MYO16_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYO16_MOUSE
• UniProt AC: Q5DU14
• Protein Name: Unconventional myosin-XVI
• Gene Name: Myo16 {ECO:0000312|MGI:MGI:2685951}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1919
• Subcellular Localization: Cytoplasm . Found in puncta in soma and processes of astrocytes and dissociated cerebellar cells with the morphology of migrating granule cells.
• Protein Description: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development (By similarity). Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis..
• Protein Sequence: MEIDQCLLESLPLGQRQRLVKRMRCEQIKAYYEREKVFQKQEGPLKRSKPGKRQKVRFGLADMIQDAVIHHHDKEVLQLLKEGADPHTLVSSGGSLLHLCARYDNVFIAEVLIDRGVNVNHQDEDFWTPMHIACACDNPDIVLLLILAGANVFLQDVNGNIPLDYAVEGTESSAILLAYLDEKGVDLSSLRQIKLQRPLSMLTDVRHFLSSGGDVNEKNDDGVTLLHMACASGYKEVVLLLLEHGGDLNGTDDRYWTPLHLAAKYGQTTLVKLLLAHQANPHLVNCNGEKPSDIAASESIEEMLLKAEIAWEEKMKESPSAPSLAQEELYEILHDLPDLSSKLSPLVLPIAKQDSLLEKDIMFKDTTKGLCKQESQDGPPETSMTSNCGKPEQVQVMPPAPSDDLATLSELNDSSLLYEIQKRFGNDQIHTFIGDIFLLVNPFKELPIYSTMVSQMYLSPTGQRSPSLPPHLFSCAERAFHRLFQERKPQNIILSGERGSGKTQASKQIMKYLTSRASSSCTMFDSRLRHAIYIVEAFGHAKTTLNNVSSCLIQYWELQCCQRRKHITGARISTYMLEKSRVVAQPPGQGTFLIFSWLMDGLSSEEKCGLHLNNFCAHRYVSQGMREDVSTAEHSLNKERLAALKHALNVIGFSTLEVENLFVILSAILHIGDIQFTALTEADSAFVSDLQLLEQVAGMLQVSTDELASALTTDIQYFKGDVIIRRHTIQMAAFYRDLLAKSLYSRLFGFLINTVNCCLQNQDEYKSLQTLDIGILDIFGFEEFQKNEFEQLCVNLTNEKMHHYIQEVLFLQEQTECVQEGVAMETACSPGNQAGVLDFFFQKPSGFFSLLDEESQVIWSGEPNLPRKLQGLLESSNTNAVYSPVKDGNGNVAFKGQGAAFTVMHYAGRVMYEMGGAVERNKDSLSQNLLFVMKTSENVVISHLFQSKLSQTGSLISSYPSFKFGGHKSTLLSKRTASSMVGVNKNYLELSKLLKKKGTSTFLQRLERGEPATAASQLTKSLADITAKLQRGSPHFILCIKPNTSQLPGVFDHFYVSAQLQYLGVLGLVRLFRSGYPVRPSFEDFLSRYEPLASVLLGETKGQAAEERCRLVLQRCKLQGWQIGVHKVFLKYWHVDQLSDLWLQLQRKIVTCQKVIRGFLARQHLLQRMSIKQQEVTSIKSFLQSTEDMALKTYDALVIQNASDIAREHDRLRKEVHTAYHRNRQEEGTKRAEDQGGCRHVHSNSVPVPMVVDSLAQALTGPSTRPPSLHSVFSMDDSTGLPSPRKQPPPKPKRDPNTRLSASYEAVSACLSAAKDAAGEALTRPRPHSDDYSTMKKIPPRKPKRSPHTKLSGSYEEIWGPPRPSGTMGQGGRHQAPGTLSVQWARPDSVPQCTPQLPLHLPLPQGDYDDDAEPVYIEMVGNAARAGGSETDSPDQGESVYEEMKYILPEEGCGLGMLTFLPASPPLFLETRKAIILEAAEGNCQPSKDTCDIPPPFPNLLPHRPPLLVFPPTPVTRSPASDESPLTPLEVKKLPVLETNLKYPVQSEGSSPLSPQYSKAQKGDNDQLASPGFPVFNGPSRISPPATPPPPPGPPPAPCGPPPAPCGPPPAPCGPPPAPCGPPPAPCGPPPAPCGAASASCGVAPAPCRPPTHFAFPPESVLVTAAKALTNSDLPRTQPKPSSAPVPGPCSSFVKAPYSPGKTARADLRKTSSTFSPPSPYSPPNSRPLSSPLDELASLFNSGRSVLRRSAVGRRIREAEGFETNMNLSSRDEPSSSEMASETQDRNANNHGTQLSSSLSSDVTAENGNPVTNGLAEDDGCSRLCLSGMGTSSFQRNRESHTTQVIHQLRLSENESVALQELLDWRRKLCEAREGWQEALQHPEPRAPPPPPCKKPTLLKKPEGGSCTRLPSQLWDSSM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
188	Phosphorylation	DEKGVDLSSLRQIKL HHCCCCHHHHHHHHC	23.90	25159016
189	Phosphorylation	EKGVDLSSLRQIKLQ HCCCCHHHHHHHHCC	34.56	25159016
355	Phosphorylation	LPIAKQDSLLEKDIM HHHHCCCCHHHCCCC	32.15	21082442
500	Phosphorylation	ILSGERGSGKTQASK EEECCCCCCHHHHHH	43.25	21454597
573	Phosphorylation	HITGARISTYMLEKS CCCCCCHHEEEEECC	14.13	22499769
574	Phosphorylation	ITGARISTYMLEKSR CCCCCHHEEEEECCC	15.58	22499769
575	Phosphorylation	TGARISTYMLEKSRV CCCCHHEEEEECCCE	7.91	22499769
728	Phosphorylation	DVIIRRHTIQMAAFY CEEEECCHHHHHHHH	15.87	-
961	Phosphorylation	SLISSYPSFKFGGHK CCHHCCCCCCCCCCH	32.60	28576409
991	Phosphorylation	NKNYLELSKLLKKKG CHHHHHHHHHHHHHC	16.33	22871156
1303	Phosphorylation	PNTRLSASYEAVSAC CCCCCCHHHHHHHHH	21.82	23527152
1332	Phosphorylation	PRPHSDDYSTMKKIP CCCCCCCCCHHCCCC	15.84	28576409
1416	Phosphorylation	DDDAEPVYIEMVGNA CCCCCCEEEEECCCH	11.24	-
1429	Phosphorylation	NAARAGGSETDSPDQ CHHHCCCCCCCCCCC	36.08	29899451
1431	Phosphorylation	ARAGGSETDSPDQGE HHCCCCCCCCCCCCC	43.40	29899451
1433	Phosphorylation	AGGSETDSPDQGESV CCCCCCCCCCCCCHH	37.48	29899451
1441	Phosphorylation	PDQGESVYEEMKYIL CCCCCHHHHHHHHHC	18.56	29899451
1524	Phosphorylation	RSPASDESPLTPLEV CCCCCCCCCCCCCCC	30.14	22807455
1527	Phosphorylation	ASDESPLTPLEVKKL CCCCCCCCCCCCCCC	29.25	22807455
1580	Phosphorylation	FPVFNGPSRISPPAT CCCCCCCCCCCCCCC	43.58	21454597

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYO16_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYO16_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYO16_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCKP1_MOUSE	Nckap1	physical	21946561
P85A_MOUSE	Pik3r1	physical	21946561

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1441, AND MASSSPECTROMETRY.
PubMed: 18034455