| UniProt ID | SHAN3_MOUSE | |
|---|---|---|
| UniProt AC | Q4ACU6 | |
| Protein Name | SH3 and multiple ankyrin repeat domains protein 3 | |
| Gene Name | Shank3 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1730 | |
| Subcellular Localization | Cytoplasm. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendritic spine. In neuronal cells, extends into the region subjacent to the postsynaptic density (PSD). | |
| Protein Description | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.. | |
| Protein Sequence | MDGPGASAVVVRVGIPDLQQTKCLRLDPTAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQDYPPNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLRNGGAHLDFRTRDGLTAVHCATRQRNAGALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGTTDENGWQEIHQACRFGHVQHLEHLLFYGANMGAQNASGNTALHICALYNQESCARVLLFRGANKDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDVVPFRETPSYAKRRRLAGPSGLASPRPLQRSASDINLKGDQPAASPGPTLRSLPHQLLLQRLQEEKDRDRDGELENDISGPSAGRGGHNKISPSGPGGSGPAPGPGPASPAPPAPPPRGPKRKLYSAVPGRKFIAVKAHSPQGEGEIPLHRGEAVKVLSIGEGGFWEGTVKGRTGWFPADCVEEVQMRQYDTRHETREDRTKRLFRHYTVGSYDSLTSHSDYVIDDKVAILQKRDHEGFGFVLRGAKAETPIEEFTPTPAFPALQYLESVDVEGVAWRAGLRTGDFLIEVNGVNVVKVGHKQVVGLIRQGGNRLVMKVVSVTRKPEEDGARRRAPPPPKRAPSTTLTLRSKSMTAELEELASIRRRKGEKLDEILAVAAEPTLRPDIADADSRAATVKQRPTSRRITPAEISSLFERQGLPGPEKLPGSLRKGIPRTKSVGEDEKLASLLEGRFPRSTSMQDTVREGRGIPPPPQTAPPPPPAPYYFDSGPPPTFSPPPPPGRAYDTVRSSFKPGLEARLGAGAAGLYDPSTPLGPLPYPERQKRARSMIILQDSAPEVGDVPRPAPAATPPERPKRRPRPSGPDSPYANLGAFSASLFAPSKPQRRKSPLVKQLQVEDAQERAALAVGSPGPVGGSFAREPSPTHRGPRPGSLDYSSGEGLGLTFGGPSPGPVKERRLEERRRSTVFLSVGAIEGSPPSADLPSLQPSRSIDERLLGTGATTGRDLLLPSPVSALKPLVGGPSLGPSGSTFIHPLTGKPLDPSSPLALALAARERALASQTPSRSPTPVHSPDADRPGPLFVDVQTRDSERGPLASPAFSPRSPAWIPVPARREAEKPPREERKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPSRLGAEEERPGTPELAPAPMQAAAVAEPMPSPRAQPPGSIPADPGPGQGSSEEEPELVFAVNLPPAQLSSSDEETREELARIGLVPPPEEFANGILLTTPPPGPGPLPTTVPSPASGKPSSELPPAPESAADSGVEEADTRSSSDPHLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKPKLKSPLGKGPVTFRDPLLKQSSDSELMAQQHHAASTGLASAAGPARPRYLFQRRSKLWGDPVESRGLPGPEDDKPTVISELSSRLQQLNKDTRSLGEEPVGGLGSLLDPAKKSPIAAARLFSSLGELSTISAQRSPGGPGGGASYSVRPSGRYPVARRAPSPVKPASLERVEGLGAGVGGAGRPFGLTPPTILKSSSLSIPHEPKEVRFVVRSVSARSRSPSPSPLPSPSPGSGPSAGPRRPFQQKPLQLWSKFDVGDWLESIHLGEHRDRFEDHEIEGAHLPALTKEDFVELGVTRVGHRMNIERALRQLDGS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MDGPGASAVVVRVG -CCCCCCEEEEEECC | 6.56 | 21183079 | |
| 21 | Phosphorylation | GIPDLQQTKCLRLDP CCCCHHCCEEECCCC | 10.25 | 21183079 | |
| 24 (in isoform 10) | Phosphorylation | - | 17.00 | 29514104 | |
| 24 (in isoform 9) | Phosphorylation | - | 17.00 | 29514104 | |
| 74 (in isoform 10) | Phosphorylation | - | 35.67 | 23140645 | |
| 76 (in isoform 10) | Phosphorylation | - | 5.65 | 27180971 | |
| 78 (in isoform 10) | Phosphorylation | - | 17.41 | 22324799 | |
| 122 | Phosphorylation | NLKKFMDYVQLHSTD HHHHHHHHHHHCCHH | 4.09 | 22324799 | |
| 349 | Phosphorylation | DVVPFRETPSYAKRR CCCCCCCCCCHHHHC | 7.46 | 25521595 | |
| 351 | Phosphorylation | VPFRETPSYAKRRRL CCCCCCCCHHHHCHH | 4.70 | 29899451 | |
| 352 | Phosphorylation | PFRETPSYAKRRRLA CCCCCCCHHHHCHHC | 24.66 | 29472430 | |
| 362 | Phosphorylation | RRRLAGPSGLASPRP HCHHCCCCCCCCCCC | 2.35 | 24719451 | |
| 366 | Phosphorylation | AGPSGLASPRPLQRS CCCCCCCCCCCCCCC | 16.69 | 26370283 | |
| 371 (in isoform 6) | Phosphorylation | - | 44.11 | 19854140 | |
| 373 | Phosphorylation | SPRPLQRSASDINLK CCCCCCCCHHHCCCC | 2.49 | 27742792 | |
| 373 (in isoform 6) | Phosphorylation | - | 2.49 | 23737553 | |
| 375 | Phosphorylation | RPLQRSASDINLKGD CCCCCCHHHCCCCCC | 24.76 | 25521595 | |
| 376 (in isoform 6) | Phosphorylation | - | 2.64 | 25521595 | |
| 377 (in isoform 6) | Phosphorylation | - | 2.89 | 23737553 | |
| 380 (in isoform 6) | Phosphorylation | - | 43.19 | 23737553 | |
| 382 (in isoform 6) | Phosphorylation | - | 18.68 | 23737553 | |
| 387 | Phosphorylation | KGDQPAASPGPTLRS CCCCCCCCCCCCHHH | 50.47 | 25521595 | |
| 391 | Phosphorylation | PAASPGPTLRSLPHQ CCCCCCCCHHHHHHH | 20.67 | 22324799 | |
| 394 | Phosphorylation | SPGPTLRSLPHQLLL CCCCCHHHHHHHHHH | 5.80 | 25521595 | |
| 427 | Methylation | ISGPSAGRGGHNKIS CCCCCCCCCCCCCCC | 19.83 | 58859547 | |
| 434 | Phosphorylation | RGGHNKISPSGPGGS CCCCCCCCCCCCCCC | 26.49 | 29899451 | |
| 436 | Phosphorylation | GHNKISPSGPGGSGP CCCCCCCCCCCCCCC | 21.44 | 29899451 | |
| 441 | Phosphorylation | SPSGPGGSGPAPGPG CCCCCCCCCCCCCCC | 26.87 | 19854140 | |
| 450 | Phosphorylation | PAPGPGPASPAPPAP CCCCCCCCCCCCCCC | 40.03 | 17242355 | |
| 451 | Phosphorylation | APGPGPASPAPPAPP CCCCCCCCCCCCCCC | 33.25 | - | |
| 467 | Phosphorylation | RGPKRKLYSAVPGRK CCCCCCEEECCCCCE | 3.84 | - | |
| 482 | Phosphorylation | FIAVKAHSPQGEGEI EEEEEECCCCCCCCC | 47.50 | 25521595 | |
| 550 | Phosphorylation | TKRLFRHYTVGSYDS HHHHHHHCCCCCCCC | 4.11 | 29899451 | |
| 551 | Phosphorylation | KRLFRHYTVGSYDSL HHHHHHCCCCCCCCC | 4.90 | 29899451 | |
| 554 | Phosphorylation | FRHYTVGSYDSLTSH HHHCCCCCCCCCCCC | 31.21 | 21183079 | |
| 555 | Phosphorylation | RHYTVGSYDSLTSHS HHCCCCCCCCCCCCC | 11.20 | 21183079 | |
| 557 | Phosphorylation | YTVGSYDSLTSHSDY CCCCCCCCCCCCCCE | 24.63 | 25521595 | |
| 559 | Phosphorylation | VGSYDSLTSHSDYVI CCCCCCCCCCCCEEE | 66.63 | 29899451 | |
| 560 | Phosphorylation | GSYDSLTSHSDYVID CCCCCCCCCCCEEEC | 48.54 | 19060867 | |
| 562 | Phosphorylation | YDSLTSHSDYVIDDK CCCCCCCCCEEECCE | 44.98 | 21183079 | |
| 564 | Phosphorylation | SLTSHSDYVIDDKVA CCCCCCCEEECCEEE | 6.91 | 18034455 | |
| 619 (in isoform 2) | Phosphorylation | - | 48.26 | 23140645 | |
| 621 (in isoform 2) | Phosphorylation | - | 4.76 | 27180971 | |
| 623 (in isoform 2) | Phosphorylation | - | 26.88 | 22324799 | |
| 685 | Phosphorylation | PPPKRAPSTTLTLRS CCCCCCCCCEEEECC | 43.72 | 29472430 | |
| 686 | Phosphorylation | PPKRAPSTTLTLRSK CCCCCCCCEEEECCC | 22.48 | 22324799 | |
| 687 | Phosphorylation | PKRAPSTTLTLRSKS CCCCCCCEEEECCCC | 7.54 | 22324799 | |
| 689 | Phosphorylation | RAPSTTLTLRSKSMT CCCCCEEEECCCCCC | 6.90 | 22324799 | |
| 692 | Phosphorylation | STTLTLRSKSMTAEL CCEEEECCCCCCHHH | 2.67 | 25177544 | |
| 694 | Phosphorylation | TLTLRSKSMTAELEE EEEECCCCCCHHHHH | 6.56 | 25521595 | |
| 696 | Phosphorylation | TLRSKSMTAELEELA EECCCCCCHHHHHHH | 15.63 | 22324799 | |
| 698 (in isoform 2) | Phosphorylation | - | 4.29 | 19854140 | |
| 700 (in isoform 2) | Phosphorylation | - | 46.26 | 23737553 | |
| 703 (in isoform 2) | Phosphorylation | - | 8.61 | 25521595 | |
| 704 (in isoform 2) | Phosphorylation | - | 3.77 | 23737553 | |
| 707 (in isoform 2) | Phosphorylation | - | 6.31 | 23737553 | |
| 709 (in isoform 2) | Phosphorylation | - | 19.97 | 23737553 | |
| 771 | Phosphorylation | GPEKLPGSLRKGIPR CHHCCCCCCCCCCCC | 24.87 | 29472430 | |
| 779 | Phosphorylation | LRKGIPRTKSVGEDE CCCCCCCCCCCCCHH | 29.29 | 27742792 | |
| 781 | Phosphorylation | KGIPRTKSVGEDEKL CCCCCCCCCCCHHHH | 29.83 | 25521595 | |
| 790 | Phosphorylation | GEDEKLASLLEGRFP CCHHHHHHHHCCCCC | 50.79 | 19060867 | |
| 799 | Phosphorylation | LEGRFPRSTSMQDTV HCCCCCCCCCHHHHH | 27.23 | 27742792 | |
| 800 | Phosphorylation | EGRFPRSTSMQDTVR CCCCCCCCCHHHHHH | 12.53 | 25521595 | |
| 801 | Phosphorylation | GRFPRSTSMQDTVRE CCCCCCCCHHHHHHC | 29.35 | 27742792 | |
| 818 | Phosphorylation | GIPPPPQTAPPPPPA CCCCCCCCCCCCCCC | 32.03 | - | |
| 836 | Phosphorylation | FDSGPPPTFSPPPPP CCCCCCCCCCCCCCC | 39.81 | 29899451 | |
| 847 | Phosphorylation | PPPPGRAYDTVRSSF CCCCCCHHHHHHHHC | 8.98 | 29899451 | |
| 856 | Phosphorylation | TVRSSFKPGLEARLG HHHHHCCCCHHHHCC | 34.44 | 17242355 | |
| 890 | Phosphorylation | ERQKRARSMIILQDS HHHHHHHEEEEECCC | 28.42 | 19060867 | |
| 897 | Phosphorylation | SMIILQDSAPEVGDV EEEEECCCCCCCCCC | 46.58 | 19060867 | |
| 912 | Phosphorylation | PRPAPAATPPERPKR CCCCCCCCCCCCCCC | 14.75 | 19060867 | |
| 924 | Phosphorylation | PKRRPRPSGPDSPYA CCCCCCCCCCCCCCC | 12.73 | 21183079 | |
| 928 | Phosphorylation | PRPSGPDSPYANLGA CCCCCCCCCCCCCCH | 27.07 | 23737553 | |
| 930 | Phosphorylation | PSGPDSPYANLGAFS CCCCCCCCCCCCHHH | 39.87 | 23737553 | |
| 937 | Phosphorylation | YANLGAFSASLFAPS CCCCCHHHHHHCCCC | 7.70 | 20415495 | |
| 939 | Phosphorylation | NLGAFSASLFAPSKP CCCHHHHHHCCCCCC | 14.72 | 20415495 | |
| 944 | Phosphorylation | SASLFAPSKPQRRKS HHHHCCCCCCCCCCC | 3.62 | 20415495 | |
| 951 | Phosphorylation | SKPQRRKSPLVKQLQ CCCCCCCCCCHHHHC | 12.82 | 24719451 | |
| 965 | Asymmetric dimethylarginine | QVEDAQERAALAVGS CHHHHHHHHHHHCCC | 17.22 | - | |
| 965 | Methylation | QVEDAQERAALAVGS CHHHHHHHHHHHCCC | 17.22 | 24129315 | |
| 972 | Phosphorylation | RAALAVGSPGPVGGS HHHHHCCCCCCCCCC | 32.53 | 21183079 | |
| 979 | Phosphorylation | SPGPVGGSFAREPSP CCCCCCCCCCCCCCC | 3.40 | 21183079 | |
| 985 | Phosphorylation | GSFAREPSPTHRGPR CCCCCCCCCCCCCCC | 26.52 | 19060867 | |
| 987 | Phosphorylation | FAREPSPTHRGPRPG CCCCCCCCCCCCCCC | 41.29 | 21183079 | |
| 995 | Phosphorylation | HRGPRPGSLDYSSGE CCCCCCCCCCCCCCC | 37.39 | 25521595 | |
| 998 | Phosphorylation | PRPGSLDYSSGEGLG CCCCCCCCCCCCCCC | 46.44 | 21183079 | |
| 999 | Phosphorylation | RPGSLDYSSGEGLGL CCCCCCCCCCCCCCC | 65.32 | 19060867 | |
| 1000 | Phosphorylation | PGSLDYSSGEGLGLT CCCCCCCCCCCCCCC | 32.49 | 19060867 | |
| 1007 | Phosphorylation | SGEGLGLTFGGPSPG CCCCCCCCCCCCCCC | 32.91 | 29899451 | |
| 1012 | Phosphorylation | GLTFGGPSPGPVKER CCCCCCCCCCCHHHH | 19.20 | 22324799 | |
| 1027 | Phosphorylation | RLEERRRSTVFLSVG HHHHHHHCCEEEEEE | 44.18 | 19060867 | |
| 1028 | Phosphorylation | LEERRRSTVFLSVGA HHHHHHCCEEEEEEE | 10.97 | 19060867 | |
| 1032 | Phosphorylation | RRSTVFLSVGAIEGS HHCCEEEEEEECCCC | 5.23 | 19060867 | |
| 1039 | Phosphorylation | SVGAIEGSPPSADLP EEEECCCCCCCCCCC | 46.11 | 23649490 | |
| 1042 | Phosphorylation | AIEGSPPSADLPSLQ ECCCCCCCCCCCCCC | 11.41 | 21183079 | |
| 1047 | Phosphorylation | PPSADLPSLQPSRSI CCCCCCCCCCCCCCC | 21.78 | 29899451 | |
| 1051 | Phosphorylation | DLPSLQPSRSIDERL CCCCCCCCCCCCHHH | 19.67 | 29899451 | |
| 1053 | Phosphorylation | PSLQPSRSIDERLLG CCCCCCCCCCHHHCC | 21.59 | 29899451 | |
| 1061 | O-linked_Glycosylation | IDERLLGTGATTGRD CCHHHCCCCCCCCCC | 42.83 | 55413775 | |
| 1073 | Phosphorylation | GRDLLLPSPVSALKP CCCCCCCCCHHHCCC | 15.27 | 28978645 | |
| 1076 | Phosphorylation | LLLPSPVSALKPLVG CCCCCCHHHCCCCCC | 27.35 | 29472430 | |
| 1090 | Phosphorylation | GGPSLGPSGSTFIHP CCCCCCCCCCEEECC | 37.07 | - | |
| 1093 | Phosphorylation | SLGPSGSTFIHPLTG CCCCCCCEEECCCCC | 43.18 | - | |
| 1122 | Phosphorylation | ARERALASQTPSRSP HHHHHHHHCCCCCCC | 47.11 | 24719451 | |
| 1126 | Phosphorylation | ALASQTPSRSPTPVH HHHHCCCCCCCCCCC | 26.21 | 19060867 | |
| 1128 | Phosphorylation | ASQTPSRSPTPVHSP HHCCCCCCCCCCCCC | 38.43 | 27742792 | |
| 1130 | Phosphorylation | QTPSRSPTPVHSPDA CCCCCCCCCCCCCCC | 35.89 | 29899451 | |
| 1134 | Phosphorylation | RSPTPVHSPDADRPG CCCCCCCCCCCCCCC | 7.85 | 25521595 | |
| 1149 | Phosphorylation | PLFVDVQTRDSERGP CEEEEEECCCCCCCC | 23.34 | 27742792 | |
| 1152 | Phosphorylation | VDVQTRDSERGPLAS EEEECCCCCCCCCCC | 21.60 | 29899451 | |
| 1159 | Phosphorylation | SERGPLASPAFSPRS CCCCCCCCCCCCCCC | 10.92 | 21082442 | |
| 1163 | Phosphorylation | PLASPAFSPRSPAWI CCCCCCCCCCCCCCC | 20.75 | 29899451 | |
| 1166 | Phosphorylation | SPAFSPRSPAWIPVP CCCCCCCCCCCCCCC | 33.56 | 23737553 | |
| 1194 | Phosphorylation | KSPEDKKSMILSVLD CCHHHHHHHHHHHHH | 11.61 | 29472430 | |
| 1203 | Phosphorylation | ILSVLDTSLQRPAGL HHHHHHHCCCCCCEE | 37.15 | 21183079 | |
| 1234 | Phosphorylation | AEEERPGTPELAPAP CCCCCCCCCCCCCCC | 25.17 | 25521595 | |
| 1253 | Phosphorylation | AVAEPMPSPRAQPPG HHCCCCCCCCCCCCC | 28.44 | 21082442 | |
| 1293 | Phosphorylation | PPAQLSSSDEETREE CHHHCCCCCHHHHHH | 52.38 | 23649490 | |
| 1420 | Phosphorylation | PPKPKLKSPLGKGPV CCCCCCCCCCCCCCC | 7.13 | 29472430 | |
| 1437 | Phosphorylation | RDPLLKQSSDSELMA CCHHHHCCCCHHHHH | 39.23 | 19060867 | |
| 1438 | Phosphorylation | DPLLKQSSDSELMAQ CHHHHCCCCHHHHHH | 34.78 | 19060867 | |
| 1440 | Phosphorylation | LLKQSSDSELMAQQH HHHCCCCHHHHHHHH | 35.15 | 19060867 | |
| 1456 | Phosphorylation | AASTGLASAAGPARP HHHHHHHHHHCCCCC | 16.65 | 28059163 | |
| 1471 | Phosphorylation | RYLFQRRSKLWGDPV HHHHHCCHHHHCCCC | 23.48 | 19060867 | |
| 1508 | Phosphorylation | LQQLNKDTRSLGEEP HHHHCHHHHHCCCCC | 12.51 | 29899451 | |
| 1510 | Phosphorylation | QLNKDTRSLGEEPVG HHCHHHHHCCCCCCC | 56.68 | 25521595 | |
| 1521 | Phosphorylation | EPVGGLGSLLDPAKK CCCCCHHHHCCHHHC | 22.31 | 19060867 | |
| 1529 | Phosphorylation | LLDPAKKSPIAAARL HCCHHHCCHHHHHHH | 3.26 | 19060867 | |
| 1538 | Phosphorylation | IAAARLFSSLGELST HHHHHHHHHHHHHHE | 31.23 | 29899451 | |
| 1539 | Phosphorylation | AAARLFSSLGELSTI HHHHHHHHHHHHHEE | 34.92 | 23737553 | |
| 1544 | Phosphorylation | FSSLGELSTISAQRS HHHHHHHHEEEEECC | 37.19 | 23737553 | |
| 1545 | Phosphorylation | SSLGELSTISAQRSP HHHHHHHEEEEECCC | 27.62 | 29472430 | |
| 1551 | Phosphorylation | STISAQRSPGGPGGG HEEEEECCCCCCCCC | 32.27 | 26370283 | |
| 1577 | Phosphorylation | PVARRAPSPVKPASL CCCCCCCCCCCCCCH | 44.60 | 25195567 | |
| 1583 | Phosphorylation | PSPVKPASLERVEGL CCCCCCCCHHHCCCC | 24.62 | 19060867 | |
| 1611 | Phosphorylation | TPPTILKSSSLSIPH CCCCCEECCCCCCCC | 4.13 | 29899451 | |
| 1612 | Phosphorylation | PPTILKSSSLSIPHE CCCCEECCCCCCCCC | 3.77 | 29472430 | |
| 1613 | Phosphorylation | PTILKSSSLSIPHEP CCCEECCCCCCCCCC | 29.28 | 29472430 | |
| 1615 | Phosphorylation | ILKSSSLSIPHEPKE CEECCCCCCCCCCCE | 6.31 | 29472430 | |
| 1629 | Phosphorylation | EVRFVVRSVSARSRS EEEEEEEEEECCCCC | 22.51 | 29899451 | |
| 1631 | Phosphorylation | RFVVRSVSARSRSPS EEEEEEEECCCCCCC | 50.90 | 29899451 | |
| 1634 | Phosphorylation | VRSVSARSRSPSPSP EEEEECCCCCCCCCC | 14.47 | 21082442 | |
| 1636 | Phosphorylation | SVSARSRSPSPSPLP EEECCCCCCCCCCCC | 15.62 | 25521595 | |
| 1638 | Phosphorylation | SARSRSPSPSPLPSP ECCCCCCCCCCCCCC | 8.73 | 25521595 | |
| 1640 | Phosphorylation | RSRSPSPSPLPSPSP CCCCCCCCCCCCCCC | 38.69 | 29899451 | |
| 1644 | Phosphorylation | PSPSPLPSPSPGSGP CCCCCCCCCCCCCCC | 12.94 | 23984901 | |
| 1646 | Phosphorylation | PSPLPSPSPGSGPSA CCCCCCCCCCCCCCC | 4.85 | 29472430 | |
| 1649 | Phosphorylation | LPSPSPGSGPSAGPR CCCCCCCCCCCCCCC | 40.90 | 21183079 | |
| 1652 | Phosphorylation | PSPGSGPSAGPRRPF CCCCCCCCCCCCCCC | 41.14 | 21183079 | |
| 1709 | Phosphorylation | TKEDFVELGVTRVGH CHHHHHHHCCCCHHH | 36.51 | 17242355 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SHAN3_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SHAN3_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SHAN3_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-469, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-450; SER-856 ANDSER-1709, AND MASS SPECTROMETRY. | |
| "Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain."; Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.; J. Proteome Res. 7:311-318(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-197; TYR-630 ANDTYR-639, AND MASS SPECTROMETRY. | |
