SHAN1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SHAN1_MOUSE
• UniProt AC: D3YZU1
• Protein Name: SH3 and multiple ankyrin repeat domains protein 1
• Gene Name: Shank1
• Organism: Mus musculus (Mouse).
• Sequence Length: 2167
• Subcellular Localization: Cytoplasm. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Colocalizes with alpha-latrotoxin receptor 1..
• Protein Description: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function (By similarity)..
• Protein Sequence: MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPQGTRGRGSGAPGNLASTRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRFNPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGLKKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLGGSPNYKDRRGLTPLFHTAMVGGDPRCCELLLYNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKETCARILLYRGANKDVKNNNGQTPFQVAVIAGNFELGELIRNHREQDVVPFQESPKYAARRRGPPGAGLTVPPALLRANSDTSMALPDWMVFSAPGASSSGTPGPTSGSQGQSQPSAPSTKLSSGTLRSASSPRGARARSPSRGRHPEDAKRQPRGRPSSSGTPRDGPAGGTGGSGGPGGSLGSRGRRRKLYSAVPGRSFMAVKSYQAQGEGEISLSKGEKIKVLSIGEGGFWEGQVKGRVGWFPSDCLEEVANRSQEGRQESRSDKAKRLFRHYTVGSYDSFDAPSLIDGIDSGSDYIIKEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDEAVHKKASQQAKRLPPPAISLRSKSMTSELEEMVSPWKKKIEYEQQPAAVPSMEKKRTVYQMALNKLDEILAAAQQTISASESPGPGGLASLGKHRPKGFFATESSFDPHHRSQPSYDRPSFLPPGPGLMLRQKSIGAAEDDRPYLAPPAMKFSRSLSVPGSEDIPPPPTTSPPEPPYSTPPAPSSSGRLTPSPRGGPFNPGSGGPLPASSPSSFDGPSPPDPRSGGREKSLYHSGALPPAHHHPPHHHHHHAPPPQPHHHHAHPPHPPEMETGGSPDDPPPRLALGPQPSLRGWRGGGPSPTSGAPSPSHHSSSGGSSGPAQAPALRYFQLPPRAASAAMYVPARSGRGRKGPLVKQTKVEGEPQKGSLPPASSPTSPALPRSEPPPAGPSEKNSIPIPTIIIKAPSTSSSGRSSQGSSTEAEPPTQPDGAGGGGSSPSPAPATSPVPPSPSPVPTPASPSGPATLDFTSQFGAALVGAARREGGWQNEARRRSTLFLSTDAGDEDGGDSGLGPGAPPGPRLRHSKSIDEGMFSAEPYLRLESGGSSGGYGAYAAGSRAYGGSGSSSAFTSFLPPRPLVHPLTGKALDPASPLGLALAARERALKESSEGGVTPQPPPRPPSPRYDAPPPTLHHHSPHSPHSPHARHEPVLRLWGDPARRELGYRAGLGSQEKALTASPPAARRSLLHRLPPTAPGVGPLLLQLGPEPPTPHPGVSKAWRTAAPEEPERLPLHVRFLENCQARPPPAGTRGSSTEDGPGVPPPSPRRVLPTSPTSPRGNEENGLPLLVLPPPAPSVDVDDGEFLFAEPLPPPLEFSNSFEKPESPLTPGPPHPLPDPPSPATPLPAAPPPAVAAAPPTLDSTASSLTSYDSEVATLTQGAPAAPGDPPAPGPPAPAAPAPPAPQPGPDPPPGTDSGIEEVDSRSSSDHPLETISSASTLSSLSAEGGGNTGGVAGGGAGVASGTELLDTYVAYLDGQAFGGSGTPGPPYPPQLMTPSKLRGRALGTSGNLRPGPSGGLRDPVTPTSPTVSVTGAGTDGLLALSACSGPSTAGVAGGPVAVEPEVPPVPLPTASSLPRKLLPWEEGPGPPPPPLPGPLSQPQASALATVKASIISELSSKLQQFGGASTAGGALPWARGGSGGSTDSHHGGASYIPERTSSLQRQRLSEDSQTSLLSKPSSSIFQNWPKPPLPPLPTGSGVSSSTAAAPGATSPSASSASASTRHLQGVEFEMRPPLLRRAPSPSLLPASDHKVSPAPRPSSLPILPSGPLYPGLFDIRSSPTGGAGGSADPFAPVFVPPHPGISGGLGGALSGASRSLSPTRLLSLPPDKPFGAKPLGFWTKFDVADWLEWLGLSEHRAQFLDHEIDGSHLPALTKEDYVDLGVTRVGHRMNIDRALKFFLER

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTHSPATSE ------CCCCCCCCH	42.22	27708245
4	Phosphorylation	----MTHSPATSEDE ----CCCCCCCCHHH	24.54	27708245
7	Phosphorylation	-MTHSPATSEDEERH -CCCCCCCCHHHHHH	35.71	20415495
8	Phosphorylation	MTHSPATSEDEERHS CCCCCCCCHHHHHHC	45.19	20415495
24	Phosphorylation	SECPEGGSESDSSPD HCCCCCCCCCCCCCC	44.79	20415495
26	Phosphorylation	CPEGGSESDSSPDGP CCCCCCCCCCCCCCC	44.48	20415495
28	Phosphorylation	EGGSESDSSPDGPGR CCCCCCCCCCCCCCC	53.72	20415495
29	Phosphorylation	GGSESDSSPDGPGRG CCCCCCCCCCCCCCC	31.81	20415495
40	Phosphorylation	PGRGPQGTRGRGSGA CCCCCCCCCCCCCCC	25.38	-
43	Methylation	GPQGTRGRGSGAPGN CCCCCCCCCCCCCCC	32.58	24129315
45	Phosphorylation	QGTRGRGSGAPGNLA CCCCCCCCCCCCCCC	30.35	-
53	Phosphorylation	GAPGNLASTRGLQGR CCCCCCCCCCCCCCC	23.08	29899451
61	Phosphorylation	TRGLQGRSMSVPDDA CCCCCCCCCCCCCHH	23.41	18388127
63	Phosphorylation	GLQGRSMSVPDDAHF CCCCCCCCCCCHHHH	31.57	18388127
176	Phosphorylation	KQLAKLHTKTGLKKF HHHHHHHHHHHHHHH	40.51	20415495
178	Phosphorylation	LAKLHTKTGLKKFLE HHHHHHHHHHHHHHH	49.23	20415495
186	Phosphorylation	GLKKFLEYVQLGTSD HHHHHHHHHHHCCHH	8.81	29899451
413	Phosphorylation	DVVPFQESPKYAARR CCCCCCCCHHHHHHH	18.86	25521595
416	Phosphorylation	PFQESPKYAARRRGP CCCCCHHHHHHHHCC	14.63	-
439	Phosphorylation	PALLRANSDTSMALP HHHHHCCCCCCCCCC	41.08	29899451
499	Phosphorylation	PRGARARSPSRGRHP CCCCCCCCCCCCCCH	26.66	29899451
501	Phosphorylation	GARARSPSRGRHPED CCCCCCCCCCCCHHH	48.92	29899451
518	Phosphorylation	RQPRGRPSSSGTPRD CCCCCCCCCCCCCCC	35.46	29899451
519	Phosphorylation	QPRGRPSSSGTPRDG CCCCCCCCCCCCCCC	35.15	27708245
522	Phosphorylation	GRPSSSGTPRDGPAG CCCCCCCCCCCCCCC	19.66	29899451
531	Phosphorylation	RDGPAGGTGGSGGPG CCCCCCCCCCCCCCC	37.13	29899451
540	Phosphorylation	GSGGPGGSLGSRGRR CCCCCCCCCCCHHCH	35.16	22324799
543	Phosphorylation	GPGGSLGSRGRRRKL CCCCCCCCHHCHHHC	36.53	22324799
544	Methylation	PGGSLGSRGRRRKLY CCCCCCCHHCHHHCE	40.62	24129315
551	Phosphorylation	RGRRRKLYSAVPGRS HHCHHHCEECCCCCC	9.53	22324799
552	Phosphorylation	GRRRKLYSAVPGRSF HCHHHCEECCCCCCE	32.97	22324799
558	Phosphorylation	YSAVPGRSFMAVKSY EECCCCCCEEEEEEE	25.86	25521595
565	Phosphorylation	SFMAVKSYQAQGEGE CEEEEEEEECCCCCE	11.36	25177544
574	Phosphorylation	AQGEGEISLSKGEKI CCCCCEEECCCCCEE	23.45	21659605
615	Phosphorylation	LEEVANRSQEGRQES HHHHHHHCHHHHHHH	32.18	22817900
634	Phosphorylation	AKRLFRHYTVGSYDS HHHHHHHHCCCCCCC	10.00	22817900
635	Phosphorylation	KRLFRHYTVGSYDSF HHHHHHHCCCCCCCC	16.56	19060867
638	Phosphorylation	FRHYTVGSYDSFDAP HHHHCCCCCCCCCCC	22.79	19060867
639	Phosphorylation	RHYTVGSYDSFDAPS HHHCCCCCCCCCCCH	15.07	19060867
641	Phosphorylation	YTVGSYDSFDAPSLI HCCCCCCCCCCCHHC	19.45	29899451
646	Phosphorylation	YDSFDAPSLIDGIDS CCCCCCCHHCCCCCC	39.41	22807455
671	Phosphorylation	VLLQKKDSEGFGFVL EEEEECCCCCCCEEE	48.80	22817900
783	Phosphorylation	RLPPPAISLRSKSMT HCCCCCEECCCCHHH	21.60	22817900
786	Phosphorylation	PPAISLRSKSMTSEL CCCEECCCCHHHHHH	34.08	21082442
788	Phosphorylation	AISLRSKSMTSELEE CEECCCCHHHHHHHH	28.65	22817900
790	Phosphorylation	SLRSKSMTSELEEMV ECCCCHHHHHHHHHH	26.58	22807455
791	Phosphorylation	LRSKSMTSELEEMVS CCCCHHHHHHHHHHC	31.38	22817900
846	Phosphorylation	QTISASESPGPGGLA HHHHCCCCCCCCCCH	32.44	29899451
854	Phosphorylation	PGPGGLASLGKHRPK CCCCCCHHCCCCCCC	42.57	29899451
866	Phosphorylation	RPKGFFATESSFDPH CCCCCEECCCCCCCC	31.10	22324799
868	Phosphorylation	KGFFATESSFDPHHR CCCEECCCCCCCCCC	31.76	22324799
869	Phosphorylation	GFFATESSFDPHHRS CCEECCCCCCCCCCC	27.69	22324799
879	Phosphorylation	PHHRSQPSYDRPSFL CCCCCCCCCCCCCCC	31.84	22817900
898	Phosphorylation	GLMLRQKSIGAAEDD CCEECCCCCCCCCCC	20.23	25521595
908	Phosphorylation	AAEDDRPYLAPPAMK CCCCCCCCCCCCCCC	19.18	25521595
921	Phosphorylation	MKFSRSLSVPGSEDI CCCCCCCCCCCCCCC	27.75	29899451
958	Methylation	GRLTPSPRGGPFNPG CCCCCCCCCCCCCCC	68.02	24129315
976	Phosphorylation	PLPASSPSSFDGPSP CCCCCCCCCCCCCCC	45.65	29899451
977	Phosphorylation	LPASSPSSFDGPSPP CCCCCCCCCCCCCCC	30.64	-
982	Phosphorylation	PSSFDGPSPPDPRSG CCCCCCCCCCCCCCC	55.37	29899451
1054	Phosphorylation	LALGPQPSLRGWRGG CCCCCCCCCCCCCCC	26.00	20415495
1059	Methylation	QPSLRGWRGGGPSPT CCCCCCCCCCCCCCC	36.38	24129315
1067	O-linked_Glycosylation	GGGPSPTSGAPSPSH CCCCCCCCCCCCCCC	36.02	55413719
1076	Phosphorylation	APSPSHHSSSGGSSG CCCCCCCCCCCCCCC	22.30	29899451
1091	Methylation	PAQAPALRYFQLPPR CCCCCCHHHCCCCHH	32.12	58859517
1092	Phosphorylation	AQAPALRYFQLPPRA CCCCCHHHCCCCHHH	9.13	29899451
1098	Methylation	RYFQLPPRAASAAMY HHCCCCHHHCCCCEE	40.63	24129315
1101	Phosphorylation	QLPPRAASAAMYVPA CCCHHHCCCCEEEEC	18.64	25521595
1105	Phosphorylation	RAASAAMYVPARSGR HHCCCCEEEECCCCC	9.88	29899451
1109	Methylation	AAMYVPARSGRGRKG CCEEEECCCCCCCCC	33.31	24129315
1132	Phosphorylation	EGEPQKGSLPPASSP CCCCCCCCCCCCCCC	44.75	29899451
1137	Phosphorylation	KGSLPPASSPTSPAL CCCCCCCCCCCCCCC	42.50	29899451
1138	Phosphorylation	GSLPPASSPTSPALP CCCCCCCCCCCCCCC	34.01	29899451
1140	Phosphorylation	LPPASSPTSPALPRS CCCCCCCCCCCCCCC	49.65	29899451
1141	Phosphorylation	PPASSPTSPALPRSE CCCCCCCCCCCCCCC	16.15	29899451
1257	Asymmetric dimethylarginine	WQNEARRRSTLFLST CCCHHHHCCEEEEEC	28.56	-
1257	Methylation	WQNEARRRSTLFLST CCCHHHHCCEEEEEC	28.56	24129315
1258	Phosphorylation	QNEARRRSTLFLSTD CCHHHHCCEEEEECC	27.87	19060867
1259	Phosphorylation	NEARRRSTLFLSTDA CHHHHCCEEEEECCC	21.51	22807455
1263	Phosphorylation	RRSTLFLSTDAGDED HCCEEEEECCCCCCC	19.53	25521595
1264	Phosphorylation	RSTLFLSTDAGDEDG CCEEEEECCCCCCCC	31.83	25521595
1274	Phosphorylation	GDEDGGDSGLGPGAP CCCCCCCCCCCCCCC	38.91	22807455
1289	Phosphorylation	PGPRLRHSKSIDEGM CCCCCCCCCCCCCCC	22.97	20415495
1291	Phosphorylation	PRLRHSKSIDEGMFS CCCCCCCCCCCCCCC	37.98	25521595
1314	Phosphorylation	SGGSSGGYGAYAAGS CCCCCCCCCCCCCCC	11.34	29899451
1355	Phosphorylation	GKALDPASPLGLALA CCCCCCCCHHHHHHH	26.50	29899451
1369	Acetylation	AARERALKESSEGGV HHHHHHHHHHCCCCC	55.34	15613523
1386	Phosphorylation	QPPPRPPSPRYDAPP CCCCCCCCCCCCCCC	25.37	22817900
1403	Phosphorylation	LHHHSPHSPHSPHAR CCCCCCCCCCCCCCC	27.91	29899451
1406	Phosphorylation	HSPHSPHSPHARHEP CCCCCCCCCCCCCCC	23.05	29899451
1416	Methylation	ARHEPVLRLWGDPAR CCCCCCHHHHCCHHH	28.73	58859527
1429	Dimethylation	ARRELGYRAGLGSQE HHHHHHHCCCCCCHH	22.00	-
1429	Methylation	ARRELGYRAGLGSQE HHHHHHHCCCCCCHH	22.00	24129315
1434	Phosphorylation	GYRAGLGSQEKALTA HHCCCCCCHHHHHHC	39.96	22324799
1440	Phosphorylation	GSQEKALTASPPAAR CCHHHHHHCCCHHHH	29.92	29899451
1442	Phosphorylation	QEKALTASPPAARRS HHHHHHCCCHHHHHH	26.61	24925903
1517	Phosphorylation	PAGTRGSSTEDGPGV CCCCCCCCCCCCCCC	38.34	30372032
1518	Phosphorylation	AGTRGSSTEDGPGVP CCCCCCCCCCCCCCC	39.53	30372032
1528	Phosphorylation	GPGVPPPSPRRVLPT CCCCCCCCCCCCCCC	36.49	23527152
1535	Phosphorylation	SPRRVLPTSPTSPRG CCCCCCCCCCCCCCC	43.08	29899451
1536	Phosphorylation	PRRVLPTSPTSPRGN CCCCCCCCCCCCCCC	25.00	22324799
1538	Phosphorylation	RVLPTSPTSPRGNEE CCCCCCCCCCCCCCC	51.64	22324799
1539	Phosphorylation	VLPTSPTSPRGNEEN CCCCCCCCCCCCCCC	18.91	22324799
1875	O-linked_Glycosylation	ALATVKASIISELSS HHHHHHHHHHHHHHH	18.10	55413727
1901	Methylation	GGALPWARGGSGGST CCCCCCCCCCCCCCC	46.25	24129315
1904	Phosphorylation	LPWARGGSGGSTDSH CCCCCCCCCCCCCCC	42.69	30372032
1907	Phosphorylation	ARGGSGGSTDSHHGG CCCCCCCCCCCCCCC	32.35	29899451
1916	Phosphorylation	DSHHGGASYIPERTS CCCCCCCCCCCCCCC	27.20	29899451
1922	O-linked_Glycosylation	ASYIPERTSSLQRQR CCCCCCCCCHHHHHH	22.47	55413711
2006	Phosphorylation	PLLRRAPSPSLLPAS CHHHCCCCCCCCCCC	26.57	29899451
2008	Phosphorylation	LRRAPSPSLLPASDH HHCCCCCCCCCCCCC	47.04	29899451
2013	O-linked_Glycosylation	SPSLLPASDHKVSPA CCCCCCCCCCCCCCC	38.00	55413735
2022	Methylation	HKVSPAPRPSSLPIL CCCCCCCCCCCCCCC	45.93	24129315
2024	Phosphorylation	VSPAPRPSSLPILPS CCCCCCCCCCCCCCC	45.87	29899451
2025	Phosphorylation	SPAPRPSSLPILPSG CCCCCCCCCCCCCCC	40.63	29899451
2042	Methylation	YPGLFDIRSSPTGGA CCCCEECCCCCCCCC	32.69	24129315
2043	Phosphorylation	PGLFDIRSSPTGGAG CCCEECCCCCCCCCC	40.79	24925903
2044	Phosphorylation	GLFDIRSSPTGGAGG CCEECCCCCCCCCCC	19.34	29899451
2046	Phosphorylation	FDIRSSPTGGAGGSA EECCCCCCCCCCCCC	50.63	24925903
2052	Phosphorylation	PTGGAGGSADPFAPV CCCCCCCCCCCCCCE	28.69	22807455
2080	Methylation	GALSGASRSLSPTRL HHHCCCCCCCCCCCH	40.87	24129315
2081	Phosphorylation	ALSGASRSLSPTRLL HHCCCCCCCCCCCHH	30.61	21454597
2083	Phosphorylation	SGASRSLSPTRLLSL CCCCCCCCCCCHHCC	26.02	21454597
2089	Phosphorylation	LSPTRLLSLPPDKPF CCCCCHHCCCCCCCC	43.34	21454597

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SHAN1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SHAN1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SHAN1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SHAN1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.