TPP2_MOUSE - dbPTM
TPP2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TPP2_MOUSE
UniProt AC Q64514
Protein Name Tripeptidyl-peptidase 2
Gene Name Tpp2
Organism Mus musculus (Mouse).
Sequence Length 1262
Subcellular Localization Cytoplasm . Nucleus . Translocates to the nucleus in responce to gamma-irradiation.
Protein Description Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited (By similarity). Stimulates adipogenesis..
Protein Sequence MATAATEEPFPFHGLLPKKETGASSFLCRYPEYDGRGVLIAVLDTGVDPGAPGMQVTTDGKPKIIDIIDTTGSGDVNTATEVEPKDGEIIGLSGRVLKIPANWTNPLGKYHIGIKNGYDFYPKALKERIQKERKEKIWDPIHRVALAEACRKQEEFDIANNGSSQANKLIKEELQSQVELLNSFEKKYSDPGPVYDCLVWHDGETWRACVDSNENGDLSKCAVLRNYKEAQEYSSFGTAEMLNYSVNIYDDGNLLSIVTSGGAHGTHVASIAAGHFPEEPERNGVAPGAQILSIKIGDTRLSTMETGTGLIRAMIEVINHKCDLVNYSYGEATHWPNSGRICEVINEAVWKHNTIYVSSAGNNGPCLSTVGCPGGTTSSVIGVGAYVSPDMMVAEYSLREKLPANQYTWSSRGPSADGALGVSISAPGGAIASVPNWTLRGTQLMNGTSMSSPNACGGIALVLSGLKANNVDYTVHSVRRALENTAIKADNIEVFAQGHGIIQVDKAYDYLIQNTSFANRLGFTVTVGNNRGIYLRDPVQVAAPSDHGVGIEPVFPENTENSEKISFQLHLALTSNSSWVQCPSHLELMNQCRHINIRVDPRGLREGLHYTEVCGYDIASPNAGPLFRVPITAVIAAKVNESSHYDLAFTDVHFKPGQIRRHFVEVPEGATWAEVTVCSCSSEVSAKFVLHAVQLVKQRAYRSHEFYKFCSLPEKGTLIEAFPVLGGKAIEFCIARWWASLSDVNIDYTISFHGIVCTAPQLNIHASEGINRFDVQSSLKYEDLAPCITLKSWVQTLRPVNAKTRPLGSRDVLPNNRQLYEMVLTYSFHQPKSGEVTPSCPLLCELLYESEFDSQLWIIFDQNKRQMGSGDAYPHQYSLKLEKGDYTIRLQIRHEQISDLDRLKDLPFIVSHRLSNTLSLDIHENHSLALLGKKKSSSLTLPPKYNQPFFVTSLPDDKIPKGAGPGCYLAGSLTLSKTELGKKAGQSAAKRQGKFKKDVIPVHYYLIPPPTKIKNGSKDKEKDSEKEKDLKEEFTEALRDLKIQWMTKLDSTDIYNELKETYPAYLPLYVARLHQLDAEKERMKRLNEIVDAANAVISHIDQTALAVYIAMKTDPRPDAATIKNDMDKQKSTLIDALCRKGCALADHLLHTQPHDGAAAGDAEAKEEEGESTMESLSETYWETTKWTDLFDTKVLIFAYKHALVNKMYGRGLKFATKLVEEKPTKENWKNCIQLMKLLGWTHCASFTENWLPIMYPPDYCVF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MATAATEEP
------CCCCCCCCC		19.76-
19MalonylationFHGLLPKKETGASSF
CCCCCCCCCCCCCCE		59.5826320211
19AcetylationFHGLLPKKETGASSF
CCCCCCCCCCCCCCE		59.58-
19 (in isoform 2)Ubiquitination-59.5822790023
19UbiquitinationFHGLLPKKETGASSF
CCCCCCCCCCCCCCE		59.58-
28GlutathionylationTGASSFLCRYPEYDG
CCCCCEEEECCCCCC		3.5524333276
30PhosphorylationASSFLCRYPEYDGRG
CCCEEEECCCCCCCC		10.22-
61 (in isoform 2)Ubiquitination-46.0422790023
61UbiquitinationMQVTTDGKPKIIDII
CEEECCCCCEEEEEE		46.0422790023
85UbiquitinationTATEVEPKDGEIIGL
CCEEECCCCCCEEEE		65.93-
98 (in isoform 2)Ubiquitination-43.7322790023
98UbiquitinationGLSGRVLKIPANWTN
EEECCEEEECCCCCC		43.7322790023
109 (in isoform 2)Ubiquitination-41.1422790023
109UbiquitinationNWTNPLGKYHIGIKN
CCCCCCCCEEEEEEC		41.1422790023
115 (in isoform 2)Ubiquitination-38.8222790023
115UbiquitinationGKYHIGIKNGYDFYP
CCEEEEEECCCCCCH		38.8222790023
123AcetylationNGYDFYPKALKERIQ
CCCCCCHHHHHHHHH		55.7866699967
136 (in isoform 2)Ubiquitination-52.7322790023
136UbiquitinationIQKERKEKIWDPIHR
HHHHHHHHCCCHHHH		52.7322790023
150S-nitrosocysteineRVALAEACRKQEEFD
HHHHHHHHHHHCCCC		4.15-
150S-palmitoylationRVALAEACRKQEEFD
HHHHHHHHHHHCCCC		4.1528680068
150S-nitrosylationRVALAEACRKQEEFD
HHHHHHHHHHHCCCC		4.1520925432
152UbiquitinationALAEACRKQEEFDIA
HHHHHHHHHCCCCCC		63.0422790023
152 (in isoform 2)Ubiquitination-63.0422790023
186UbiquitinationELLNSFEKKYSDPGP
HHHHHHHHHCCCCCC		55.8122790023
186 (in isoform 2)Ubiquitination-55.8122790023
187AcetylationLLNSFEKKYSDPGPV
HHHHHHHHCCCCCCE		42.67-
209S-nitrosylationDGETWRACVDSNENG
CCCEEEEEECCCCCC		2.3421278135
209S-nitrosocysteineDGETWRACVDSNENG
CCCEEEEEECCCCCC		2.34-
209GlutathionylationDGETWRACVDSNENG
CCCEEEEEECCCCCC		2.3424333276
302PhosphorylationKIGDTRLSTMETGTG
EECCEEECCCHHCHH		23.5521183079
308PhosphorylationLSTMETGTGLIRAMI
ECCCHHCHHHHHHHH		35.9121183079
401AcetylationAEYSLREKLPANQYT
EEECHHHCCCCCCCC		54.0223806337
401 (in isoform 2)Ubiquitination-54.0222790023
401UbiquitinationAEYSLREKLPANQYT
EEECHHHCCCCCCCC		54.0222790023
467MethylationALVLSGLKANNVDYT
HHHHCCHHHCCCCHH		53.22-
614S-nitrosocysteineGLHYTEVCGYDIASP
CCCEEEECCCCCCCC		3.21-
614S-nitrosylationGLHYTEVCGYDIASP
CCCEEEECCCCCCCC		3.2120925432
642PhosphorylationIAAKVNESSHYDLAF
EEEECCCCCCCEEEE		19.7425367039
643PhosphorylationAAKVNESSHYDLAFT
EEECCCCCCCEEEEE		21.6425367039
645PhosphorylationKVNESSHYDLAFTDV
ECCCCCCCEEEEEEC		18.0125367039
655AcetylationAFTDVHFKPGQIRRH
EEEECCCCCCCEEEE		33.1023954790
655 (in isoform 2)Ubiquitination-33.1022790023
655UbiquitinationAFTDVHFKPGQIRRH
EEEECCCCCCCEEEE		33.1022790023
697AcetylationLHAVQLVKQRAYRSH
HHHHHHHHHHHHHCC		42.5322826441
708MalonylationYRSHEFYKFCSLPEK
HHCCCHHHHCCCCCC		45.2626320211
708 (in isoform 2)Acetylation-45.26-
708 (in isoform 2)Ubiquitination-45.2622790023
708AcetylationYRSHEFYKFCSLPEK
HHCCCHHHHCCCCCC		45.2623201123
708UbiquitinationYRSHEFYKFCSLPEK
HHCCCHHHHCCCCCC		45.26-
715 (in isoform 2)Ubiquitination-56.0822790023
715UbiquitinationKFCSLPEKGTLIEAF
HHCCCCCCCCEEEEE		56.0822790023
791 (in isoform 2)Ubiquitination-33.3522790023
791UbiquitinationLAPCITLKSWVQTLR
HHHHEEHHHHHHHCC		33.3522790023
820PhosphorylationLPNNRQLYEMVLTYS
CCCCHHHHEEHHEEE		8.1425168779
825PhosphorylationQLYEMVLTYSFHQPK
HHHEEHHEEEECCCC		13.0025168779
826PhosphorylationLYEMVLTYSFHQPKS
HHEEHHEEEECCCCC		12.7425168779
827PhosphorylationYEMVLTYSFHQPKSG
HEEHHEEEECCCCCC		15.8325168779
880UbiquitinationYPHQYSLKLEKGDYT
CCCEEEEEECCCCEE		48.9722790023
880AcetylationYPHQYSLKLEKGDYT
CCCEEEEEECCCCEE		48.9722826441
880 (in isoform 2)Ubiquitination-48.9722790023
883AcetylationQYSLKLEKGDYTIRL
EEEEEECCCCEEEEE		68.4722826441
883 (in isoform 2)Acetylation-68.47-
883 (in isoform 2)Ubiquitination-68.4722790023
883UbiquitinationQYSLKLEKGDYTIRL
EEEEEECCCCEEEEE		68.47-
883MalonylationQYSLKLEKGDYTIRL
EEEEEECCCCEEEEE		68.4726320211
904AcetylationISDLDRLKDLPFIVS
CCCHHHHCCCCEEEE		59.1022826441
915PhosphorylationFIVSHRLSNTLSLDI
EEEEECCCCCCCEEE		27.94-
958UbiquitinationVTSLPDDKIPKGAGP
EEECCCCCCCCCCCC		69.1827667366
958AcetylationVTSLPDDKIPKGAGP
EEECCCCCCCCCCCC		69.1823236377
961MalonylationLPDDKIPKGAGPGCY
CCCCCCCCCCCCCCE		65.9426320211
967GlutathionylationPKGAGPGCYLAGSLT
CCCCCCCCEEECEEE		2.5724333276
991 (in isoform 2)Phosphorylation-45.8429514104
1018 (in isoform 2)Ubiquitination-74.37-
1031UbiquitinationSEKEKDLKEEFTEAL
CHHHHHHHHHHHHHH		66.3922790023
1031 (in isoform 2)Ubiquitination-66.3922790023
1067 (in isoform 2)Ubiquitination-14.68-
1080 (in isoform 2)Ubiquitination-52.9522790023
1080UbiquitinationLHQLDAEKERMKRLN
HHHHHHHHHHHHHHH		52.9522790023
1193 (in isoform 2)Ubiquitination-36.57-
1193UbiquitinationWTDLFDTKVLIFAYK
HHHCCCHHHHHHHHH		36.5727667366
1200UbiquitinationKVLIFAYKHALVNKM
HHHHHHHHHHHHHHH		20.9727667366
1204 (in isoform 2)Acetylation-7.21-
1204 (in isoform 2)Ubiquitination-7.21-
1204UbiquitinationFAYKHALVNKMYGRG
HHHHHHHHHHHHHHH		7.2127667366
1206UbiquitinationYKHALVNKMYGRGLK
HHHHHHHHHHHHHHH		26.4822790023
1206 (in isoform 2)Ubiquitination-26.4822790023
1206AcetylationYKHALVNKMYGRGLK
HHHHHHHHHHHHHHH		26.4822826441
1209UbiquitinationALVNKMYGRGLKFAT
HHHHHHHHHHHHHHH		17.4327667366
1212 (in isoform 2)Ubiquitination-3.87-
1213UbiquitinationKMYGRGLKFATKLVE
HHHHHHHHHHHHHHH		35.4627667366
1217UbiquitinationRGLKFATKLVEEKPT
HHHHHHHHHHHCCCC		47.2927667366
1217AcetylationRGLKFATKLVEEKPT
HHHHHHHHHHHCCCC		47.2923201123
1217MalonylationRGLKFATKLVEEKPT
HHHHHHHHHHHCCCC		47.2926320211
1217 (in isoform 2)Ubiquitination-47.2922790023
1222MalonylationATKLVEEKPTKENWK
HHHHHHCCCCHHHHH		44.4726320211
1222UbiquitinationATKLVEEKPTKENWK
HHHHHHCCCCHHHHH		44.4727667366
1225UbiquitinationLVEEKPTKENWKNCI
HHHCCCCHHHHHHHH		58.5422790023
1225 (in isoform 2)Ubiquitination-58.5422790023
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TPP2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TPP2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TPP2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TPP2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TPP2_MOUSE

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Related Literatures of Post-Translational Modification

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