WASF1_MOUSE - dbPTM
WASF1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WASF1_MOUSE
UniProt AC Q8R5H6
Protein Name Wiskott-Aldrich syndrome protein family member 1
Gene Name Wasf1
Organism Mus musculus (Mouse).
Sequence Length 559
Subcellular Localization Cytoplasm, cytoskeleton . Cell junction, synapse . Cell junction, focal adhesion . Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas. Partial translocation to focal adhesion sites might be mediated by interactio
Protein Description Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. [PubMed: 27605705]
Protein Sequence MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAHSFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIPLQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQKQKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDADLLHKHIEVANGPASHYETRPQTYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPTPTCISSATGLIENRPQSPAAGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEVQGLPPPPPPPPLPPPGIRPSSPVAVAALAHPPSGLHPAPSTAPGPHAPLMPPSPPSQVLPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIAVEYSDSEDDSEFDEVDWLE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
63PhosphorylationFNEAHSFSFRVNSLQ
HHHHHHCEEEHHHHH		18.3728973931
91PhosphorylationDPKEEELSLQDITMR
CCCCCCCCHHHHHHH		27.5428066266
96PhosphorylationELSLQDITMRKAFRS
CCCHHHHHHHHHHHC		21.1528066266
103PhosphorylationTMRKAFRSSTIQDQQ
HHHHHHHCCCCCCHH		25.9425338131
156PhosphorylationKFYTNPSYFFDLWKE
EECCCHHHHHHHHHH		14.99-
162UbiquitinationSYFFDLWKEKMLQDT
HHHHHHHHHHHCCCC		55.5422790023
293PhosphorylationGAGDAKPTPTCISSA
CCCCCCCCCCCCCCC		30.4429899451
295PhosphorylationGDAKPTPTCISSATG
CCCCCCCCCCCCCCC		25.5829233185
298PhosphorylationKPTPTCISSATGLIE
CCCCCCCCCCCCCCC		18.9629233185
299PhosphorylationPTPTCISSATGLIEN
CCCCCCCCCCCCCCC		15.2229233185
301PhosphorylationPTCISSATGLIENRP
CCCCCCCCCCCCCCC		34.1729899451
310PhosphorylationLIENRPQSPAAGRTP
CCCCCCCCCCCCCCC		21.1329899451
333PhosphorylationPPPPPLPSALSTSSL
CCCCCCCCCCCCHHH		49.9121183079
336PhosphorylationPPLPSALSTSSLRAS
CCCCCCCCCHHHCCC		26.4219060867
337PhosphorylationPLPSALSTSSLRASM
CCCCCCCCHHHCCCC		24.1619060867
338PhosphorylationLPSALSTSSLRASMT
CCCCCCCHHHCCCCC		24.8120415495
339PhosphorylationPSALSTSSLRASMTS
CCCCCCHHHCCCCCC		23.2023140645
341Asymmetric dimethylarginineALSTSSLRASMTSTP
CCCCHHHCCCCCCCC		26.94-
341MethylationALSTSSLRASMTSTP
CCCCHHHCCCCCCCC		26.9424129315
397PhosphorylationAPPLVQPSPPVARAA
CCCCCCCCCCCCCCC		25.4122817900
441PhosphorylationPPGIRPSSPVAVAAL
CCCCCCCCCCHHHHH		26.5222817900
489PhosphorylationSEPKRHPSTLPVISD
CCCCCCCCCCCHHCH		36.1327841257
490PhosphorylationEPKRHPSTLPVISDA
CCCCCCCCCCHHCHH		39.2625338131
523UbiquitinationEQREQEAKHERIEND
HHHHHHHHHHHHHHH		45.2922790023
533PhosphorylationRIENDVATILSRRIA
HHHHHHHHHHHHHHE		23.4628066266
536PhosphorylationNDVATILSRRIAVEY
HHHHHHHHHHHEEEE		18.7020415495
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of WASF1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WASF1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WASF1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
P85A_MOUSEPik3r1physical
21946561
CYFP1_MOUSECyfip1physical
21946561
NCKP1_MOUSENckap1physical
21946561
NYAP1_MOUSENyap1physical
21946561
NYAP2_MOUSENyap2physical
21946561
MYO16_MOUSEMyo16physical
21946561
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WASF1_MOUSE

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Related Literatures of Post-Translational Modification

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