CAD10_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAD10_MOUSE
• UniProt AC: P70408
• Protein Name: Cadherin-10
• Gene Name: Cdh10
• Organism: Mus musculus (Mouse).
• Sequence Length: 788
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types..
• Protein Sequence: MTIYQFLRLFVLWACLPHFCCPELTFRRTPGIQQMTAESRAPRSDGKILHRQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAGTLFIIDEKTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQGQPYFSVEPETGIIRTALPNMNRENKEQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQNTIHLRVLESSPVGTAVGSVKATDADTGKNAEVDYRIIDGDGTDMFDIITEKDTQEGIITVKKPLDYENRRLYTLKVEAENTHVDPRFYYLGPFKDTTIVKISIEDVDEPPVFSRSSYLFEVHEDIEVGTIIGTVMARDPDSTSSPIRFTLDRHTDLDRIFNIHSGNGSLYTSKPLDRELSQWHNLTVIAAEINNPKETTRVSVFVRILDVNDNAPQFAVFYDTFVCENARPGQLIQTISAVDKDDPLGGQKFFFSLAAVNPNFTVQDNEDNTARILTRKNGFNRHEISTYLLPVVISDNDYPIQSSTGTLTIRVCACDSQGNMQSCSAEALLLPAGLSTGALIAILLCIIILLVIVVLFAALKRQRKKEPLILSKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPAAIEEKKLRRDIIPETLFIPRRTPTAPDNTDVRDFINERLKEHDLDPTAPPYDSLATYAYEGNDSVAESLSSLESGTTEGDQNYDYLREWGPRFNKLAEMYGGGESDKDA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
256	N-linked_Glycosylation	LSGTTTVNITLTDVN CCCCEEEEEEEEECC	21.31	-
306	Phosphorylation	GKNAEVDYRIIDGDG CCCCEEEEEEECCCC	14.64	27841257
325	Phosphorylation	DIITEKDTQEGIITV EEEECCCCCCEEEEE	39.32	21454597
360	Phosphorylation	THVDPRFYYLGPFKD CCCCCCEEEECCCCC	10.08	28059163
456	N-linked_Glycosylation	RELSQWHNLTVIAAE HHHHHHCCEEEEEEE	34.15	-
534	N-linked_Glycosylation	SLAAVNPNFTVQDNE EEEEECCCCEEECCC	39.76	-
646	Phosphorylation	KKEPLILSKEDIRDN CCCCCEECHHHHHHC	27.31	25521595
656	Phosphorylation	DIRDNIVSYNDEGGG HHHHCCCCCCCCCCC	17.89	-
657	Phosphorylation	IRDNIVSYNDEGGGE HHHCCCCCCCCCCCC	18.75	29899451
701	Phosphorylation	TLFIPRRTPTAPDNT CCCCCCCCCCCCCCC	26.69	25521595
703	Phosphorylation	FIPRRTPTAPDNTDV CCCCCCCCCCCCCCH	50.65	29899451
784	Phosphorylation	EMYGGGESDKDA--- HHHCCCCCCCCC---	53.92	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAD10_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAD10_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAD10_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CAD10_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.