CYFP2_MOUSE - dbPTM
CYFP2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CYFP2_MOUSE
UniProt AC Q5SQX6
Protein Name Cytoplasmic FMR1-interacting protein 2
Gene Name Cyfip2 {ECO:0000312|MGI:MGI:1924134}
Organism Mus musculus (Mouse).
Sequence Length 1253
Subcellular Localization Cytoplasm . Nucleus . Cytoplasm, perinuclear region . Cell junction, synapse, synaptosome . Highly expressed in the perinuclear region and enriched in synaptosomes (PubMed:11438699).
Protein Description Part of the WAVE1 complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). Involved in T-cell adhesion and p53-dependent induction of apoptosis (By similarity). Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. [PubMed: 27605705]
Protein Sequence MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGHDYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLADIVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFKQLQVVPLFGDMQIELARYIKTSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFISELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTDKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKGGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQLLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKIVKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTNGVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTVEHVRCFQPPIHQSLATTC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
97UbiquitinationSRAIPQVKCNEQPNR
CCCCCCCCCCCCCCC		26.5422790023
108PhosphorylationQPNRVEIYEKTVEVL
CCCCEEEEEHHHHHH		9.6222817900
120PhosphorylationEVLEPEVTKLMKFMY
HHHCHHHHHHHHHHH		19.4628059163
197UbiquitinationRAAQFLRKMADPQSI
HHHHHHHHHCCHHHH		40.3622790023
294AcetylationKKRINLSKIDKFFKQ
HHCCCHHHHHHHHHH		59.0822902405
322PhosphorylationLARYIKTSAHYEENK
HHHHHHHHHCCCCCC		14.19-
334S-palmitoylationENKSKWTCTQSSISP
CCCCCCEEECCCCCC		2.9528680068
366PhosphorylationFISELARYSNSEVVT
HHHHHHHHCCCCEEC		13.44-
367PhosphorylationISELARYSNSEVVTG
HHHHHHHCCCCEECC		28.46-
375PhosphorylationNSEVVTGSGLDSQKS
CCCEECCCCCCCCCC		27.1527841257
419PhosphorylationSWKLVHPTDKFCNKD
HEEEECCCCCCCCCC		36.62-
508PhosphorylationKKKNVLISVLQAIRK
HHCHHHHHHHHHHHH		16.7722817900
545UbiquitinationPKGGFDIKVPRRAVG
CCCCCCCCCCCCCCC		48.2922790023
559PhosphorylationGPSSTQLYMVRTMLE
CCCHHHHHHHHHHHH		5.4629514104
578PhosphorylationDKSGSKKTLRSSLDG
CCCCCCHHHHHHCCC		31.0120469934
581PhosphorylationGSKKTLRSSLDGPIV
CCCHHHHHHCCCCEE		38.0629899451
582PhosphorylationSKKTLRSSLDGPIVL
CCHHHHHHCCCCEEE		24.8519060867
733PhosphorylationFRAECKNYGVIIPYP
HHHHHHCCCEEEECC		9.7726160508
739PhosphorylationNYGVIIPYPPSNRYE
CCCEEEECCCCHHHH		19.8426160508
742PhosphorylationVIIPYPPSNRYETLL
EEEECCCCHHHHHHH		29.4526160508
745PhosphorylationPYPPSNRYETLLKQR
ECCCCHHHHHHHHHH		19.9526160508
747PhosphorylationPPSNRYETLLKQRHV
CCCHHHHHHHHHHHH		28.5826160508
750UbiquitinationNRYETLLKQRHVQLL
HHHHHHHHHHHHHHH		48.6922790023
777UbiquitinationRISAAMYKSLDQAIS
HHHHHHHHCHHHHHH		31.3022790023
934AcetylationVVMEELLKIVKSLLQ
HHHHHHHHHHHHHHH		59.067624025
966PhosphorylationCRLPRHEYGSPGILE
HCCCCHHHCCCCHHH		19.4425367039
968PhosphorylationLPRHEYGSPGILEFF
CCCHHHCCCCHHHHH		21.0325367039
1037AcetylationILPRVYIKEGERLEV
CCCEEEEECCCCCHH		41.81-
1037UbiquitinationILPRVYIKEGERLEV
CCCEEEEECCCCCHH		41.8122790023
1052UbiquitinationRMKRLEAKYAPLHLV
HHHHHHHHCCCHHHH		32.3522790023
1053PhosphorylationMKRLEAKYAPLHLVP
HHHHHHHCCCHHHHH		22.0925195567
1067PhosphorylationPLIERLGTPQQIAIA
HHHHHHCCHHHHHHH		23.6326824392
1196AcetylationDGKDEIIKNVPLKKM
CCCCHHHHCCCHHHH		58.5123236377
1209UbiquitinationKMADRIRKYQILNNE
HHHHHHHHHHHHCHH		38.8522790023
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CYFP2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CYFP2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CYFP2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ABI2_MOUSEAbi2physical
28671696
DP13A_MOUSEAppl1physical
28671696
KCC2A_MOUSECamk2aphysical
28671696
KCC2B_MOUSECamk2bphysical
28671696
CSKI1_MOUSECaskin1physical
28671696
CAD10_MOUSECdh10physical
28671696
CADH2_MOUSECdh2physical
28671696
CNTP1_MOUSECntnap1physical
28671696
CTNB1_MOUSECtnnb1physical
28671696
CTTB2_MOUSECttnbp2physical
28671696
DYN1_MOUSEDnm1physical
28671696
FYCO1_MOUSEFyco1physical
28671696
AINX_MOUSEInaphysical
28671696
KCMA1_MOUSEKcnma1physical
28671696
M3K5_MOUSEMap3k5physical
28671696
MYCB2_MOUSEMycbp2physical
28671696
MYO5A_MOUSEMyo5aphysical
28671696
NCKP1_MOUSENckap1physical
28671696
NEK9_MOUSENek9physical
28671696
NHSL2_MOUSENhsl2physical
28671696
PEX5R_MOUSEPex5lphysical
28671696
SKT_MOUSEEtl4physical
28671696
SPTB2_MOUSESptbn1physical
28671696
SRGP3_MOUSESrgap3physical
28671696
TNIK_MOUSETnikphysical
28671696
TPP2_MOUSETpp2physical
28671696
WASF1_MOUSEWasf1physical
28671696
ABI1_MOUSEAbi1physical
28671696
AP2A1_MOUSEAp2a1physical
28671696
CYFP1_MOUSECyfip1physical
28671696
DLG4_MOUSEDlg4physical
28671696
NLGN3_MOUSENlgn3physical
28671696
SHAN1_MOUSEShank1physical
28671696
SHAN3_MOUSEShank3physical
28671696
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CYFP2_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-108, AND MASSSPECTROMETRY.

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