CTTB2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CTTB2_MOUSE
• UniProt AC: B9EJA2
• Protein Name: Cortactin-binding protein 2
• Gene Name: Cttnbp2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1648
• Subcellular Localization: Cytoplasm, cell cortex. Cell projection, dendritic spine. Remains associated with dendritic spines even after glutamate stimulation..
• Protein Description: Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance..
• Protein Sequence: MATDSASCEPDLSRTPGDTEGATAEAAKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRARRKEVFIQERYGRFNLNDPFLALQRDYEAGPGDKEKPVCTNPLSILEAVMAHCRKMQERMSAQLVAAESRQKKLEMEKLQLQALEQEHKKLAAHLEEERGKNKHVVLMLVKECKQLSGKVVEEAQKLEEVMAQLEEEKKKTSELEEQLSAEKQRSSGMEAQLEKQLSEFDTEREQLRAKLSREEAHTTDLKEEIDKMKKMMEQMKKGSDGKPGLSLPRKTKDKRLASISVATEGPVTRSVACQTDVVTESTDPVKKLPLTVPIKPSTGSPLVPTNTKGNVGPSALLIRPGIDRQSSHSDLGPSPPTALPSSANRIEENGPSTGNAPDLSNSTPSTPSSTAPAAAQTPGTAPQNHSQAPTVHSLHSPCANTHPGLNPRIQAARFRFQGNANDPDQNGNNTQSPPSRDVSPTSRDNLVAKQLARNTVTQALSRFTSPQAGASSRLGVSPGGDAGTCPPVGRTGLKTPGAARVDRGNPPPIPPKKPGLSQTPSPPHPQLRASNAGAKVDNKIVASPPSTLPQGTKVVNEENVPKSSSPQLPPKPSIDLTVAPAGCPVSALATSQVGAWPAGTPGLNQPACSDSSLVIPATVAFCSSINPVSASSRSPGASDSLLVAASGWSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLNAEARVDAADKNGFTPLCVAAAQGHFECIELLTAYNANINHSAAGGQTPLYLACKNGNKECIKLLLEAGTDRSIKTRDGWTPIHAAVDTGNVDSLKLLMYHRVRAHGNSLSSEEPKSGLFSLNGGESPTGPSKPVVPADLINHADKEGWTAAHIAASKGFKNCLEVLCRHGGLEPERRDKCNRTVHDVATDDCKHLLENLNALKIPLRISVGEIQPSNDVSDDFECEHTICTLNIRKQTSWEDFSKAVSQALTNHFQAISSDGWWSLEDGTFNNATDSCIGLGTSSIRSIMLGSMPWSTGQSFSQSPWDFLKKKKVEQVLALLSGPQEGCLSSVTYASMIPLQMLQNYLRLVEQYHNVIFHGPEGSLQDYIANQLALCMKYRQMAAGFPCEIVRAEVDSGFSKEQLVDVFIRNACLIPVKQFPVKKKIIVILENLEKSSLSELLGDFLAPLENRSTESPCTFQKGNGTSECYYFHENCFLVGTIAKACLQGSDLLVQQHFRWVQLRWDCEPIQGLLQRFLRRKVVSKFRGQLPAPCDPVCKIVDWALSVWRQLNSCLARLGTPEALLGPKYFLSCPVVPGHAQATVKWMSKLWNAVIAPRVQEAILSRASMNKQPGTGQTASKKYPSQGQQAVVRAALSILLNKAVLHGCPLPRAELDQQIADFKGGSFPLSIVSSYSKKKVESGAWRKVNTSPRKKPGHFSSPTWNKPDPKREGMRNKTIPHLNTNRNSSLSKQQSLENDLSVTLTLDHRLSLGSDDEADLVKELQSMCSSKSESDISKIADSRDDLRKFDSSRTNPGTSAPLNLRTPVPQKEASPPSSRQTAECSNSKSKTEMGVSSVKSFLPVPRSKVAQCSQNTKRNSSSSNTRQLEINNNSKEENWTLDKHEQVEKPNK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Ubiquitination	FDVDTLSKSELRMLL CCHHHCCHHHHHHHH		22790023
269	Acetylation	KKMMEQMKKGSDGKP HHHHHHHHCCCCCCC		7706107
279	Phosphorylation	SDGKPGLSLPRKTKD CCCCCCCCCCCCCCC		-
291	Phosphorylation	TKDKRLASISVATEG CCCCCEEEEEEECCC		29899451
359	Phosphorylation	RPGIDRQSSHSDLGP CCCCCCCCCCCCCCC		20415495
360	Phosphorylation	PGIDRQSSHSDLGPS CCCCCCCCCCCCCCC		21183079
362	Phosphorylation	IDRQSSHSDLGPSPP CCCCCCCCCCCCCCC		21183079
367	Phosphorylation	SHSDLGPSPPTALPS CCCCCCCCCCCCCCC		20415495
370	Phosphorylation	DLGPSPPTALPSSAN CCCCCCCCCCCCCCC		20415495
374	Phosphorylation	SPPTALPSSANRIEE CCCCCCCCCCCCCHH		20415495
375	Phosphorylation	PPTALPSSANRIEEN CCCCCCCCCCCCHHC		20415495
463	Phosphorylation	PDQNGNNTQSPPSRD CCCCCCCCCCCCCCC		29899451
472	Phosphorylation	SPPSRDVSPTSRDNL CCCCCCCCCCCHHHH		25521595
474	Phosphorylation	PSRDVSPTSRDNLVA CCCCCCCCCHHHHHH		22324799
475	Phosphorylation	SRDVSPTSRDNLVAK CCCCCCCCHHHHHHH		22324799
495	Asymmetric dimethylarginine	TVTQALSRFTSPQAG HHHHHHHHHCCCCCC		-
495	Methylation	TVTQALSRFTSPQAG HHHHHHHHHCCCCCC		24129315
554	Phosphorylation	PGLSQTPSPPHPQLR CCCCCCCCCCCCCCC		20415495
576	Phosphorylation	VDNKIVASPPSTLPQ CCCEEECCCCCCCCC		29899451
580	O-linked_Glycosylation	IVASPPSTLPQGTKV EECCCCCCCCCCCEE		55411695
580	Phosphorylation	IVASPPSTLPQGTKV EECCCCCCCCCCCEE		-
911	Phosphorylation	TAAHIAASKGFKNCL HHHHHHHCCCHHHHH		24759943
1422	Phosphorylation	IADFKGGSFPLSIVS HHHHCCCCCCHHHHC		26643407
1426	Phosphorylation	KGGSFPLSIVSSYSK CCCCCCHHHHCCCCC		26643407
1429	Phosphorylation	SFPLSIVSSYSKKKV CCCHHHHCCCCCCCC		26643407
1430	Phosphorylation	FPLSIVSSYSKKKVE CCHHHHCCCCCCCCC		26643407
1431	Phosphorylation	PLSIVSSYSKKKVES CHHHHCCCCCCCCCC		26643407
1432	Phosphorylation	LSIVSSYSKKKVESG HHHHCCCCCCCCCCC		26643407
1435	Acetylation	VSSYSKKKVESGAWR HCCCCCCCCCCCCCE		6566061
1507	Phosphorylation	LTLDHRLSLGSDDEA EEEECCHHCCCCCHH		22817900
1510	Phosphorylation	DHRLSLGSDDEADLV ECCHHCCCCCHHHHH		25521595
1528	Phosphorylation	QSMCSSKSESDISKI HHHHCCCCHHHHHHH		23375375
1544	Ubiquitination	DSRDDLRKFDSSRTN CCHHHHHHHCCCCCC		-
1544	Acetylation	DSRDDLRKFDSSRTN CCHHHHHHHCCCCCC		22826441
1604	Methylation	FLPVPRSKVAQCSQN HCCCCHHHHHHHCCC		-
1607 (in isoform 4)	Phosphorylation	-		25266776
1608 (in isoform 4)	Phosphorylation	-		25266776
1613	Methylation	AQCSQNTKRNSSSSN HHHCCCCCCCCCCCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CTTB2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CTTB2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CTTB2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CTTB2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.