SPD2B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPD2B_MOUSE
• UniProt AC: A2AAY5
• Protein Name: SH3 and PX domain-containing protein 2B
• Gene Name: Sh3pxd2b
• Organism: Mus musculus (Mouse).
• Sequence Length: 908
• Subcellular Localization: Cytoplasm. Cell projection, podosome. Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.
• Protein Description: Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation..
• Protein Sequence: MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGATEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGNDPTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVVQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKLGPSSPAHSGALDLDGVSRHQNAMGREKELLNNQRDGRFEGRLVPDGDVKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPHEMTQLRLGDAAATENNTGPEAVGPSRPLPEAPHGAVDSGMLWSKDWKGGKEAPRKASSDLSASTGYEEISDPTQEEKPSLPPRKESIIKSEEELLERERQKMEPLRGSSPKPPGMILPMIPAKHAPLARDSRKPEPKLDKSKFPLRNDMGLECGHKVLAKEVKKPNLRPISRSKAELSEEKVDPTSQNLFMKSRPQVRPKPTPSPKTEPAQSEDHVDIYNLRSKLRPAKSQEKALLDGESHHAAGSHDTALSRSFLPGEGPGHGQDRSGRQDGLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEATLQQRPVVPPRRPPPPKKTSSSPLSCRPLPEVRGAQREESRVAPAAGRALLVPPKAKPFLSNSSVGQDDMRGKGGLGPRVTGKVGETREKAASFLNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	RRVPNKHYVYIIRVT CCCCCCEEEEEEEEE	9.14	19144821
42	Phosphorylation	SGATEAIYRRYSKFF CCHHHHHHHHHHHHH	8.97	22817900
85	Phosphorylation	GKILFRRSHIRDVAV CCEEEECHHHHHHHH	21.00	20531401
226	Phosphorylation	QPEEEEKYTVIYPYT CCCCHHCEEEEEEEC	14.98	29514104
230	Phosphorylation	EEKYTVIYPYTARDQ HHCEEEEEEECCCCC	5.95	-
279	Phosphorylation	ASYLKKNSGEPLPPK HHHCCCCCCCCCCCC	54.11	-
290	Phosphorylation	LPPKLGPSSPAHSGA CCCCCCCCCCCCCCC	47.35	22942356
291	Phosphorylation	PPKLGPSSPAHSGAL CCCCCCCCCCCCCCC	29.28	27087446
295	Phosphorylation	GPSSPAHSGALDLDG CCCCCCCCCCCCCCH	28.06	22942356
304	Phosphorylation	ALDLDGVSRHQNAMG CCCCCHHHHHHHCHH	29.58	25777480
339	Phosphorylation	DGDVKQRSPKMRQRP CCCHHHCCCCHHCCC	26.78	24453211
353	Phosphorylation	PPPRRDMTIPRGLNL CCCCCCCCCCCCCCC	31.92	-
429	Phosphorylation	IDKYKKTSSASRPNF HHHHHCCCCCCCCCC	32.55	24719451
499	Phosphorylation	KEAPRKASSDLSAST CCCCCCHHCCCCHHC	27.67	27742792
500	Phosphorylation	EAPRKASSDLSASTG CCCCCHHCCCCHHCC	47.64	27742792
503	Phosphorylation	RKASSDLSASTGYEE CCHHCCCCHHCCCCC	25.76	25619855
505	Phosphorylation	ASSDLSASTGYEEIS HHCCCCHHCCCCCCC	20.99	25619855
506	Phosphorylation	SSDLSASTGYEEISD HCCCCHHCCCCCCCC	43.42	25619855
508	Phosphorylation	DLSASTGYEEISDPT CCCHHCCCCCCCCCC	15.52	25619855
512	Phosphorylation	STGYEEISDPTQEEK HCCCCCCCCCCCCCC	40.60	25619855
515	Phosphorylation	YEEISDPTQEEKPSL CCCCCCCCCCCCCCC	54.31	25619855
521	Phosphorylation	PTQEEKPSLPPRKES CCCCCCCCCCCCHHH	65.65	25619855
528	Phosphorylation	SLPPRKESIIKSEEE CCCCCHHHHHCCHHH	32.42	26824392
532	Phosphorylation	RKESIIKSEEELLER CHHHHHCCHHHHHHH	39.57	25619855
550	Phosphorylation	KMEPLRGSSPKPPGM HCCCCCCCCCCCCCC	36.71	26160508
551	Phosphorylation	MEPLRGSSPKPPGMI CCCCCCCCCCCCCCE	39.50	26824392
573	Phosphorylation	HAPLARDSRKPEPKL CCCCCCCCCCCCCCC	36.33	24719451
598	Acetylation	MGLECGHKVLAKEVK CCCCCCHHHHHHHHC	24.99	22826441
613	Phosphorylation	KPNLRPISRSKAELS CCCCCCCCCCHHHHC	32.93	29176673
620	Phosphorylation	SRSKAELSEEKVDPT CCCHHHHCCCCCCCH	34.90	23737553
661	Phosphorylation	SEDHVDIYNLRSKLR CCCCEEHHHHHHHHC	12.04	25338131
672	Phosphorylation	SKLRPAKSQEKALLD HHHCCCHHHHHHHHC	45.75	25159016
682	Phosphorylation	KALLDGESHHAAGSH HHHHCCCCCCCCCCC	26.54	29514104
688	Phosphorylation	ESHHAAGSHDTALSR CCCCCCCCCCCCCCC	17.29	25338131
717	Phosphorylation	SGRQDGLSPKETPCR CCCCCCCCCCCCCCC	39.18	21743459
723	Glutathionylation	LSPKETPCRAPPRPA CCCCCCCCCCCCCCC	8.27	24333276
766	Phosphorylation	RPPPPKKTSSSPLSC CCCCCCCCCCCCCCC	39.71	23984901
767	Phosphorylation	PPPPKKTSSSPLSCR CCCCCCCCCCCCCCC	37.38	23984901
768	Phosphorylation	PPPKKTSSSPLSCRP CCCCCCCCCCCCCCC	41.00	24453211
769	Phosphorylation	PPKKTSSSPLSCRPL CCCCCCCCCCCCCCC	29.63	24453211
772	Phosphorylation	KTSSSPLSCRPLPEV CCCCCCCCCCCCCHH	16.09	24453211
840	Phosphorylation	ETREKAASFLNADGP CCHHHHHHHHCCCCC	34.82	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPD2B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPD2B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPD2B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SPD2B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-528; SER-672 ANDSER-840, AND MASS SPECTROMETRY.
PubMed: 19144319