NYAP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NYAP1_MOUSE
• UniProt AC: Q6PFX7
• Protein Name: Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1
• Gene Name: Nyap1
• Organism: Mus musculus (Mouse).
• Sequence Length: 833
• Protein Description: Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis..
• Protein Sequence: MNLLYRKTKLEWRQHKEEEAKRSSSKEAAPTGPVGPGAVPGPGVRVRDIASLRRSLRMGFMTMPASQEHTPHPCRSTMAPRSLSCHSVGSMDSVGGGPGGGLTEDSSTRRPPAKPRRHPSTKLSMAGPGAETPPSKKAGSQKPAPECRESSRKVPPQKPRRSPNTQLSVSFDESCAPAPSPRGANLPLQRLSRASRITGDLDAGAQEEEPVYIEMVGDVFRGGGRSGGGLAGPPLGSGGPTPPAAADSDSEDSEAIYEEMKYPLPEEAGDGRANGPPPLTAPSPPQQTHILQPHPHPHRRPASALPSRRDGTPTKTTPCEIPPPFPNLLQHRPPLLAFPQAKSASRAPGDGVSRLPVLCHSKEPAGSTPAPQVPARERETPPLPPPPPAANLLLLGPSGRARSHSTPLPPQGSGQTRGERELPNSHSMICPKAAGVPAAHPAPAALLPGPPKDKAVSYTMVYSAVKVTTHSVLPAGPPLGVGEPKTEEISVLHGMLCASSRPPVPGKSSPHSGAMGSAAGVLHHRSCLASPHSLPDPTGGSLTPLWTYPATAAGLKRPPAYDSLKAGGVLNKGCGMGAPSPMVKIQLQEQGTDGGAFASISCAHVIASAGTPEEEEEMGAAFGAGWALQRKVLYGGRKAKEVDTEEDGARAWNGSTEGPGKVEHEDRGPVPSGIPVRSQGAEGLLARIHHDRGGSRTALPVPCQTFPACHRNGDFTGGYRLGRSASTSGVRQAALHTPRPCSQPRDALSQTHPVLPLPLPPQPARERDGKLLEVIERKRCVCKEIKARHRPDRGLCKQESMPILPSWRRVPEPRKSGTPPCRRQHTVLWDTAI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Phosphorylation	VRVRDIASLRRSLRM CCHHHHHHHHHHHHH	23.81	24719451
82	Phosphorylation	RSTMAPRSLSCHSVG CCCCCCCCCCCCCCC	24.47	19060867
84	Phosphorylation	TMAPRSLSCHSVGSM CCCCCCCCCCCCCCC	15.84	19060867
87	Phosphorylation	PRSLSCHSVGSMDSV CCCCCCCCCCCCCCC	32.28	19060867
90	Phosphorylation	LSCHSVGSMDSVGGG CCCCCCCCCCCCCCC	19.77	19060867
93	Phosphorylation	HSVGSMDSVGGGPGG CCCCCCCCCCCCCCC	17.64	22807455
162	Phosphorylation	PPQKPRRSPNTQLSV CCCCCCCCCCCCEEE	24.63	22324799
165	Phosphorylation	KPRRSPNTQLSVSFD CCCCCCCCCEEEEEC	33.98	22324799
168	Phosphorylation	RSPNTQLSVSFDESC CCCCCCEEEEECCCC	13.09	29899451
170	Phosphorylation	PNTQLSVSFDESCAP CCCCEEEEECCCCCC	24.49	29899451
174	Phosphorylation	LSVSFDESCAPAPSP EEEEECCCCCCCCCC	19.88	22324799
212	Phosphorylation	AQEEEPVYIEMVGDV CCCCCCEEEEEECCC	11.24	25177544
257	Phosphorylation	SEDSEAIYEEMKYPL CCCHHHHHHHHCCCC	16.94	-
380	Phosphorylation	VPARERETPPLPPPP CCCCCCCCCCCCCCC	36.11	22324799
416	Phosphorylation	PPQGSGQTRGERELP CCCCCCCCCCCCCCC	44.13	24719451
468	O-linked_Glycosylation	VYSAVKVTTHSVLPA EEEEEEEEECCCCCC	17.05	55411945
486	Phosphorylation	LGVGEPKTEEISVLH CCCCCCCCHHHHHHC	49.95	24719451
508	Phosphorylation	RPPVPGKSSPHSGAM CCCCCCCCCCCCCCC	55.83	21149613
509	Phosphorylation	PPVPGKSSPHSGAMG CCCCCCCCCCCCCCC	30.07	21149613
512	Phosphorylation	PGKSSPHSGAMGSAA CCCCCCCCCCCCCCH	31.47	21149613
517	Phosphorylation	PHSGAMGSAAGVLHH CCCCCCCCCHHHHHH	11.23	21149613
705	Phosphorylation	ALPVPCQTFPACHRN CCCCCCCCCCCCCCC	38.00	29899451
800	Phosphorylation	RGLCKQESMPILPSW CCCCCCCCCCCCCCC	27.62	22324799

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NYAP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NYAP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NYAP1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCKP1_MOUSE	Nckap1	physical	21946561
P85A_MOUSE	Pik3r1	physical	21946561

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.