PP1R7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PP1R7_MOUSE
• UniProt AC: Q3UM45
• Protein Name: Protein phosphatase 1 regulatory subunit 7
• Gene Name: Ppp1r7
• Organism: Mus musculus (Mouse).
• Sequence Length: 361
• Subcellular Localization: Nucleus.
• Protein Description: Regulatory subunit of protein phosphatase 1..
• Protein Sequence: MAAERGAGQQQSQEMMEVDRRVESEESGDEEGKKHGGGGIVANLSEQSLKDGVDRGAEDPEEEHELAVDMETINLDRDAEDVDLTHYRIGKIEGLEVLKKVKSLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEVLDISFNMLRNIEGIDKLTQLKKLFLVNNKINKIENISNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSVQSNRLAKIEGLQSLVNLRELYLSNNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQIDATYVRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAERGAGQ ------CCCCCCCCH	20.31	-
12	Phosphorylation	RGAGQQQSQEMMEVD CCCCHHHHHHHHHHH	24.62	25521595
23	Ubiquitination	MEVDRRVESEESGDE HHHHHHHHHCHHCCC	51.09	27667366
24	Phosphorylation	EVDRRVESEESGDEE HHHHHHHHCHHCCCC	43.75	27087446
27	Phosphorylation	RRVESEESGDEEGKK HHHHHCHHCCCCCCC	47.71	27087446
45	Phosphorylation	GGIVANLSEQSLKDG CCHHCCCCHHHHHCC	33.14	25521595
48	Phosphorylation	VANLSEQSLKDGVDR HCCCCHHHHHCCCCC	33.08	25521595
134	Acetylation	DLYDNQIKKIENLEA CCCHHHHHHHHCHHH	37.62	23236377
134	Malonylation	DLYDNQIKKIENLEA CCCHHHHHHHHCHHH	37.62	26320211
163	Ubiquitination	RNIEGIDKLTQLKKL CCCCCHHHHHHHHHH	52.06	22790023
169	Ubiquitination	DKLTQLKKLFLVNNK HHHHHHHHHHHHCCC	53.73	22790023
176	Ubiquitination	KLFLVNNKINKIENI HHHHHCCCCCHHHHC	42.31	22790023
183	Ubiquitination	KINKIENISNLHQLQ CCCHHHHCCCHHHHH	1.55	27667366
184	Phosphorylation	INKIENISNLHQLQM CCHHHHCCCHHHHHH	44.94	28464351
190	Ubiquitination	ISNLHQLQMLELGSN CCCHHHHHHHHHCCC	28.04	27667366
218	Ubiquitination	LESLFLGKNKITKLQ HHHHHCCCCCCHHHC	58.16	22790023
231	Phosphorylation	LQNLDALTNLTVLSV HCCHHHHHCCEEEEC	29.87	-
323	Phosphorylation	DELKGARSLETVYLE HHHCCCCCCCEEEEC	29.98	27742792
326	Phosphorylation	KGARSLETVYLERNP CCCCCCCEEEECCCC	21.53	26643407
328	Phosphorylation	ARSLETVYLERNPLQ CCCCCEEEECCCCCC	15.40	26643407
336	Malonylation	LERNPLQKDPQYRRK ECCCCCCCCHHHHHH	78.16	30639696
336	Ubiquitination	LERNPLQKDPQYRRK ECCCCCCCCHHHHHH	78.16	27667366
343	Ubiquitination	KDPQYRRKVMLALPS CCHHHHHHHHHHCCC	24.01	27667366
350	Phosphorylation	KVMLALPSVRQIDAT HHHHHCCCCEECCCE	30.68	21454597
357	Phosphorylation	SVRQIDATYVRF--- CCEECCCEEECC---	20.85	21454597
358	Phosphorylation	VRQIDATYVRF---- CEECCCEEECC----	7.43	21454597

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PP1R7_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PP1R7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PP1R7_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PP1A_HUMAN	PPP1CA	physical	26496610
PP1B_HUMAN	PPP1CB	physical	26496610
PP1G_HUMAN	PPP1CC	physical	26496610
PP1RB_HUMAN	PPP1R11	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24 AND SER-27, AND MASSSPECTROMETRY.
PubMed: 19367708