NCKP1_MOUSE - dbPTM
NCKP1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NCKP1_MOUSE
UniProt AC P28660
Protein Name Nck-associated protein 1
Gene Name Nckap1
Organism Mus musculus (Mouse).
Sequence Length 1128
Subcellular Localization Cell membrane
Single-pass membrane protein
Cytoplasmic side . Cell projection, lamellipodium membrane
Single-pass membrane protein
Cytoplasmic side . Cytoplasm . At the interface between the lamellipodial actin meshwork and the membrane.
Protein Description Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. [PubMed: 27605705]
Protein Sequence MSRSVLQPSQQKLAEKLTILNDRGVGMLTRLYNIKKACGDPKAKPSYLIDKNLESAVKFIVRKFPAVETRNNNQQLAQLQKEKSEILKNLALYYFTFVDVMEFKDHVCDLLNTIDVCQVFFDITVNFDLTKNYLDLTVTYTTLMILLSRIEERKAIIGLYNYAHEMTHGASDREYPRLGQMIVDYENPLKKMMEEFVPHSKSLSDALISLQMVYPRRNLSADQWRNAQLLSLISAPSTMLNPAQSDTMPCEYLSLDAMEKWIIFGFILCHGMLNTEATALNLWKLALQSSSCLSLFRDEVFHIHKAAEDLFVNIRGYNKRINDIRECKEAAVSHAGSMHRERRKFLRSALKELATVLSDQPGLLGPKALFVFMALSFARDEIIWLLRHADNMPKKSADDFIDKHIAELIFYMEELRAHVRKYGPVMQRYYVQYLSGFDAVVLNELVQNLSVCPEDESIIMSSFVNTMTSLSVKQVEDGEVFDFRGMRLDWFRLQAYTSVSKASLSLADHRELGKMMNTIIFHTKMVDSLVEMLVETSDLSIFCFYSRAFEKMFQQCLELPSQSRYSIAFPLLCTHFMSCTHELCPEERHHIGDRSLSLCNMFLDEMAKQARNLITDICTEQCTLSDQLLPKHCAKTISQAVNKKSKKQTGKKGEPEREKPGVESMRKNRLVVTNLDKLHTALSELCFSINYVPNMAVWEHTFTPREYLTSHLEIRFTKSIVGMTMYNQATQEIAKPSELLTSVRAYMTVLQSIENYVQIDITRVFNNVLLQQTQHLDSHGEPTITSLYTNWYLETLLRQVSNGHIAYFPAMKAFVNLPTENELTFNAEEYSDISEMRSLSELLGPYGMKFLSESLMWHISSQVAELKKLVVENVDVLTQMRTSFDKPDQMAALFKRLSSVDSVLKRMTIIGVILSFRSLAQEALRDVLSYHIPFLVSSIEDFKDHIPRETDMKVAMNVYELSSAAGLPCEIDPALVVALSSQKSENISPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIEGHCNNIHCLAKAINQIAAALFTIHKGSIEDRLKEFLALASSSLLKIGQETDKTTTRNRESVYLLLDMIVQESPFLTMDLLESCFPYVLLRNAYHAVYKQSVTSSA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSRSVLQPS
------CCCCCCCHH		44.56-
2Phosphorylation------MSRSVLQPS
------CCCCCCCHH		44.5623984901
4Phosphorylation----MSRSVLQPSQQ
----CCCCCCCHHHH		36.1523984901
12UbiquitinationVLQPSQQKLAEKLTI
CCCHHHHHHHHHHHH		41.87-
16UbiquitinationSQQKLAEKLTILNDR
HHHHHHHHHHHHHHC		45.37-
32PhosphorylationVGMLTRLYNIKKACG
HHHHHHHHHHHHHHC		16.1418779572
58UbiquitinationKNLESAVKFIVRKFP
CCHHHHHHHHHHHCC		29.14-
83UbiquitinationLAQLQKEKSEILKNL
HHHHHHHHHHHHHHH		61.50-
191AcetylationDYENPLKKMMEEFVP
CCCCHHHHHHHHHCC		51.6819850881
289PhosphorylationLWKLALQSSSCLSLF
HHHHHHHCCHHHHHH		25.68-
290PhosphorylationWKLALQSSSCLSLFR
HHHHHHCCHHHHHHH		16.47-
291PhosphorylationKLALQSSSCLSLFRD
HHHHHCCHHHHHHHH		25.07-
333PhosphorylationECKEAAVSHAGSMHR
HHHHHHHHHCCHHHH		11.68-
337PhosphorylationAAVSHAGSMHRERRK
HHHHHCCHHHHHHHH		16.5228285833
411PhosphorylationHIAELIFYMEELRAH
HHHHHHHHHHHHHHH		9.1624759943
551UbiquitinationFYSRAFEKMFQQCLE
HHHHHHHHHHHHHHC		38.26-
561PhosphorylationQQCLELPSQSRYSIA
HHHHCCCCCCCCCHH		54.1129899451
563PhosphorylationCLELPSQSRYSIAFP
HHCCCCCCCCCHHHH		37.2129899451
597PhosphorylationHIGDRSLSLCNMFLD
CCCHHHHHHHHHHHH		31.9329899451
645PhosphorylationSQAVNKKSKKQTGKK
HHHHHHHHHHCCCCC		46.85-
664PhosphorylationREKPGVESMRKNRLV
CCCCCHHHHHHCCEE		22.8329899451
840PhosphorylationISEMRSLSELLGPYG
HHHHHHHHHHHHHHH		27.6925338131
886UbiquitinationQMRTSFDKPDQMAAL
HHCCCCCCHHHHHHH		48.78-
886AcetylationQMRTSFDKPDQMAAL
HHCCCCCCHHHHHHH		48.787743731
895AcetylationDQMAALFKRLSSVDS
HHHHHHHHHHHCHHH		53.967743741
895UbiquitinationDQMAALFKRLSSVDS
HHHHHHHHHHHCHHH		53.96-
1056UbiquitinationGSIEDRLKEFLALAS
CCHHHHHHHHHHHHH		47.52-
1065PhosphorylationFLALASSSLLKIGQE
HHHHHHHHHHHHCCC		34.9124453211
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NCKP1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NCKP1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NCKP1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ABI1_MOUSEAbi1physical
28671696
ABI2_MOUSEAbi2physical
28671696
AP2A1_MOUSEAp2a1physical
28671696
BAIP2_MOUSEBaiap2physical
28671696
KCC2A_MOUSECamk2aphysical
28671696
CYFP1_MOUSECyfip1physical
28671696
CYFP2_MOUSECyfip2physical
28671696
DYN1_MOUSEDnm1physical
28671696
DPYL2_MOUSEDpysl2physical
28671696
E41L1_MOUSEEpb4.1l1physical
28671696
E41L3_MOUSEEpb4.1l3physical
28671696
GSK3B_MOUSEGsk3bphysical
28671696
NFL_MOUSENeflphysical
28671696
NFM_MOUSENefmphysical
28671696
RAC1_MOUSERac1physical
28671696
SGIP1_MOUSESgip1physical
28671696
SPTB2_MOUSESptbn1physical
28671696
TNIK_MOUSETnikphysical
28671696
TSC1_MOUSETsc1physical
28671696
WASF1_MOUSEWasf1physical
28671696
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NCKP1_MOUSE

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory