dbPTM

NYAP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NYAP2_MOUSE
UniProt AC	Q8BM65
Protein Name	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
Gene Name	Nyap2
Organism	Mus musculus (Mouse).
Sequence Length	682
Subcellular Localization
Protein Description	Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis..
Protein Sequence	MIPSKMMSANPEEDPLDTFFQYIEDMGMKAYDGLVIQNASDIARENDRLRNETKLAYLKEKNEKRRRQEETIKRIGGEVGRGQDASYAGKHFRMGFMTMPAPQDRLPHPCSSGFTVRSQSLHSVGGTEDDSSCGSRRQPPPKPKRDPSTKLSTSSETVNSTAASKSGRSLERAEGKFTVPASHSPPRASTSGHLFPSPGSQERNIKVSAKPRPHSDEYSKKIPPPKPKRNPNTQLSTSFDETYIKKHVPRRTSLPRDSSLSQVCSPAADPEEEEPVYIEMVGNILRDFRKEEDDQSEAVYEEMKYPIFDDLGHDSKCDFDHHSCSSQCATPTVPDLDFVKSSGPCTPKGLLCDIPPPFPNLLSHRPPLLVFPPAPVHCSPNSDESPLTPLEVTKLPVLENVSYMKQPPGACPSSLPSHGSSHAKDQTGALGPAPGASILSSSPPPPSTLYRTQSPHGYPKSHSTSPSPVSMGRSLTPLSLKRPPPYDAVHSGSLSRSSSSVPHTTPRPVSQDGAKMVNAAVNTYSAAQSGSRSRTPTSPLEELTSLFTSGRSLLRKSSSGRRSKEPAEKSTEELKVRSHSTEPLPKLDSKERGHYGSSSSREPVKAQEWDGTPGPPVVTSRMGRCSVSPTLLAGNHSSEPKVSCKLGRSASTSGVPPPSVTPLRQASDLQQSQVPSSLANRD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	Methylation	RIGGEVGRGQDASYA HHCCCCCCCCCCCCC	44.79	24129315
98	Phosphorylation	HFRMGFMTMPAPQDR CEECEEECCCCCCCC	20.10	22817900
118	Phosphorylation	SSGFTVRSQSLHSVG CCCEEEECCCEECCC	21.56	25521595
120	Phosphorylation	GFTVRSQSLHSVGGT CEEEECCCEECCCCC	29.33	22817900
123	Phosphorylation	VRSQSLHSVGGTEDD EECCCEECCCCCCCC	27.96	29899451
127	Phosphorylation	SLHSVGGTEDDSSCG CEECCCCCCCCCCCC	30.25	29899451
152	Phosphorylation	RDPSTKLSTSSETVN CCCCCCCCCCCCHHH	28.00	24759943
153	Phosphorylation	DPSTKLSTSSETVNS CCCCCCCCCCCHHHH	46.86	24759943
154	Phosphorylation	PSTKLSTSSETVNST CCCCCCCCCCHHHHH	23.85	29895711
155	Phosphorylation	STKLSTSSETVNSTA CCCCCCCCCHHHHHH	37.06	29895711
157	Phosphorylation	KLSTSSETVNSTAAS CCCCCCCHHHHHHHH	27.25	29899451
160	Phosphorylation	TSSETVNSTAASKSG CCCCHHHHHHHHCCC	18.32	29899451
161	Phosphorylation	SSETVNSTAASKSGR CCCHHHHHHHHCCCC	22.50	21454597
166	Phosphorylation	NSTAASKSGRSLERA HHHHHHCCCCCCEEC	36.62	29895711
169	Phosphorylation	AASKSGRSLERAEGK HHHCCCCCCEECCCC	37.80	19854140
182	Phosphorylation	GKFTVPASHSPPRAS CCEEECCCCCCCCCC	20.59	27841257
183 (in isoform 2)	Phosphorylation	-	46.56	27841257
183 (in isoform 5)	Phosphorylation	-	46.56	27841257
184	Phosphorylation	FTVPASHSPPRASTS EEECCCCCCCCCCCC	33.82	25521595
190	Phosphorylation	HSPPRASTSGHLFPS CCCCCCCCCCCCCCC	37.43	21183079
191	Phosphorylation	SPPRASTSGHLFPSP CCCCCCCCCCCCCCC	23.01	21183079
197	Phosphorylation	TSGHLFPSPGSQERN CCCCCCCCCCCCCCC	34.26	21183079
208	Phosphorylation	QERNIKVSAKPRPHS CCCCCEEECCCCCCC	26.10	29899451
215	Phosphorylation	SAKPRPHSDEYSKKI ECCCCCCCHHHHCCC	34.52	27841257
233	Phosphorylation	KPKRNPNTQLSTSFD CCCCCCCCCCCCCCC	31.95	29899451
236	Phosphorylation	RNPNTQLSTSFDETY CCCCCCCCCCCCHHH	16.52	29899451
238	Phosphorylation	PNTQLSTSFDETYIK CCCCCCCCCCHHHHH	27.59	25521595
252	Phosphorylation	KKHVPRRTSLPRDSS HHHCCCCCCCCCCCC	35.58	22324799
253	Phosphorylation	KHVPRRTSLPRDSSL HHCCCCCCCCCCCCH	34.27	22324799
258	Phosphorylation	RTSLPRDSSLSQVCS CCCCCCCCCHHHHCC	34.16	29899451
259	Phosphorylation	TSLPRDSSLSQVCSP CCCCCCCCHHHHCCC	36.01	29899451
261	Phosphorylation	LPRDSSLSQVCSPAA CCCCCCHHHHCCCCC	23.63	29899451
265	Phosphorylation	SSLSQVCSPAADPEE CCHHHHCCCCCCCCC	20.79	29899451
277	Phosphorylation	PEEEEPVYIEMVGNI CCCCCCCHHEEHHHH	11.24	21946561
300	Phosphorylation	DDQSEAVYEEMKYPI CCHHHHHHHHHCCCC	17.14	21946561
440	Phosphorylation	APGASILSSSPPPPS CCCCCHHCCCCCCCC	27.40	20415495
441	Phosphorylation	PGASILSSSPPPPST CCCCHHCCCCCCCCC	43.34	20415495
442	Phosphorylation	GASILSSSPPPPSTL CCCHHCCCCCCCCCC	37.74	25521595
448	Phosphorylation	SSPPPPSTLYRTQSP CCCCCCCCCCCCCCC	33.32	29899451
454	Phosphorylation	STLYRTQSPHGYPKS CCCCCCCCCCCCCCC	20.46	27841257
463	Phosphorylation	HGYPKSHSTSPSPVS CCCCCCCCCCCCCCC	37.36	25338131
464	Phosphorylation	GYPKSHSTSPSPVSM CCCCCCCCCCCCCCC	38.95	25338131
479	Phosphorylation	GRSLTPLSLKRPPPY CCCCCCCCCCCCCCC	32.80	27841257
491	O-linked_Glycosylation	PPYDAVHSGSLSRSS CCCCCCCCCCCCCCC	24.39	46237107
510	Phosphorylation	HTTPRPVSQDGAKMV CCCCCCCCCCHHHHH	25.82	23737553
533	Phosphorylation	AAQSGSRSRTPTSPL HHHCCCCCCCCCCHH	42.05	24759943
535	Phosphorylation	QSGSRSRTPTSPLEE HCCCCCCCCCCHHHH	31.97	25177544
537	Phosphorylation	GSRSRTPTSPLEELT CCCCCCCCCHHHHHH	42.22	24759943
538	Phosphorylation	SRSRTPTSPLEELTS CCCCCCCCHHHHHHH	28.79	25177544
544	Phosphorylation	TSPLEELTSLFTSGR CCHHHHHHHHHHHHH	27.02	20415495
545	Phosphorylation	SPLEELTSLFTSGRS CHHHHHHHHHHHHHH	33.82	20415495
549	Phosphorylation	ELTSLFTSGRSLLRK HHHHHHHHHHHHHHH	25.52	20415495
559	Phosphorylation	SLLRKSSSGRRSKEP HHHHHCCCCCCCCCC	43.33	-
580	Phosphorylation	ELKVRSHSTEPLPKL HHHHCCCCCCCCCCC	35.39	27841257
590	Acetylation	PLPKLDSKERGHYGS CCCCCCCCCCCCCCC	51.61	23576753
626	Phosphorylation	TSRMGRCSVSPTLLA ECCCCCCEECCEEEC	25.03	29899451
628	Phosphorylation	RMGRCSVSPTLLAGN CCCCCEECCEEECCC	8.89	27841257
649	Phosphorylation	VSCKLGRSASTSGVP EEEEECCCCCCCCCC	25.44	24759943
651	Phosphorylation	CKLGRSASTSGVPPP EEECCCCCCCCCCCC	25.09	24759943
652	Phosphorylation	KLGRSASTSGVPPPS EECCCCCCCCCCCCC	29.26	24759943
653	Phosphorylation	LGRSASTSGVPPPSV ECCCCCCCCCCCCCC	34.99	24759943
683 (in isoform 5)	Phosphorylation	-		22324799
689 (in isoform 5)	Phosphorylation	-		26824392
700 (in isoform 5)	Phosphorylation	-		30372032
715 (in isoform 4)	Phosphorylation	-		22324799
721 (in isoform 4)	Phosphorylation	-		26824392
732 (in isoform 4)	Phosphorylation	-		30372032

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
277	Y	Phosphorylation	Kinase	FYN	P39688	PSP
300	Y	Phosphorylation	Kinase	FYN	P39688	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NYAP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NYAP2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CYFP1_MOUSE	Cyfip1	physical	21946561
NCKP1_MOUSE	Nckap1	physical	21946561
RHG26_MOUSE	Arhgap26	physical	21946561
ACOT9_MOUSE	Acot9	physical	21946561
P85A_MOUSE	Pik3r1	physical	21946561

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NYAP2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain."; Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.; J. Proteome Res. 7:311-318(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-300, AND MASSSPECTROMETRY.	18034455 [Abstract]