NHSL2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NHSL2_MOUSE
• UniProt AC: B1AXH1
• Protein Name: NHS-like protein 2
• Gene Name: Nhsl2
• Organism: Mus musculus (Mouse).
• Sequence Length: 854
• Protein Sequence: MESMAVVYSVPSSCNGPTESTFSTSWKGDAFTYMTPSASSQGNQVSENGKNPSSGNSWVPLNTLPPLVPKEAATLFVTRDNPAGCTGLPSYSEHPTLRRQIPERPPKIGLLARGTSRLETGPGGTNRFRERSLSVPTDSGVTSVDYDEEQKTSETRILPYASTSSEGSNSTDNIAALSTEQEARHRRQRSKSISLKKAKKKPSPPMRSVSLVKDEPALPPEGELVLPKDQRPRSLCLSLEHQGHHPPHPDAQGHPAVPMLKDPGSTQFSHHWYLTDWKSGDTYQSLSSSSTATGTTVIECTQVQGSSESLASPSTSRATTPSQLSIEVEAREVASPGRPTGLMSPSSGYSSQSETPTPTVSMSLTLGHLPPPSASVRVRPVVPERKSSLPPTSPMEKICKSRLSFDLPLTSSTTLDLSGMSISIRSKTKVSRHHSDTNFGVKLAQKTSPNQPIMPMVTQSDLRSVRLRSVSKSEPEDDIESPDYIEEPGAEEVFTMPERKVKPPIAEKPPLARRPPSLVHRPPSLPGEYPLTSPTMAMASRSSIPHMKQLPQDSYTVLRKPKSPSFPGESTASSSLVLSPLASSSGAFFSGTQQPPQASVEDGGPKVRALPERIGLQSQEEAEKKMTKIPPPVPKKPSVLYLPLTSPVAQMDACMAEPRLPFSPIITLEEDGKCPSTGDDQKSPGKGVTSPLHTDTEKEAISPGRSVEPSAEEKSLISDKTAEWIAEEEDDVFVASRTTEDLFTVIHRSKRKLLGWKETGEGFTGSKPSSHSPVKNTADSPTGEAAAAPGPSSSACLDAGRNDDFKALLQKKGSKATPRTRPSAAELLKTTNPLARRIIAQFSKDYEPTDNPST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	SSQGNQVSENGKNPS HHCCCCCCCCCCCCC	18.64	-
115	Phosphorylation	IGLLARGTSRLETGP CEEEECCCCCCCCCC	12.72	26026062
116	Phosphorylation	GLLARGTSRLETGPG EEEECCCCCCCCCCC	37.38	29176673
120	Phosphorylation	RGTSRLETGPGGTNR CCCCCCCCCCCCCCC	53.95	29176673
132	Phosphorylation	TNRFRERSLSVPTDS CCCCCEECCCCCCCC	21.90	28833060
134	Phosphorylation	RFRERSLSVPTDSGV CCCEECCCCCCCCCC	27.57	25521595
137	Phosphorylation	ERSLSVPTDSGVTSV EECCCCCCCCCCCCC	40.41	28833060
139	Phosphorylation	SLSVPTDSGVTSVDY CCCCCCCCCCCCCCC	37.33	28833060
142	Phosphorylation	VPTDSGVTSVDYDEE CCCCCCCCCCCCCCC	26.93	29899451
143	Phosphorylation	PTDSGVTSVDYDEEQ CCCCCCCCCCCCCCC	15.58	28833060
160	Phosphorylation	SETRILPYASTSSEG CCEEEECCCCCCCCC	15.11	28609623
162	Phosphorylation	TRILPYASTSSEGSN EEEECCCCCCCCCCC	23.99	30635358
163	Phosphorylation	RILPYASTSSEGSNS EEECCCCCCCCCCCC	28.27	30635358
164	Phosphorylation	ILPYASTSSEGSNST EECCCCCCCCCCCCH	24.73	30635358
165	Phosphorylation	LPYASTSSEGSNSTD ECCCCCCCCCCCCHH	46.17	30635358
168	Phosphorylation	ASTSSEGSNSTDNIA CCCCCCCCCCHHCCE	24.45	28609623
170	Phosphorylation	TSSEGSNSTDNIAAL CCCCCCCCHHCCEEC	38.54	28609623
171	Phosphorylation	SSEGSNSTDNIAALS CCCCCCCHHCCEECC	37.00	30635358
178	Phosphorylation	TDNIAALSTEQEARH HHCCEECCHHHHHHH	25.77	30635358
179	Phosphorylation	DNIAALSTEQEARHR HCCEECCHHHHHHHH	42.40	30635358
192	Phosphorylation	HRRQRSKSISLKKAK HHHHHHHCCCHHHHC	20.75	29176673
195	Phosphorylation	QRSKSISLKKAKKKP HHHHCCCHHHHCCCC	6.68	-
203	Phosphorylation	KKAKKKPSPPMRSVS HHHCCCCCCCCCCEE	50.98	19854140
208	Phosphorylation	KPSPPMRSVSLVKDE CCCCCCCCEEECCCC	15.14	25162660
210	Phosphorylation	SPPMRSVSLVKDEPA CCCCCCEEECCCCCC	28.79	25162660
234	Phosphorylation	PKDQRPRSLCLSLEH CCCCCCCCEEEEECC	26.56	26060331
261	Phosphorylation	HPAVPMLKDPGSTQF CCCCCCCCCCCCCCC	56.47	29899451
265	Phosphorylation	PMLKDPGSTQFSHHW CCCCCCCCCCCEEEE	25.15	29899451
284	Phosphorylation	WKSGDTYQSLSSSST CCCCCCEEHHCCCCC	39.73	-
284	Phosphorylation	WKSGDTYQSLSSSST CCCCCCEEHHCCCCC	39.73	25521595
290	Phosphorylation	YQSLSSSSTATGTTV EEHHCCCCCCCCCEE	24.82	-
293	Phosphorylation	LSSSSTATGTTVIEC HCCCCCCCCCEEEEE	34.84	-
299	Phosphorylation	ATGTTVIECTQVQGS CCCCEEEEEEEECCC	27.46	25521595
300	Phosphorylation	TGTTVIECTQVQGSS CCCEEEEEEEECCCC	1.90	24719451
300	Phosphorylation	TGTTVIECTQVQGSS CCCEEEEEEEECCCC	1.90	27742792
301	Phosphorylation	GTTVIECTQVQGSSE CCEEEEEEEECCCCC	20.98	-
301	Phosphorylation	GTTVIECTQVQGSSE CCEEEEEEEECCCCC	20.98	29472430
303	Phosphorylation	TVIECTQVQGSSESL EEEEEEEECCCCCCC	3.61	29472430
305	Phosphorylation	IECTQVQGSSESLAS EEEEEECCCCCCCCC	33.99	29550500
306	Phosphorylation	ECTQVQGSSESLASP EEEEECCCCCCCCCC	17.53	-
316	Phosphorylation	SLASPSTSRATTPSQ CCCCCCCCCCCCCCC	25.02	-
319	Phosphorylation	SPSTSRATTPSQLSI CCCCCCCCCCCCEEE	37.82	19060867
319	Phosphorylation	SPSTSRATTPSQLSI CCCCCCCCCCCCEEE	37.82	23684622
320	Phosphorylation	PSTSRATTPSQLSIE CCCCCCCCCCCEEEE	21.69	27180971
322	Phosphorylation	TSRATTPSQLSIEVE CCCCCCCCCEEEEEE	41.48	20415495
325	Phosphorylation	ATTPSQLSIEVEARE CCCCCCEEEEEEEEE	14.74	22324799
338	Phosphorylation	REVASPGRPTGLMSP EECCCCCCCCCCCCC	29.05	27180971
340	Phosphorylation	VASPGRPTGLMSPSS CCCCCCCCCCCCCCC	41.40	29472430
341	Phosphorylation	ASPGRPTGLMSPSSG CCCCCCCCCCCCCCC	23.28	-
341	Phosphorylation	ASPGRPTGLMSPSSG CCCCCCCCCCCCCCC	23.28	30372032
347	Phosphorylation	TGLMSPSSGYSSQSE CCCCCCCCCCCCCCC	45.17	-
347	Phosphorylation	TGLMSPSSGYSSQSE CCCCCCCCCCCCCCC	45.17	29899451
348	Phosphorylation	GLMSPSSGYSSQSET CCCCCCCCCCCCCCC	30.58	-
348	Phosphorylation	GLMSPSSGYSSQSET CCCCCCCCCCCCCCC	30.58	23684622
349	Phosphorylation	LMSPSSGYSSQSETP CCCCCCCCCCCCCCC	13.70	24719451
349	Phosphorylation	LMSPSSGYSSQSETP CCCCCCCCCCCCCCC	13.70	23684622
387	Phosphorylation	PVVPERKSSLPPTSP ECCCCCCCCCCCCCH	43.24	29899451
388	Phosphorylation	VVPERKSSLPPTSPM CCCCCCCCCCCCCHH	48.18	29899451
392	Phosphorylation	RKSSLPPTSPMEKIC CCCCCCCCCHHHHHH	43.45	29899451
404	Phosphorylation	KICKSRLSFDLPLTS HHHHHCCCCCCCCCC	18.66	29899451
411	Phosphorylation	SFDLPLTSSTTLDLS CCCCCCCCCEEEECC	33.11	29899451
412	Phosphorylation	FDLPLTSSTTLDLSG CCCCCCCCEEEECCC	21.85	29899451
435	Phosphorylation	TKVSRHHSDTNFGVK CEECCCCCCCCHHHE	39.75	26824392
437	Phosphorylation	VSRHHSDTNFGVKLA ECCCCCCCCHHHEEC	35.15	29233185
447	Phosphorylation	GVKLAQKTSPNQPIM HHEECCCCCCCCCCC	37.02	29899451
448	Phosphorylation	VKLAQKTSPNQPIMP HEECCCCCCCCCCCC	28.96	26745281
469	Phosphorylation	LRSVRLRSVSKSEPE HHHEEEECCCCCCCC	35.02	23737553
471	Phosphorylation	SVRLRSVSKSEPEDD HEEEECCCCCCCCCC	31.54	23737553
473	Phosphorylation	RLRSVSKSEPEDDIE EEECCCCCCCCCCCC	51.37	27180971
481	Phosphorylation	EPEDDIESPDYIEEP CCCCCCCCCCCCCCC	24.33	21183079
495	Phosphorylation	PGAEEVFTMPERKVK CCCCCEECCCCCCCC	36.67	-
497	Phosphorylation	AEEVFTMPERKVKPP CCCEECCCCCCCCCC	34.87	-
499	Phosphorylation	EVFTMPERKVKPPIA CEECCCCCCCCCCCC	43.10	24719451
517	Phosphorylation	PLARRPPSLVHRPPS CCCCCCCCCCCCCCC	45.78	29899451
524	Phosphorylation	SLVHRPPSLPGEYPL CCCCCCCCCCCCCCC	50.29	21183079
525	Phosphorylation	LVHRPPSLPGEYPLT CCCCCCCCCCCCCCC	8.56	-
529	Phosphorylation	PPSLPGEYPLTSPTM CCCCCCCCCCCCCHH	14.95	21183079
532	Phosphorylation	LPGEYPLTSPTMAMA CCCCCCCCCCHHHHH	28.31	26060331
533	Phosphorylation	PGEYPLTSPTMAMAS CCCCCCCCCHHHHHC	26.51	24719451
557	Phosphorylation	LPQDSYTVLRKPKSP CCCCCEEEECCCCCC	3.55	24719451
559	Phosphorylation	QDSYTVLRKPKSPSF CCCEEEECCCCCCCC	49.22	24719451
565	Phosphorylation	LRKPKSPSFPGESTA ECCCCCCCCCCCCCC	51.68	26026062
568	Phosphorylation	PKSPSFPGESTASSS CCCCCCCCCCCCCCE	39.20	-
573	Phosphorylation	FPGESTASSSLVLSP CCCCCCCCCEEEEEC	22.13	24719451
575	Phosphorylation	GESTASSSLVLSPLA CCCCCCCEEEEECCC	21.72	21183079
579	Phosphorylation	ASSSLVLSPLASSSG CCCEEEEECCCCCCC	15.47	25338131
592	Phosphorylation	SGAFFSGTQQPPQAS CCCCCCCCCCCCCCC	23.88	26026062
638	Phosphorylation	PPVPKKPSVLYLPLT CCCCCCCEEEEEECC	33.36	22802335
641	Phosphorylation	PKKPSVLYLPLTSPV CCCCEEEEEECCCCC	12.24	22802335
655	Phosphorylation	VAQMDACMAEPRLPF CHHHHHHHCCCCCCC	5.19	-
658	Phosphorylation	MDACMAEPRLPFSPI HHHHHCCCCCCCCCC	33.30	-
663	Phosphorylation	AEPRLPFSPIITLEE CCCCCCCCCCEEECC	17.16	27180971
666	Phosphorylation	RLPFSPIITLEEDGK CCCCCCCEEECCCCC	4.00	-
671	Phosphorylation	PIITLEEDGKCPSTG CCEEECCCCCCCCCC	53.10	-
676	Phosphorylation	EEDGKCPSTGDDQKS CCCCCCCCCCCCCCC	55.26	22802335
677	Phosphorylation	EDGKCPSTGDDQKSP CCCCCCCCCCCCCCC	29.76	22802335
681	Phosphorylation	CPSTGDDQKSPGKGV CCCCCCCCCCCCCCC	53.52	-
683	Phosphorylation	STGDDQKSPGKGVTS CCCCCCCCCCCCCCC	33.00	19060867
684	Phosphorylation	TGDDQKSPGKGVTSP CCCCCCCCCCCCCCC	56.39	-
685	Phosphorylation	GDDQKSPGKGVTSPL CCCCCCCCCCCCCCC	46.57	-
687	Phosphorylation	DQKSPGKGVTSPLHT CCCCCCCCCCCCCCC	33.57	-
689	Phosphorylation	KSPGKGVTSPLHTDT CCCCCCCCCCCCCCC	33.04	26745281
690	Phosphorylation	SPGKGVTSPLHTDTE CCCCCCCCCCCCCCC	24.06	25521595
694	Phosphorylation	GVTSPLHTDTEKEAI CCCCCCCCCCCCCCC	52.91	20415495
696	Phosphorylation	TSPLHTDTEKEAISP CCCCCCCCCCCCCCC	50.54	26804993
702	Phosphorylation	DTEKEAISPGRSVEP CCCCCCCCCCCCCCC	28.49	26804993
706	Phosphorylation	EAISPGRSVEPSAEE CCCCCCCCCCCCHHH	36.43	26060331
738	Phosphorylation	DVFVASRTTEDLFTV CEEEEECCHHHHHHH	31.85	29899451
739	Phosphorylation	VFVASRTTEDLFTVI EEEEECCHHHHHHHH	26.79	29899451
744	Phosphorylation	RTTEDLFTVIHRSKR CCHHHHHHHHHHHHC	26.33	29899451
749	Phosphorylation	LFTVIHRSKRKLLGW HHHHHHHHHCCCCCC	23.73	29899451
762	Acetylation	GWKETGEGFTGSKPS CCEECCCCCCCCCCC	27.10	-
765	Acetylation	ETGEGFTGSKPSSHS ECCCCCCCCCCCCCC	31.26	-
769	Phosphorylation	GFTGSKPSSHSPVKN CCCCCCCCCCCCCCC	44.40	26060331
770	Phosphorylation	FTGSKPSSHSPVKNT CCCCCCCCCCCCCCC	36.19	23684622
772	Phosphorylation	GSKPSSHSPVKNTAD CCCCCCCCCCCCCCC	33.08	26060331
780	Phosphorylation	PVKNTADSPTGEAAA CCCCCCCCCCCCCCC	23.15	19060867
782	Phosphorylation	KNTADSPTGEAAAAP CCCCCCCCCCCCCCC	52.16	25521595
800	Phosphorylation	SSACLDAGRNDDFKA CHHHHHCCCCHHHHH	28.70	24719451
813	Phosphorylation	KALLQKKGSKATPRT HHHHHHHCCCCCCCC	41.22	24719451
836	Phosphorylation	KTTNPLARRIIAQFS HHCCHHHHHHHHHHC	37.70	-
838	Phosphorylation	TNPLARRIIAQFSKD CCHHHHHHHHHHCCC	2.26	-
843	Phosphorylation	RRIIAQFSKDYEPTD HHHHHHHCCCCCCCC	16.73	27180971
846	Phosphorylation	IAQFSKDYEPTDNPS HHHHCCCCCCCCCCC	27.78	-
889	Phosphorylation	------------------------------------------ ------------------------------------------		24719451
894	Phosphorylation	----------------------------------------------- -----------------------------------------------		-
897	Phosphorylation	-------------------------------------------------- --------------------------------------------------		24719451
908	Phosphorylation	------------------------------------------------------------- -------------------------------------------------------------		24719451
1003	Phosphorylation	------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------		-
1006	Phosphorylation	--------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------		-
1010	Phosphorylation	------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------		24719451
1041	Phosphorylation	-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		-
1042	Phosphorylation	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		-
1048	Phosphorylation	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		21183079
1055	Phosphorylation	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		-
1147	Phosphorylation	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		24719451
1208	Phosphorylation	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NHSL2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NHSL2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NHSL2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NHSL2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.