UniProt ID | ABI1_MOUSE | |
---|---|---|
UniProt AC | Q8CBW3 | |
Protein Name | Abl interactor 1 | |
Gene Name | Abi1 {ECO:0000312|MGI:MGI:104913} | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 481 | |
Subcellular Localization | Cytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, growth cone. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cytoplasm, cytoskeleton. Localized to protruding lamellipodia and | |
Protein Description | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.. | |
Protein Sequence | MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQKPPSPPVSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTAGPAAPGAAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVAAQFSAQPHVNGGPLYSQNSISVAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYSDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFKEGAIIYVIKKNDDGWFEGVCNRVTGLFPGNYVESIMHYTD | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
2 | Acetylation | ------MAELQMLLE ------CHHHHHHHH | 26.63 | - | |
23 | Phosphorylation | KRALIESYQNLTRVA HHHHHHHHHHHHHHH | 6.66 | 22817900 | |
53 | Phosphorylation | ALEETKAYTTQSLAS HHHHHHHHCHHHHHH | 16.33 | - | |
88 | Phosphorylation | SQLRRMESSINHISQ HHHHHHHHHHHHHHH | 27.46 | 54231201 | |
89 | Phosphorylation | QLRRMESSINHISQT HHHHHHHHHHHHHHH | 17.69 | 28059163 | |
143 (in isoform 5) | Phosphorylation | - | 10.24 | 29514104 | |
143 (in isoform 4) | Phosphorylation | - | 10.24 | 29514104 | |
143 | Phosphorylation | YIRKPIDYTVLDDVG HCCCCCCEEEECCCC | 10.24 | 29514104 | |
143 (in isoform 2) | Phosphorylation | - | 10.24 | 29514104 | |
143 (in isoform 3) | Phosphorylation | - | 10.24 | 29514104 | |
154 | Ubiquitination | DDVGHGVKWLKAKHG CCCCCHHHHHHHCCC | 51.94 | - | |
154 (in isoform 2) | Ubiquitination | - | 51.94 | - | |
165 (in isoform 3) | Phosphorylation | - | 26.32 | 29514104 | |
165 (in isoform 2) | Phosphorylation | - | 26.32 | 29514104 | |
165 (in isoform 5) | Phosphorylation | - | 26.32 | 29514104 | |
165 (in isoform 4) | Phosphorylation | - | 26.32 | 29514104 | |
170 | Phosphorylation | NQPARTGTLSRTNPP CCCCCCCCCCCCCCC | 22.43 | 46157091 | |
172 | Phosphorylation | PARTGTLSRTNPPTQ CCCCCCCCCCCCCCC | 36.58 | 67380211 | |
174 | Phosphorylation | RTGTLSRTNPPTQKP CCCCCCCCCCCCCCC | 49.02 | 24925903 | |
178 | Phosphorylation | LSRTNPPTQKPPSPP CCCCCCCCCCCCCCC | 50.94 | 24925903 | |
178 (in isoform 4) | Phosphorylation | - | 50.94 | 19144319 | |
183 | Phosphorylation | PPTQKPPSPPVSGRG CCCCCCCCCCCCCCC | 50.81 | 24925903 | |
187 | Phosphorylation | KPPSPPVSGRGTLGR CCCCCCCCCCCCCCC | 28.66 | 25521595 | |
191 | Phosphorylation | PPVSGRGTLGRNTPY CCCCCCCCCCCCCCC | 25.36 | 25266776 | |
196 | Phosphorylation | RGTLGRNTPYKTLEP CCCCCCCCCCCCCCC | 27.00 | 26824392 | |
198 | Phosphorylation | TLGRNTPYKTLEPVK CCCCCCCCCCCCCCC | 17.99 | 20116462 | |
199 | Ubiquitination | LGRNTPYKTLEPVKP CCCCCCCCCCCCCCC | 48.08 | - | |
200 | Phosphorylation | GRNTPYKTLEPVKPP CCCCCCCCCCCCCCC | 30.43 | 23527152 | |
205 | Ubiquitination | YKTLEPVKPPTVPND CCCCCCCCCCCCCCC | 56.87 | - | |
208 | Phosphorylation | LEPVKPPTVPNDYMT CCCCCCCCCCCCCCC | 58.06 | 22499769 | |
213 | Phosphorylation | PPTVPNDYMTSPARL CCCCCCCCCCCCHHC | 14.66 | 18515860 | |
215 | Phosphorylation | TVPNDYMTSPARLGS CCCCCCCCCCHHCCC | 25.90 | 22942356 | |
216 | Phosphorylation | VPNDYMTSPARLGSQ CCCCCCCCCHHCCCC | 10.47 | 23527152 | |
217 (in isoform 4) | Phosphorylation | - | 16.54 | 19144319 | |
222 | Phosphorylation | TSPARLGSQHSPGRT CCCHHCCCCCCCCCC | 29.34 | 25521595 | |
225 | Phosphorylation | ARLGSQHSPGRTASL HHCCCCCCCCCCCCC | 22.78 | 27087446 | |
229 | Phosphorylation | SQHSPGRTASLNQRP CCCCCCCCCCCCCCC | 26.89 | 28542873 | |
231 | Phosphorylation | HSPGRTASLNQRPRT CCCCCCCCCCCCCCC | 27.52 | 26824392 | |
233 (in isoform 4) | Phosphorylation | - | 33.06 | 23984901 | |
233 (in isoform 2) | Phosphorylation | - | 33.06 | 23984901 | |
235 (in isoform 2) | Phosphorylation | - | 22.92 | 23984901 | |
235 (in isoform 4) | Phosphorylation | - | 22.92 | 23984901 | |
237 (in isoform 4) | Phosphorylation | - | 47.46 | 23984901 | |
237 (in isoform 2) | Phosphorylation | - | 47.46 | 23984901 | |
238 (in isoform 4) | Phosphorylation | - | 24.07 | 23984901 | |
238 (in isoform 2) | Phosphorylation | - | 24.07 | 23984901 | |
240 | Phosphorylation | NQRPRTHSGSSGGSG CCCCCCCCCCCCCCC | 39.49 | 21183079 | |
241 (in isoform 4) | Phosphorylation | - | 20.44 | 23984901 | |
241 (in isoform 2) | Phosphorylation | - | 20.44 | 23984901 | |
242 | Phosphorylation | RPRTHSGSSGGSGSR CCCCCCCCCCCCCCC | 28.91 | 21183079 | |
243 (in isoform 4) | Phosphorylation | - | 51.18 | 23984901 | |
243 | Phosphorylation | PRTHSGSSGGSGSRE CCCCCCCCCCCCCCC | 51.18 | 19367708 | |
243 (in isoform 2) | Phosphorylation | - | 51.18 | 23984901 | |
247 (in isoform 4) | Phosphorylation | - | 33.72 | 23984901 | |
247 (in isoform 2) | Phosphorylation | - | 33.72 | 23984901 | |
248 | Phosphorylation | GSSGGSGSRENSGSS CCCCCCCCCCCCCCC | 37.81 | 21183079 | |
249 (in isoform 4) | Phosphorylation | - | 51.12 | 23984901 | |
249 (in isoform 2) | Phosphorylation | - | 51.12 | 23984901 | |
250 (in isoform 4) | Phosphorylation | - | 58.40 | 23984901 | |
250 (in isoform 2) | Phosphorylation | - | 58.40 | 23984901 | |
251 (in isoform 4) | Phosphorylation | - | 51.03 | 23984901 | |
251 (in isoform 2) | Phosphorylation | - | 51.03 | 23984901 | |
252 | Phosphorylation | GSGSRENSGSSSIGI CCCCCCCCCCCCCCC | 34.99 | 21183079 | |
254 | Phosphorylation | GSRENSGSSSIGIPI CCCCCCCCCCCCCEE | 22.26 | 21183079 | |
255 | Phosphorylation | SRENSGSSSIGIPIA CCCCCCCCCCCCEEE | 29.51 | 25777480 | |
256 | Phosphorylation | RENSGSSSIGIPIAV CCCCCCCCCCCEEEE | 26.91 | 25777480 | |
260 (in isoform 4) | Phosphorylation | - | 11.85 | - | |
260 (in isoform 2) | Phosphorylation | - | 11.85 | - | |
265 | Phosphorylation | GIPIAVPTPSPPTAG CCEEEECCCCCCCCC | 29.78 | 25777480 | |
265 (in isoform 4) | Phosphorylation | - | 29.78 | - | |
265 (in isoform 2) | Phosphorylation | - | 29.78 | - | |
267 | Phosphorylation | PIAVPTPSPPTAGPA EEEECCCCCCCCCCC | 46.09 | 25777480 | |
270 | Phosphorylation | VPTPSPPTAGPAAPG ECCCCCCCCCCCCCC | 47.86 | 25777480 | |
282 | Phosphorylation | APGAAPGSQYGTMTR CCCCCCCCCCCCCCE | 21.12 | 25777480 | |
284 | Phosphorylation | GAAPGSQYGTMTRQI CCCCCCCCCCCCEEH | 19.09 | 25777480 | |
286 | Phosphorylation | APGSQYGTMTRQISR CCCCCCCCCCEEHCC | 15.50 | 25777480 | |
288 | Phosphorylation | GSQYGTMTRQISRHN CCCCCCCCEEHCCCC | 21.18 | 25777480 | |
292 | Phosphorylation | GTMTRQISRHNSTTS CCCCEEHCCCCCCCC | 21.10 | 2497921 | |
296 | Phosphorylation | RQISRHNSTTSSTSS EEHCCCCCCCCCCCC | 27.26 | 27087446 | |
297 | Phosphorylation | QISRHNSTTSSTSSG EHCCCCCCCCCCCCC | 35.69 | 30387612 | |
298 | Phosphorylation | ISRHNSTTSSTSSGG HCCCCCCCCCCCCCC | 22.09 | 24899341 | |
299 | Phosphorylation | SRHNSTTSSTSSGGY CCCCCCCCCCCCCCC | 31.54 | 27087446 | |
300 | Phosphorylation | RHNSTTSSTSSGGYR CCCCCCCCCCCCCCC | 30.16 | 30814537 | |
301 | Phosphorylation | HNSTTSSTSSGGYRR CCCCCCCCCCCCCCC | 27.03 | 23684622 | |
302 | Phosphorylation | NSTTSSTSSGGYRRT CCCCCCCCCCCCCCC | 29.00 | 29899451 | |
303 | Phosphorylation | STTSSTSSGGYRRTP CCCCCCCCCCCCCCH | 36.00 | 23984901 | |
306 | Phosphorylation | SSTSSGGYRRTPSVA CCCCCCCCCCCHHHH | 10.63 | 23684622 | |
404 | Phosphorylation | EEAAVVQYSDPYADG CCEEEEEECCCCCCC | 11.93 | 12316903 | |
428 | Phosphorylation | IEKVVAIYDYTKDKD HCEEEEEEEECCCCC | 7.99 | 25521595 | |
430 | Phosphorylation | KVVAIYDYTKDKDDE EEEEEEEECCCCCCC | 9.94 | 22817900 | |
431 | Phosphorylation | VVAIYDYTKDKDDEL EEEEEEECCCCCCCC | 29.84 | 22817900 | |
439 | Phosphorylation | KDKDDELSFKEGAII CCCCCCCCCCCCEEE | 32.02 | 18779572 | |
475 | Phosphorylation | FPGNYVESIMHYTD- CCCCHHHHHHCCCC- | 18.37 | 25619855 | |
479 | Phosphorylation | YVESIMHYTD----- HHHHHHCCCC----- | 8.67 | 25619855 | |
480 | Phosphorylation | VESIMHYTD------ HHHHHCCCC------ | 22.13 | 25619855 |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ABI1_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ABI1_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
BRK1_MOUSE | Brk1 | physical | 20697350 | |
WASF2_MOUSE | Wasf2 | physical | 20697350 | |
CYFP2_MOUSE | Cyfip2 | physical | 20697350 | |
P85A_MOUSE | Pik3r1 | physical | 12515821 | |
RASH_MOUSE | Hras | genetic | 12515821 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183 AND TYR-213, ANDMASS SPECTROMETRY. | |
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183 AND SER-222, ANDMASS SPECTROMETRY. | |
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183 AND SER-222, ANDMASS SPECTROMETRY. | |
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183, AND MASSSPECTROMETRY. | |
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain."; Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.; J. Proteome Res. 7:311-318(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-428, AND MASSSPECTROMETRY. |