SGIP1_MOUSE - dbPTM
SGIP1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SGIP1_MOUSE
UniProt AC Q8VD37
Protein Name SH3-containing GRB2-like protein 3-interacting protein 1
Gene Name Sgip1
Organism Mus musculus (Mouse).
Sequence Length 806
Subcellular Localization Membrane, clathrin-coated pit
Peripheral membrane protein
Cytoplasmic side .
Protein Description May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis..
Protein Sequence MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGMQPSPHEPPYHSKAECAREGGKKASKKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKKFNIKIKPLQSKDVLKNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARPRRSTPTPELTSKKPLDDTLALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPMNPSTESPELARPFPTGTPPPLPPKTVPATPPRTGSPLTVATGNDQAATEAKIEKLPSISDLDSIFGPVLSPKSVAVNTEEKWVHFSDASPEHVTPELTPREQVVTPPAASDIPADSPAPAPPGPTGSAGPPGPPGPRHVPSPLNLEEVQKKVAEQTFIKDDYLETLSSPKECGLGQRATPPPPPPPTYRTVVSSPGPGSGSGTGTTSGASSPARPATPLVPCSTTPPPPPPRPPSRPKLPPGKPGVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPAGITRHFANNPSPAALTFRVVNSSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHLKKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPASTDLRIDYKYNTDAMSTAVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
22PhosphorylationIRKKEKDTDSTGSPD
CCCCCCCCCCCCCCC		42.8129899451
22 (in isoform 3)Phosphorylation-42.8129899451
22 (in isoform 4)Phosphorylation-42.8129899451
24PhosphorylationKKEKDTDSTGSPDRD
CCCCCCCCCCCCCCC		36.4419060867
24 (in isoform 3)Phosphorylation-36.4429899451
24 (in isoform 4)Phosphorylation-36.4429899451
24 (in isoform 6)Phosphorylation-36.4429899451
25PhosphorylationKEKDTDSTGSPDRDG
CCCCCCCCCCCCCCC		44.4819060867
25 (in isoform 3)Phosphorylation-44.4829899451
25 (in isoform 4)Phosphorylation-44.4829899451
25 (in isoform 6)Phosphorylation-44.4829899451
27PhosphorylationKDTDSTGSPDRDGMQ
CCCCCCCCCCCCCCC		24.5821930439
27 (in isoform 3)Phosphorylation-24.5829899451
27 (in isoform 4)Phosphorylation-24.5829899451
27 (in isoform 6)Phosphorylation-24.5829899451
35 (in isoform 3)Phosphorylation-40.7229899451
35 (in isoform 4)Phosphorylation-40.7229899451
36PhosphorylationDRDGMQPSPHEPPYH
CCCCCCCCCCCCCCC		23.2326643407
42PhosphorylationPSPHEPPYHSKAECA
CCCCCCCCCCHHHHH		29.4623375375
44PhosphorylationPHEPPYHSKAECARE
CCCCCCCCHHHHHHC		27.9329899451
76PhosphorylationAEIDWERYNSPELDE
EEEEHHHCCCCCCCC		14.4225521595
78PhosphorylationIDWERYNSPELDEEG
EEHHHCCCCCCCCCC		15.7125521595
86PhosphorylationPELDEEGYSIRPEEP
CCCCCCCCCCCCCCC		12.2825521595
87PhosphorylationELDEEGYSIRPEEPG
CCCCCCCCCCCCCCC		23.9924925903
95PhosphorylationIRPEEPGSTKGKHFY
CCCCCCCCCCCCCCC		37.3525521595
96PhosphorylationRPEEPGSTKGKHFYS
CCCCCCCCCCCCCCC		50.1325521595
102PhosphorylationSTKGKHFYSSSESEE
CCCCCCCCCCCCCHH		13.8322324799
103PhosphorylationTKGKHFYSSSESEEE
CCCCCCCCCCCCHHH		26.8318388127
104PhosphorylationKGKHFYSSSESEEEE
CCCCCCCCCCCHHHH		27.0918388127
105PhosphorylationGKHFYSSSESEEEEE
CCCCCCCCCCHHHHH		38.9218388127
107PhosphorylationHFYSSSESEEEEESH
CCCCCCCCHHHHHHH		52.8618388127
113PhosphorylationESEEEEESHKKFNIK
CCHHHHHHHHHCCCE		43.8429899451
126PhosphorylationIKIKPLQSKDVLKNA
CEECCCCCHHHHHHC		38.2129899451
135PhosphorylationDVLKNAATVDELKAS
HHHHHCCCHHHHHHH		26.5329899451
142PhosphorylationTVDELKASIGNIALS
CHHHHHHHHCCEECC		29.4629899451
149PhosphorylationSIGNIALSPSPVRKS
HHCCEECCCCCCCCC		17.8223527152
151PhosphorylationGNIALSPSPVRKSPR
CCEECCCCCCCCCCC		32.4322324799
156PhosphorylationSPSPVRKSPRRSPGA
CCCCCCCCCCCCCCH		17.0522324799
160PhosphorylationVRKSPRRSPGAIKRN
CCCCCCCCCCHHHCC		29.0328382018
169PhosphorylationGAIKRNLSSEEVARP
CHHHCCCCHHHHCCC		38.9725521595
170PhosphorylationAIKRNLSSEEVARPR
HHHCCCCHHHHCCCC		40.7325521595
179PhosphorylationEVARPRRSTPTPELT
HHCCCCCCCCCCCCC		39.7625521595
180PhosphorylationVARPRRSTPTPELTS
HCCCCCCCCCCCCCC		29.3925521595
182PhosphorylationRPRRSTPTPELTSKK
CCCCCCCCCCCCCCC		29.5025521595
186PhosphorylationSTPTPELTSKKPLDD
CCCCCCCCCCCCCCC		36.5230372032
187PhosphorylationTPTPELTSKKPLDDT
CCCCCCCCCCCCCCC		51.8425521595
214PhosphorylationSAFDEQKTEVLLDQP
HCCCHHHCEEEECCC		30.9020415495
226PhosphorylationDQPEIWGSGQPMNPS
CCCCHHCCCCCCCCC		21.1825293948
231 (in isoform 2)Phosphorylation-33.7721183079
233PhosphorylationSGQPMNPSTESPELA
CCCCCCCCCCCCCCC		39.5424925903
233 (in isoform 2)Phosphorylation-39.5421183079
234PhosphorylationGQPMNPSTESPELAR
CCCCCCCCCCCCCCC		41.5624925903
236PhosphorylationPMNPSTESPELARPF
CCCCCCCCCCCCCCC		24.6224925903
236 (in isoform 2)Phosphorylation-24.6228066266
239 (in isoform 2)Phosphorylation-5.7828066266
242 (in isoform 2)Phosphorylation-33.6821183079
243 (in isoform 2)Phosphorylation-7.6321183079
245PhosphorylationELARPFPTGTPPPLP
CCCCCCCCCCCCCCC		54.8124925903
247PhosphorylationARPFPTGTPPPLPPK
CCCCCCCCCCCCCCC		34.7924925903
255PhosphorylationPPPLPPKTVPATPPR
CCCCCCCCCCCCCCC		37.1825521595
255 (in isoform 2)Phosphorylation-37.1822807455
259PhosphorylationPPKTVPATPPRTGSP
CCCCCCCCCCCCCCC		27.9625521595
262 (in isoform 3)Phosphorylation-53.5821183079
262 (in isoform 4)Phosphorylation-53.5821183079
263PhosphorylationVPATPPRTGSPLTVA
CCCCCCCCCCCCEEE		48.0325521595
264 (in isoform 3)Phosphorylation-28.6621183079
264 (in isoform 4)Phosphorylation-28.6621183079
265PhosphorylationATPPRTGSPLTVATG
CCCCCCCCCCEEEEC		19.0025521595
267 (in isoform 2)Phosphorylation-6.8722807455
267 (in isoform 3)Phosphorylation-6.8728066266
267 (in isoform 4)Phosphorylation-6.8728066266
268PhosphorylationPRTGSPLTVATGNDQ
CCCCCCCEEEECCCH		16.1025521595
270 (in isoform 3)Phosphorylation-12.4528066266
270 (in isoform 4)Phosphorylation-12.4528066266
271PhosphorylationGSPLTVATGNDQAAT
CCCCEEEECCCHHHH		31.9829899451
273 (in isoform 3)Phosphorylation-33.5921183079
273 (in isoform 4)Phosphorylation-33.5921183079
274 (in isoform 3)Phosphorylation-40.6221183079
274 (in isoform 4)Phosphorylation-40.6221183079
278PhosphorylationTGNDQAATEAKIEKL
ECCCHHHHHHHHHHC		39.2228576409
286 (in isoform 3)Phosphorylation-40.4622807455
286 (in isoform 4)Phosphorylation-40.4622807455
287PhosphorylationAKIEKLPSISDLDSI
HHHHHCCCHHHHHHH		45.2025521595
289PhosphorylationIEKLPSISDLDSIFG
HHHCCCHHHHHHHCC		36.1425521595
293PhosphorylationPSISDLDSIFGPVLS
CCHHHHHHHCCCCCC		27.4125177544
298 (in isoform 3)Phosphorylation-9.4022807455
298 (in isoform 4)Phosphorylation-9.4022807455
300PhosphorylationSIFGPVLSPKSVAVN
HHCCCCCCCCEEEEC		30.4325521595
316PhosphorylationEEKWVHFSDASPEHV
CCCEEECCCCCCCCC		19.8625521595
319PhosphorylationWVHFSDASPEHVTPE
EEECCCCCCCCCCCC		35.4925521595
324PhosphorylationDASPEHVTPELTPRE
CCCCCCCCCCCCCHH		16.9825521595
328PhosphorylationEHVTPELTPREQVVT
CCCCCCCCCHHHCCC		20.7324925903
335PhosphorylationTPREQVVTPPAASDI
CCHHHCCCCCCHHCC		25.3825521595
336 (in isoform 3)Phosphorylation-12.6229899451
337 (in isoform 3)Phosphorylation-30.9629899451
338 (in isoform 3)Phosphorylation-22.3222807455
339 (in isoform 3)Phosphorylation-17.3229899451
340PhosphorylationVVTPPAASDIPADSP
CCCCCCHHCCCCCCC		37.8724925903
341 (in isoform 3)Phosphorylation-46.2820415495
342 (in isoform 3)Phosphorylation-2.5422807455
343 (in isoform 3)Phosphorylation-34.7020415495
345 (in isoform 3)Phosphorylation-50.2020415495
346PhosphorylationASDIPADSPAPAPPG
HHCCCCCCCCCCCCC		25.6825521595
347 (in isoform 3)Phosphorylation-42.6920415495
355PhosphorylationAPAPPGPTGSAGPPG
CCCCCCCCCCCCCCC		50.0824925903
357PhosphorylationAPPGPTGSAGPPGPP
CCCCCCCCCCCCCCC		32.3124925903
371PhosphorylationPGPRHVPSPLNLEEV
CCCCCCCCCCCHHHH		40.7125521595
376 (in isoform 3)Phosphorylation-55.8627841257
392PhosphorylationQTFIKDDYLETLSSP
HHCCCHHHHHHCCCC		19.3024925903
395PhosphorylationIKDDYLETLSSPKEC
CCHHHHHHCCCCCCC		29.3724925903
397PhosphorylationDDYLETLSSPKECGL
HHHHHHCCCCCCCCC		52.6022324799
398PhosphorylationDYLETLSSPKECGLG
HHHHHCCCCCCCCCC		43.0025521595
409PhosphorylationCGLGQRATPPPPPPP
CCCCCCCCCCCCCCC		38.2225521595
436PhosphorylationSGSGTGTTSGASSPA
CCCCCCCCCCCCCCC		26.8929899451
437PhosphorylationGSGTGTTSGASSPAR
CCCCCCCCCCCCCCC		32.0022807455
440PhosphorylationTGTTSGASSPARPAT
CCCCCCCCCCCCCCC		40.1429899451
441PhosphorylationGTTSGASSPARPATP
CCCCCCCCCCCCCCC		23.2629899451
447PhosphorylationSSPARPATPLVPCST
CCCCCCCCCCCCCCC		21.6021183079
453PhosphorylationATPLVPCSTTPPPPP
CCCCCCCCCCCCCCC		29.2821183079
455PhosphorylationPLVPCSTTPPPPPPR
CCCCCCCCCCCCCCC		19.9421082442
465PhosphorylationPPPPRPPSRPKLPPG
CCCCCCCCCCCCCCC		64.9919060867
480PhosphorylationKPGVGDVSRPFSPPI
CCCCCCCCCCCCCCC		38.6924925903
484PhosphorylationGDVSRPFSPPIHSSS
CCCCCCCCCCCCCCC		32.2325521595
489PhosphorylationPFSPPIHSSSPPPIA
CCCCCCCCCCCCCCC		32.9825521595
490PhosphorylationFSPPIHSSSPPPIAP
CCCCCCCCCCCCCCC		32.4724925903
491PhosphorylationSPPIHSSSPPPIAPL
CCCCCCCCCCCCCCC		44.4324925903
503PhosphorylationAPLARAESTSSISST
CCCCCCCCCCCCCCC		32.3829899451
503 (in isoform 8)Phosphorylation-32.3829899451
504 (in isoform 8)Phosphorylation-20.2829899451
505PhosphorylationLARAESTSSISSTNS
CCCCCCCCCCCCCCC		34.6521183079
505 (in isoform 8)Phosphorylation-34.6522807455
506PhosphorylationARAESTSSISSTNSL
CCCCCCCCCCCCCCC		26.9529899451
506 (in isoform 8)Phosphorylation-26.9529899451
508PhosphorylationAESTSSISSTNSLSA
CCCCCCCCCCCCCCC		32.8129899451
508 (in isoform 8)Phosphorylation-32.8120415495
509PhosphorylationESTSSISSTNSLSAA
CCCCCCCCCCCCCCC		29.9121183079
509 (in isoform 8)Phosphorylation-29.9122807455
510PhosphorylationSTSSISSTNSLSAAT
CCCCCCCCCCCCCCC		23.2629899451
510 (in isoform 8)Phosphorylation-23.2620415495
512 (in isoform 8)Phosphorylation-24.6420415495
514PhosphorylationISSTNSLSAATTPTV
CCCCCCCCCCCCCCC		18.7129899451
514 (in isoform 8)Phosphorylation-18.7120415495
517PhosphorylationTNSLSAATTPTVGSS
CCCCCCCCCCCCCCC		32.7829899451
528PhosphorylationVGSSRGPSPLTMGAQ
CCCCCCCCCCCCCCC		35.0529899451
531PhosphorylationSRGPSPLTMGAQDTL
CCCCCCCCCCCCCCC		19.5529899451
531 (in isoform 6)Phosphorylation-19.5529899451
532 (in isoform 6)Phosphorylation-5.7329899451
533 (in isoform 6)Phosphorylation-18.1722807455
534 (in isoform 6)Phosphorylation-8.0229899451
536 (in isoform 6)Phosphorylation-50.0720415495
537PhosphorylationLTMGAQDTLPVAAAF
CCCCCCCCCHHHHHH		22.3829899451
537 (in isoform 6)Phosphorylation-22.3822807455
538 (in isoform 6)Phosphorylation-4.2920415495
540 (in isoform 6)Phosphorylation-6.7820415495
542 (in isoform 6)Phosphorylation-11.8920415495
543 (in isoform 8)Phosphorylation-11.3627841257
558PhosphorylationYFKGADPSKCIVKIT
HHCCCCHHHEEEEEE		40.4819367708
571 (in isoform 6)Phosphorylation-20.1327841257
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SGIP1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SGIP1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SGIP1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SGIP1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SGIP1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169 AND SER-371, ANDMASS SPECTROMETRY.
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169; THR-263; SER-265;THR-268; THR-335 AND THR-409, AND MASS SPECTROMETRY.
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169; SER-300; SER-319AND THR-324, AND MASS SPECTROMETRY.
"Proteomic analysis of in vivo phosphorylated synaptic proteins.";
Collins M.O., Yu L., Coba M.P., Husi H., Campuzano I.,Blackstock W.P., Choudhary J.S., Grant S.G.;
J. Biol. Chem. 280:5972-5982(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169; THR-180; THR-182;THR-259; THR-263; SER-265; SER-287; SER-300; SER-316; SER-319; THR-324AND SER-371, AND MASS SPECTROMETRY.

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