACSLRQMVHGGNQRWDDLQKRVTSILRRLKHFISQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAVIEEELDELRRYCQEVFGRVERYHKKLIRLPVRLPDDHDLSDRELDLEDSTALSDLRWQDPSADGMPSPQPSSNPSLSLPQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESASRTLPSEDEEGEEDKEFYLRGAVGLSGDPSSLESQMRQLDKALDDSRFQIQQTANILRSKTPTGPDLDTSYKGYMKLLGECSGSIDSVRRLEHKLAEEESFPGFVNLNSTETQTAGVIDRWELLQAQAMSKELRMKQNLQKWQQFNSDLNNIWAWLGETEEELDRLQHLALSTDIHTIESHIKKLKELQKAVDHRKAIILSINLCSSEFTQADSKESHDLQDRLSQMNGRWDRVCSLLEDWRGLLQDALMQCQEFHEMSHALLLMLENIDRRKNEIVPIDSTLDPETLQDHHKQLMQIKQELLKSQLRVASLQDMSRQLLVNAEGSDCLEAKEKVHVIGNRLKLLLKEVSHHIKDLEKLLDMSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKSPRGKCSLSQPGPSVSSPKSRSTRDGSDSSRSDPRPERVGRAFLFRILRAALPFQLLLLLLIGLTCLVPMSEKDYSCALSNNFARSFHPMLRYTNGPPPL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MATSRASSRS -----CCCCCCCCCC	30.52	21183079
8	Phosphorylation	MATSRASSRSHRDIT CCCCCCCCCCHHHHH	36.50	21183079
206	Phosphorylation	EVKDFGKSWRTGLAF EEHHCCHHHHHHHHH	23.36	-
377 (in isoform 2)	Phosphorylation	-	42.46	25521595
377 (in isoform 3)	Phosphorylation	-	42.46	25521595
386 (in isoform 2)	Phosphorylation	-	40.36	26643407
386 (in isoform 3)	Phosphorylation	-	40.36	26643407
387 (in isoform 2)	Phosphorylation	-	30.03	26643407
387 (in isoform 3)	Phosphorylation	-	30.03	26643407
390 (in isoform 2)	Phosphorylation	-	51.32	29899451
390 (in isoform 3)	Phosphorylation	-	51.32	29899451
438	Phosphorylation	IQQVHEETANTIQRK HHHHHHHHHHHHHHH	23.40	26487105
451	Phosphorylation	RKLEQHKDLLQNTDA HHHHHCHHHHHCCHH	50.95	24719451
500 (in isoform 2)	Phosphorylation	-	5.73	30635358
501 (in isoform 2)	Phosphorylation	-	2.43	30635358
505 (in isoform 2)	Phosphorylation	-	6.01	30635358
506 (in isoform 2)	Phosphorylation	-	4.86	27742792
509 (in isoform 2)	Phosphorylation	-	20.96	30635358
606	Phosphorylation	VEVRSVRSMLEEVIS HHHHHHHHHHHHHHH	26.09	-
710	Acetylation	ADEMDRMKKEYIDVT HHHHHHHHHHHHHHH	43.26	7617723
732	Phosphorylation	TEAHRKLSEPLEVSF HHHHHHCCCCCEEEE	39.96	21183079
847	Phosphorylation	VLEQEAQSSTLFKQK HHHHHHHHCHHHHHH	32.13	29899451
848	Phosphorylation	LEQEAQSSTLFKQKH HHHHHHHCHHHHHHH	19.63	20415495
849	Phosphorylation	EQEAQSSTLFKQKHQ HHHHHHCHHHHHHHH	41.27	20415495
881	Ubiquitination	KGSQSVQKLVTSSQA HHCHHHHHHHHHCCC	42.65	-
1186	Phosphorylation	ESLSWLKSRLKYLID CCHHHHHHHHHHHHH	40.45	22982522
1255	Phosphorylation	LISGPQESKEEAEMI HHCCCCCCHHHHHHH	39.87	-
1315	Phosphorylation	GQEELRKLESTLTGL CHHHHHHHHHHHHHH	5.20	24719451
1318	Phosphorylation	ELRKLESTLTGLEQS HHHHHHHHHHHHHHH	20.97	24719451
1357	Phosphorylation	VVRYLFQTGSSHERF HHHHHHHCCCCCHHC	31.53	22324799
1359	Phosphorylation	RYLFQTGSSHERFLS HHHHHCCCCCHHCCC	31.73	19060867
1360	Phosphorylation	YLFQTGSSHERFLSF HHHHCCCCCHHCCCH	30.61	22324799
1366	Phosphorylation	SSHERFLSFSSLESL CCCHHCCCHHHHHHH	21.99	20415495
1368	Phosphorylation	HERFLSFSSLESLSS CHHCCCHHHHHHHHH	30.55	29899451
1369	Phosphorylation	ERFLSFSSLESLSSE HHCCCHHHHHHHHHH	33.86	20415495
1372	Phosphorylation	LSFSSLESLSSELEQ CCHHHHHHHHHHHHH	38.55	20415495
1374	Phosphorylation	FSSLESLSSELEQTK HHHHHHHHHHHHHHH	30.92	29899451
1375	Phosphorylation	SSLESLSSELEQTKE HHHHHHHHHHHHHHH	52.04	20415495
1380	Phosphorylation	LSSELEQTKEFSKRT HHHHHHHHHHHHHHH	24.14	20415495
1389	Phosphorylation	EFSKRTESIATQAEN HHHHHHHHHHHHHHH	19.53	29899451
1410 (in isoform 5)	Phosphorylation	-	39.35	29899451
1420	Phosphorylation	VLQRQAKSIKEQVTT HHHHHHHHHHHHHCC	41.74	29899451
2268	Phosphorylation	ELTKNPETPTELQFI HHHCCCCCCHHHHHH	36.45	24925903
2270	Phosphorylation	TKNPETPTELQFIEA HCCCCCCHHHHHHHH	57.66	24925903
2519	Phosphorylation	VSELGSFEDQHRKLN HHHHCCCHHHHHHHH	59.46	24719451
2572	Phosphorylation	LLAARESLDKLSQRG HHHHHHHHHHHHHHH	6.04	24719451
2663	Phosphorylation	ETLEGRLSQIQDILL HHHHHHHHHHHHHHH	24.71	22802335
2877	Malonylation	DPSATQKKLLKIKEL CCCHHHHHHHHHHHH	49.59	26073543
2880	Malonylation	ATQKKLLKIKELIDS HHHHHHHHHHHHHHH	63.27	26073543
2900	Phosphorylation	GRLSRVESLAPAVKQ CHHHHHHHHHHHHHH	27.29	22807455
3014	Phosphorylation	LQKAEPMTEDLKSQL HHHHCCCCHHHHHHH	36.74	22802335
3154	Phosphorylation	TAKEEWKSFHANLHQ CHHHHHHHHHCHHHH	24.28	-
4186	Phosphorylation	QLQCKQVSVSTIVEK HHCCCCCCHHHHHHH	14.09	21454597
4188	Phosphorylation	QCKQVSVSTIVEKVD CCCCCCHHHHHHHHH	12.62	21454597
4189	Phosphorylation	CKQVSVSTIVEKVDK CCCCCHHHHHHHHHH	27.21	21454597
4198	Phosphorylation	VEKVDKLTKNQESPE HHHHHHHCCCCCCCC	33.42	21454597
4401	Phosphorylation	AKQVLLKSLMKDADR HHHHHHHHHHCHHHH	33.40	-
4479	Phosphorylation	RKIVFREYICLLPDD HHHHHHEHHHHCCCC	7.83	28059163
4934	Phosphorylation	IHQEEVLSSLRIMSA CCHHHHHHHHHHHHH	32.28	25159016
4935	Phosphorylation	HQEEVLSSLRIMSAL CHHHHHHHHHHHHHC	19.94	25159016
5178	Phosphorylation	GNDTSKATLSRSMTT CCCCCHHHHCHHHHH	29.06	22871156
5184	Phosphorylation	ATLSRSMTTVWQRWT HHHCHHHHHHHHHHH	21.31	22871156
5185	Phosphorylation	TLSRSMTTVWQRWTR HHCHHHHHHHHHHHH	15.88	22871156
5191	Phosphorylation	TTVWQRWTRLRAVAQ HHHHHHHHHHHHHHH	23.24	28059163
5425	Phosphorylation	IEEGKAMSQEFSCKI HHHHCCCCHHHHHHH	31.27	22802335
5436	Phosphorylation	SCKIQKVTKDLTTIL HHHHHHHHHCHHHHH	26.35	22802335
5651	Phosphorylation	VALEQAQTILTSPEV HHHHHHHHHHHCHHH	22.44	25777480
5654	Phosphorylation	EQAQTILTSPEVGRR HHHHHHHHCHHHHHH	38.08	25777480
5655	Phosphorylation	QAQTILTSPEVGRRS HHHHHHHCHHHHHHH	18.67	21183079
5864	Phosphorylation	MTAGRCHTLLSPVTE EECCCCCEEECCCCC	32.78	30635358
5867	Phosphorylation	GRCHTLLSPVTEESG CCCCEEECCCCCCCC	22.04	30635358
5870	Phosphorylation	HTLLSPVTEESGEEG CEEECCCCCCCCCCC	37.10	30635358
5873	Phosphorylation	LSPVTEESGEEGTNS ECCCCCCCCCCCCCC	45.32	30635358
5878	Phosphorylation	EESGEEGTNSEISSP CCCCCCCCCCCCCCC	38.56	30635358
5880	Phosphorylation	SGEEGTNSEISSPPA CCCCCCCCCCCCCCC	35.82	30635358
5883	Phosphorylation	EGTNSEISSPPACRS CCCCCCCCCCCCCCC	32.51	30635358
5884	Phosphorylation	GTNSEISSPPACRSP CCCCCCCCCCCCCCC	40.33	20415495
5890	Phosphorylation	SSPPACRSPSPVANT CCCCCCCCCCCCCCC	29.61	21659605
5892	Phosphorylation	PPACRSPSPVANTEA CCCCCCCCCCCCCHH	33.00	21659605
5897	Phosphorylation	SPSPVANTEAAVNQD CCCCCCCCHHHHCCC	19.77	26643407
5907	Phosphorylation	AVNQDIAYYQALSAE HHCCCHHHHHHHCCC	9.10	26643407
5952	Phosphorylation	KLGDLQRSWETLKNV HHHHHHHHHHHHHHH	19.12	26824392
5955	Phosphorylation	DLQRSWETLKNVISE HHHHHHHHHHHHHHH	36.45	23984901
5983	Phosphorylation	KYQDSLQSISTKMEA HHHHHHHHHHHHHHH	24.65	-
5985	Phosphorylation	QDSLQSISTKMEAME HHHHHHHHHHHHHHH	27.50	-
5986	Phosphorylation	DSLQSISTKMEAMEM HHHHHHHHHHHHHHH	32.51	-
6238	Phosphorylation	TRTHQRQSSLQQQKE HHHHHHHHHHHHHHH	34.89	30635358
6239	Phosphorylation	RTHQRQSSLQQQKEF HHHHHHHHHHHHHHH	23.12	26026062
6331	Phosphorylation	QEQVLYSSPNRLLSG HHHHHHCCCCCHHCC	16.79	29899451
6583	Phosphorylation	TVSSRRSSLHQNLAL HHHHHCHHHHHHHHH	28.23	29899451
6801	Phosphorylation	ETILKHWTRYQSEAA HHHHHHHHHHHHHHH	21.15	22802335
6803	Phosphorylation	ILKHWTRYQSEAAAL HHHHHHHHHHHHHHH	14.71	22802335
6864	Phosphorylation	ALKSSVTSTGNQLLR HHHHHHCCHHHHHHH	31.96	28576409
8024	Phosphorylation	WLEVSERTAAFPSSS HHHHHHHHHCCCCCC	20.49	26643407
8029	Phosphorylation	ERTAAFPSSSGVLYT HHHHCCCCCCCCCHH	30.59	26643407
8030	Phosphorylation	RTAAFPSSSGVLYTV HHHCCCCCCCCCHHH	31.20	26643407
8031	Phosphorylation	TAAFPSSSGVLYTVA HHCCCCCCCCCHHHC	36.94	26643407
8035	Phosphorylation	PSSSGVLYTVAKEEL CCCCCCCHHHCHHHH	9.21	26643407
8036	Phosphorylation	SSSGVLYTVAKEELK CCCCCCHHHCHHHHH	15.15	26643407
8225 (in isoform 4)	Phosphorylation	-	55.66	25521595
8227	Phosphorylation	LPDDHDLSDRELDLE CCCCCCCCCCCCCCC	40.45	27742792
8234 (in isoform 4)	Phosphorylation	-	49.97	26643407
8235 (in isoform 4)	Phosphorylation	-	59.59	26643407
8236	Phosphorylation	RELDLEDSTALSDLR CCCCCCCCCCHHCCC	13.25	21183079
8238 (in isoform 4)	Phosphorylation	-	14.71	29899451
8240	Phosphorylation	LEDSTALSDLRWQDP CCCCCCHHCCCCCCC	31.94	23737553
8248	Phosphorylation	DLRWQDPSADGMPSP CCCCCCCCCCCCCCC	47.48	20415495
8254	Phosphorylation	PSADGMPSPQPSSNP CCCCCCCCCCCCCCC	27.55	19060867
8258	Phosphorylation	GMPSPQPSSNPSLSL CCCCCCCCCCCCCCC	37.18	19060867
8259	Phosphorylation	MPSPQPSSNPSLSLP CCCCCCCCCCCCCCC	60.49	20415495
8262	Phosphorylation	PQPSSNPSLSLPQPL CCCCCCCCCCCCCCC	34.54	20415495
8264	Phosphorylation	PSSNPSLSLPQPLRS CCCCCCCCCCCCCCC	42.20	20415495
8274	Phosphorylation	QPLRSERSGRDTPAS CCCCCCCCCCCCCCC	33.84	29899451
8278	Phosphorylation	SERSGRDTPASVDSI CCCCCCCCCCCCCCC	21.28	21659605
8281	Phosphorylation	SGRDTPASVDSIPLE CCCCCCCCCCCCCCC	27.88	21082442
8284	Phosphorylation	DTPASVDSIPLEWDH CCCCCCCCCCCCCCC	24.77	21082442
8293	Phosphorylation	PLEWDHDYDLSRDLE CCCCCCCCCCCCCHH	18.50	30635358
8296	Phosphorylation	WDHDYDLSRDLESAS CCCCCCCCCCHHHHH	22.35	30635358
8301	Phosphorylation	DLSRDLESASRTLPS CCCCCHHHHHCCCCC	38.55	29899451
8303	Phosphorylation	SRDLESASRTLPSED CCCHHHHHCCCCCCC	34.77	25338131
8305	Phosphorylation	DLESASRTLPSEDEE CHHHHHCCCCCCCCC	40.29	25521595
8308	Phosphorylation	SASRTLPSEDEEGEE HHHCCCCCCCCCCCC	61.87	25521595
8328	Phosphorylation	LRGAVGLSGDPSSLE HHHHHCCCCCHHHHH	34.91	29899451
8332	Phosphorylation	VGLSGDPSSLESQMR HCCCCCHHHHHHHHH	52.90	29899451
8333	Phosphorylation	GLSGDPSSLESQMRQ CCCCCHHHHHHHHHH	41.36	29899451
8336	Phosphorylation	GDPSSLESQMRQLDK CCHHHHHHHHHHHHH	34.27	29899451
8361	Phosphorylation	QTANILRSKTPTGPD HHHHHHHCCCCCCCC	37.12	25619855
8363	Phosphorylation	ANILRSKTPTGPDLD HHHHHCCCCCCCCCC	27.59	26824392
8365	Phosphorylation	ILRSKTPTGPDLDTS HHHCCCCCCCCCCCC	67.58	25619855
8384	Phosphorylation	MKLLGECSGSIDSVR HHHHHHCCCCHHHHH	31.13	28066266
8386	Phosphorylation	LLGECSGSIDSVRRL HHHHCCCCHHHHHHH	13.61	28066266
8389	Phosphorylation	ECSGSIDSVRRLEHK HCCCCHHHHHHHHHH	18.82	28066266
8613	Phosphorylation	KSQLRVASLQDMSRQ HHHHHHHHHHHHHHH	24.57	29176673
8675	Phosphorylation	QQDLSSWSSADELDT CCCHHHCCCCCCCCC	20.00	25338131
8706	Phosphorylation	KSPRGKCSLSQPGPS CCCCCCCCCCCCCCC	34.24	29472430
8708	Phosphorylation	PRGKCSLSQPGPSVS CCCCCCCCCCCCCCC	20.31	29472430

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
732	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
1366	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
1389	S	Phosphorylation	Kinase	PRKACA	P17612	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SYNE1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SYNE1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SUN1_MOUSE	Sun1	physical	16079285

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SYNE1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8227, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8308, AND MASSSPECTROMETRY.	16452087 [Abstract]